Eleanna Kaffe, PhD
Instructor A of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
422 Curie Boulevard
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 4458956792
Lab: 215-573-4765
Lab: 215-573-4765
Publications
Education:
PhD
Medical School, University of Thessaly, , 2011.
Permanent linkPhD
Medical School, University of Thessaly, , 2011.
Description of Clinical Expertise
Clinical studies in patients with liver diseasesDescription of Other Expertise
Lung pathophysiology, pharmakodynamics, pharmacokinetics, liver cancerDescription of Research Expertise
Lipid metabolism, liver pathophysiology, mass spectometry, lipidomic analysis, liver humanization, liver fibrosisSelected Publications
Stylianaki EA, Magkrioti C, Kaffe E, Matralis AN, Aidinis V.: Amplex red assay, a standardized in vitro protocol to quantify the efficacy of autotaxin inhibitors. STAR Protoc. Jun 2025.York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA.: IL-10 constrains sphingolipid metabolism to limit inflammation. Nature Mar 2024.
Kaffe E, Tisi A, Magkrioti C, Aidinis V, Mehal WZ, Flavell RA, Maccarrone M.: Bioactive signalling lipids as drivers of chronic liver diseases. J Hepatol Jan 2024.
Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner DF, Mehal WZ; AlcHepNet; Yuval Kluger, Flavell RA.: Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell Aug 2023.
Ding C, Yu Z, Sefik E, Zhou J, Kaffe E, Wang G, Li B, Flavell RA, Hu W, Ye Y, Li HB.: A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver. Nat Aging. Jul 2023.
Magkrioti C, Kaffe E, Aidinis V.: The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer. Int J Mol Sci. May 2023.
Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, Sabihi M, Huber FJ, Reeh M, Grass JK, Wahib R, Seese H, Stüben BO, Fard-Aghaie M, Duprée A, Scognamiglio P, Plitzko G, Meiners J, Soukou S, Wittek A, Manthey C, Maroulis IC, Arck PC, Perez D, Gao B, Zarogiannis SG, Strowig T, Pasqualini R, Arap W, Gosálvez JS, Kobold S, Prinz I, Guse AH, Tachezy M, Ghadban T, Heumann A, Li J, Melling N, Mann O, Izbicki JR, Pantel K, Schumacher U, Lohse AW, Flavell RA, Gagliani N, Huber S.: Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22. Immunity Jan 2023.
Fabris L, Milani C, Fiorotto R, Mariotti V, Kaffe E, Seller B, Sonzogni A, Strazzabosco M, Cadamuro M: Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1-/- mouse model of congenital hepatic fibrosis. FASEB J. Jun 2022.
Sefik E, Israelow B, Mirza H, Zhao J, Qu R, Kaffe E, Song E, Halene S, Meffre E, Kluger Y, Nussenzweig M, Wilen CB, Iwasaki A, Flavell RA.: A humanized mouse model of chronic COVID-19. Nat Biotechnol Jun 2022.
Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA.: Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature Jun 2022.