Megan Jennings, MD, PhD
Clinical Assistant Professor of Pediatrics (General Pediatrics)
Attending Physician, Division of General Pediatrics, Section of Pediatric Hospital Medicine, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of General Pediatrics
Section of Pediatric Hospital Medicine
3500 Civic Center Blvd.
Philadelphia, PA 19104
Division of General Pediatrics
Section of Pediatric Hospital Medicine
3500 Civic Center Blvd.
Philadelphia, PA 19104
Education:
BS (Chemistry with Teaching)
Temple University, 2012.
PhD (Bio-Organic Chemistry)
Temple University, 2017.
MD (Medicine)
Temple University School of Medicine, 2021.
Permanent linkBS (Chemistry with Teaching)
Temple University, 2012.
PhD (Bio-Organic Chemistry)
Temple University, 2017.
MD (Medicine)
Temple University School of Medicine, 2021.
Description of Research Expertise
Bioorganic chemistryQuaternary ammonium compounds
Biofilm
Structure-activity relationship
Selected Publications
Alkhalifa S, Jennings MC, Granata D, Klein M, Wuest WM, Minbiole KPC, Carnevale V.: Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study. Chembiochem 21(1): 1510-1516, May 2020.Le P, Kunold E, Macsics R, Rox K, Jennings MC, Ugur I, Reinecke M, Chaves-Moreno D, Hackl MW, Fetzer C, Mandl FAM, Lehmann J, Korotkov VS, Hacker SM, Kuster B, Antes I, Pieper DH, Rohde M, Wuest WM, Medina E, Sieber SA: Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms. Nat. Chem 12(4): 145-158, Mar 2020.
Hofbauer B, Vomacka J, Stahl M, Korotkov VS, Jennings MC, Wuest WM, Sieber SA: Dual Inhibitor of Staphylococcus aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins. Biochemistry 57(1): 1814-1820, Mar 2018.
Jennings MC, Forman ME, Duggan SM, Minbiole KPC, Wuest WM: Efflux Pumps Might Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus. Chembiochem 18(4): 1573-1577, Aug 2017.
Allen RA, Jennings MC, Mitchell MA, Al-Khalifa SE, Wuest WM, Minbiole KPC: Ester- and amide-containing multiQACs: Exploring multicationic soft antimicrobial agents. Bioorg Med Chem Lett 27(8): 2107-2112, May 2017.
Al-Khalifa SE, Jennings MC, Wuest WM, Minbiole KP: The Development of Next-Generation Pyridinium-Based multiQAC Antiseptics. ChemMedChem 12(5): 280-283, Feb 2017.
Forman ME, Jennings MC, Wuest WM, Minbiole KP: Building a Better Quaternary Ammonium Compound (QAC): Branched Tetracationic Antiseptic Amphiphiles. ChemMedChem 11(5): 1401-5, Jul 2016.
Forman ME, Fletcher MH, Jennings MC, Duggan SM, Minbiole KP, Wuest WM.: Structure-Resistance Relationships: Interrogating Antiseptic Resistance in Bacteria with Multicationic Quaternary Ammonium Dyes. ChemMedChem 11(6): 958-62, May 2016.
Joyce MD, Jennings MC, Santiago CN, Fletcher MH, Wuest WM, Minbiole KP: Natural product-derived quaternary ammonium compounds with potent antimicrobial activity. J Antibiot (Tokyo) 69(4): 344-7, April 2016.
Jennings MC, Wuest WM: Natural Product-Inspired Approaches to Combat Bacteria. Tetrahedron 72(1): 3547, April 2016.