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Jared Benjamin Parker, PhD
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Adjunct Assistant Professor of Medicine (Infectious Diseases)
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Sr. Research Investigator, University of Pennsylvania, Philadelphia, PA
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Department: Medicine
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Contact information
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3610 Hamilton Walk
3c Johnson Pavilion, Lab 503
Philadelphia, PA 19104
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3c Johnson Pavilion, Lab 503
Philadelphia, PA 19104
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Publications
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Links
a3 Search PubMed for articles
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a3 Search PubMed for articles
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Education:
21 9 B.S. 16 (Chemistry) c
4c University of Alabama at Birmingham, Birmingham, AL, 2004.
21 8 PhD 21 (Molecular Biophysics) c
53 Johns Hopkins University School of Medicine, Baltimore, MD, 2010.
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Permanent link21 9 B.S. 16 (Chemistry) c
4c University of Alabama at Birmingham, Birmingham, AL, 2004.
21 8 PhD 21 (Molecular Biophysics) c
53 Johns Hopkins University School of Medicine, Baltimore, MD, 2010.
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1b Protein Engineering
12 DNA Repair
16 Genomic Editing
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Description of Clinical Expertise
35 In Vitro Diagnostic Assay Development71
Description of Research Expertise
2b Protein & DNA Biochemistry1b Protein Engineering
12 DNA Repair
16 Genomic Editing
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f2 Parker JB, Walsh CT.: Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin. Biochemistry 52(5): 889-901, Feb 2013.
114 Parker JB, Walsh CT.: Stereochemical outcome at four stereogenic centers during conversion of prephenate to tetrahydrotyrosine by BacABGF in the bacilysin pathway. Biochemistry 51(28): 5622-32, Jul 2012.
fb Parker JB, Walsh CT.: Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis. Biochemistry 51(15): 3241-51, Apr 2012.
b3 Parker JB, Stivers JT.: Dynamics of uracil and 5-fluorouracil in DNA. Biochemistry 50(5): 612-7, Feb 2011.
13b Grogan BC, Parker JB, Guminski AF, Stivers JT.: Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA. Biochemistry 50(5): 618-27, Feb 2011.
fc Chung S, Parker JB, Bianchet M, Amzel LM, Stivers JT.: Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nat Chem Biol 5(6): 407-413, June 2009.
e1 Parker JB, Stivers JT.: Uracil DNA glycosylase: revisiting substrate-assisted catalysis by DNA phosphate anions. Biochemistry 47(33): 8614-22, Aug 2008.
100 Parker JB, Bianchet MA, Krosky DJ, Friedman JI, Amzel LM, Stivers JT.: Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature 449(7161): 433-7, Sep 2007.
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Selected Publications
159 Zhang Z, Baxter AE, Ren D, Qin K, Chen Z, Collins SM, Huang H, Komar CA, Bailer PF, Parker JB, Blobel GA, Kohli RM, Wherry EJ, Berger SL, Shi J.: Efficient engineering of human and mouse primary cells using peptide-assisted genome editing. Nature Biotechnology April 2023.f2 Parker JB, Walsh CT.: Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin. Biochemistry 52(5): 889-901, Feb 2013.
114 Parker JB, Walsh CT.: Stereochemical outcome at four stereogenic centers during conversion of prephenate to tetrahydrotyrosine by BacABGF in the bacilysin pathway. Biochemistry 51(28): 5622-32, Jul 2012.
fb Parker JB, Walsh CT.: Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis. Biochemistry 51(15): 3241-51, Apr 2012.
b3 Parker JB, Stivers JT.: Dynamics of uracil and 5-fluorouracil in DNA. Biochemistry 50(5): 612-7, Feb 2011.
13b Grogan BC, Parker JB, Guminski AF, Stivers JT.: Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA. Biochemistry 50(5): 618-27, Feb 2011.
fc Chung S, Parker JB, Bianchet M, Amzel LM, Stivers JT.: Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nat Chem Biol 5(6): 407-413, June 2009.
e1 Parker JB, Stivers JT.: Uracil DNA glycosylase: revisiting substrate-assisted catalysis by DNA phosphate anions. Biochemistry 47(33): 8614-22, Aug 2008.
100 Parker JB, Bianchet MA, Krosky DJ, Friedman JI, Amzel LM, Stivers JT.: Enzymatic capture of an extrahelical thymine in the search for uracil in DNA. Nature 449(7161): 433-7, Sep 2007.
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