Ramy Sedhom, MD

faculty photo
Clinical Assistant Professor of Medicine (Hematology-Oncology)
Collaborator , Penn Medicine Princeton Health
Associate Director, PC3I & Director, Program in Geriatric Oncology & Supportive Care Innovation, PC3I, Penn Center for Cancer Care Innovation/University of Pennsylvania
Co-Lead Geriatric Oncology Core, Penn Cancer Service Line
Division Chief Palliative Care, Penn Medicine Princeton Medical Center
Senior Fellow, Leonard Davis Institute of Health Economics
Director of Cancer Research, Penn Medicine Princeton Health
Founder, Director, Psychosocial Oncology Program, Penn Medicine Princeton Health
Co-Director, Center for Cancer and Aging (newly founded under Dr. Vonderheide and PC3I)
Division Chief of Medical Oncology , Penn Medicine Princeton Health
Department: Medicine

Contact information
Penn Medicine Princeton Health
1 Plainsboro Road
Plainsboro, NJ 08536
Education:
BA (Religious Studies, Biology)
Siena College, 2010.
MD (Medicine)
Albany Medical School, 2014.
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Description of Clinical Expertise

Dr. Ramy Sedhom, MD, is a highly regarded oncologist with deep clinical expertise in managing complex cancer cases, particularly through the integration of palliative care into oncology. His practice focuses on providing individualized cancer treatment while prioritizing the quality of life for his patients. With a particular interest in geriatric oncology, Dr. Sedhom tailors therapies for older adults, understanding the unique challenges faced by elderly patients undergoing cancer treatment. He is adept at balancing the latest advancements in cancer therapeutics with the nuanced needs of vulnerable populations, ensuring that each patient receives compassionate, evidence-based care.

In addition to his clinical acumen in oncology, Dr. Sedhom is a leading advocate for early palliative care interventions, emphasizing symptom management, patient well-being, and holistic support throughout the cancer care continuum. He has extensive experience in managing a range of malignancies, and his disease specific expertise includes breast, gynecologic and genitourinary cancers. Dr. Sedhom’s patient-centered approach extends to his leadership in multidisciplinary teams, where he collaborates with specialists to optimize outcomes and create comprehensive care plans that integrate both curative and supportive therapies.

Description of Research Expertise

Dr. Ramy Sedhom, MD, serves as the Medical Director of Oncology and Palliative Care at Penn Medicine Princeton Health and is an Assistant Professor of Clinical Medicine at the University of Pennsylvania. Dr. Sedhom is a recognized leader in oncology, specializing in the integration of palliative care with cancer treatment, ensuring patients receive comprehensive care that addresses both their medical and quality-of-life needs. His expertise extends across cancer center leadership, complex decision-making in cancer care, and enhancing patient experiences through personalized treatment plans. He is also a passionate advocate for geriatric oncology, leading efforts to tailor cancer therapies for elderly and vulnerable populations.

Dr. Sedhom is a sought-after speaker on various oncology topics, including the implementation of palliative care models in clinical practice, advancements in cancer therapeutics, and strategies for improving patient outcomes through holistic care. His content areas of focus include palliative and supportive care, the intersection of oncology with geriatrics, multidisciplinary cancer management, and the future of cancer care delivery in academic and community settings. His work reflects a commitment to patient-centered care and the ongoing evolution of oncology practices to meet diverse patient needs.

Selected Publications

Aleixo G, Voruganti T, Sedhom R.: "The Fox and the Grapes" to inform precision oncology in the older adult. J Geriatr Oncol. 2025.

Aleixo G, Patel T, Ani J, Ferrell WJ, Dotan E, Takvorian SU, Williams GR, Parikh RB, Sedhom R: "Start low, go slow," a strategy to tailor treatment dosing in older or vulnerable adults with advanced solid cancer: A systematic review and meta-analysis. J Geriatr Oncol 2025.

Parikh RB, Ferrell WJ, Li Y, Chen J, Bilbrey L, Johnson N, White J, Sedhom R, Dickson NR, Schleicher S, Bekelman JE, Mudumbi S: Algorithm-Based Palliative Care in Patients With Cancer: A Cluster Randomized Clinical Trial. JAMA Netw Open. 2025.

Balanchivadze N, Blackford AL, Sedhom R, Broman KK, Gupta A, Hussaini SMQ.: Geographic Disparities in Head and Neck Cancer Mortality and Place of Death. JAMA Otolaryngol Head Neck Surg 150: 743-746, Aug 2024.

Sedhom R, Smith TJ, Cassel JB, Isenberg SR.: What Is the Value of Palliative Care for Inpatients With Cancer? JCO Oncol Pract Jul 2024.

Aleixo G, Lavelle MP, Sedhom R.: Anthracyclines in Older Adults With Hodgkin Lymphoma: Too Much, Too Little? Getting it Just Right. JACC CardioOncol 6: 214-216, Apr 2024.

Aleixo G, Patel T, Ani J, Ferrell WJ, Dotan E, Takvorian SU, Williams GR, Parikh RB, Sedhom R: "Start low, go slow," a strategy to tailor treatment dosing in older or vulnerable adults with advanced solid cancer: A systematic review and meta-analysis. J Geriatr Oncol. 2024.

Ramy Sedhom: New ASCO Series for Early-Career Cancer Providers on Impacts of Social Determinants of Health ASCO Blog 2024.

Sedhom R, Bates-Pappas GE, Feldman J, Elk R, Gupta A, Fisch MJ, Soto-Perez-de-Celis E.: Tumor Is Not the Only Target: Ensuring Equitable Person-Centered Supportive Care in the Era of Precision Medicine. Am Soc Clin Oncol Educ Book 2024.

Alicia Ault: ‘Nonsensical’ Limits on Supportive Drugs Complicate Cancer Care. MEDSCAPE 2024.

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Last updated: 03/14/2025
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