Christina Osborne, MD, MSCS
Assistant Professor of Anesthesiology and Critical Care at the Children's Hospital of Philadelphia
Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care
Contact information
Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 2155901858
Email:
osbornec1@chop.edu
osbornec1@chop.edu
Education:
BA (Chemistry, English)
University of San Diego , 2007.
MD (Medicine)
University of Colorado, 2014.
MS (Clinical Science)
University of Colorado, 2022.
Permanent linkBA (Chemistry, English)
University of San Diego , 2007.
MD (Medicine)
University of Colorado, 2014.
MS (Clinical Science)
University of Colorado, 2022.
Description of Clinical Expertise
Pediatric Critical Care MedicinePediatric Infectious Diseases
Description of Research Expertise
Diagnostics of lower respiratory tract infections in childrenSelected Publications
Del Valle Ortiz D, Gunn-Sandell L, Deosthale-Bapat P, Lydon E, Ambroggio L, Wagner BD, Yehya N, Maddux AB, Leroue MK, Simões EAF, Langelier CR, Dominguez SR, Mourani PM, Osborne CM: Comparison of multiplex RT-PCR and RNA-Seq for detection of pathogens in tracheal aspirate samples in critically ill children. Pediatric Academic Societies April 2025 Notes: Poster presented at PAS 2025, Honolulu, HI.Osborne CM, Ambroggio L, Langelier C, Silviera L, Wagner BD, Yehya N, Levy R, Carpenter TC, Simões EAF, Maddux AB, Leroue MK, Tsitsiklas A, Mick E, Williamson K, Mourani PM, Dominguez SR: Multiplex Polymerase Chain Reaction Versus Standard Bacterial Culture in Critically Ill Children With Suspected Pneumonia. Pediatric Infectious Disease Journal 44(3): 263-269, March 2025.
Osborne CM, Ambroggio L, Langelier C, Silviera L, Wagner BD, Yehya N, Levy R, Carpenter TC, Simoes EAF, Maddux AB, Leroue MK, Tsitsiklas A, Mick E, Williamson K, Mourani PM, Dominguez SR: Multiplex Polymerase Chain Reaction Versus Standard Bacterial Culture in Critically Ill Children With Suspected Pneumonia. Pediatric Infectious Diseases Journal 44(3): 263-269, March 2025.
Lydon E, Osborne CM, Wagner BD, Ambroggio L, Harris JK, Reeder R, Carpenter TC, Maddux AB, Leroue MK, Yehya N, DeRisi JL, Hall MW, Zuppa AF, Carcillo J, Meert K, Sapru A, Pollack MM, McQuillen P, Notterman DA, Langelier CR, Mourani PM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN): Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections. mSystems 10(1): e0133524, January 2025.
Lydon E, Osborne CM, Wagner B, Kirk Harris J, Carpenter T, Maddux A, Leroue M, Kamm J, Yehya N, Ambroggio L, Langelier C, Mourani P, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN): Tracheal aspirate and plasma proteomics reveals the local and systemic host immune response to severe pediatric lower respiratory viral infections. mSystems 10(1): e0133524, January 2025.
Osborne CM: "Principles of antimicrobial therapy" in Comprehensive Critical Care: Pediatric 3rd Edition. Society of Critical Care Medicine. Mejia R, Ahmad A (eds.). 2025.
Osborne CM, Chiotos K, Woods-Hill CZ: Diagnostic challenges associated with the prevalence of concurrent serious bacterial infection in children with bronchiolitis. Hospital Pediatrics 14(8): e355-e357, August 2024.
Osborne CM, Langelier C, Kamm J, Williamson K, Ambroggio LA, Reeder RW, Locandro C, Harris JK, Sontag MK, Wagner BD, Maddux AB, Caldera S, Lyden A, Soesanto V, Simões EAF, Leroue MK, Carpenter TC, Hall MW, Zuppa AF, Carcillo JA, Meert KL, Sapru A, Pollack MM, McQuillen PS, Notterman DA, Dean JM, DeRisi J, Mourani PM, NICHD Collaborative Pediatric Critical Care Research Network: Viral Detection by Reverse Transcriptase Polymerase Chain Reaction in Upper Respiratory Tract and Metagenomic RNA Sequencing in Lower Respiratory Tract in Critically Ill Children With Suspected Lower Respiratory Tract Infection. Pediatr Crit Care Med 25(1): e1-e11, January 2024.
Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar K, Glascock A, Osborne CM, Wagner BD, Matthay M, DeRisi JL, Calfee CS, Mourani PM, Langelier CR: The antibiotic resistance reservoir of the lung microbiome expands with age. Nature Communications 15: 92, January 2024.
Ho EC, Cataldi JR, Silveira LJ, Birkholz M, Loi MM, Osborne CM, Dominguez SR: Outbreak of Invasive Group A Streptococcus in Children-Colorado, October 2022-April 2023. J Ped Infect Dis 12(10): 540-548, October 2023.