Adam J Stevens, Ph.D.
Assistant Professor of Cancer Biology
Department: Cancer Biology
Contact information
421 Curie Blvd, BRB
Philadelphia, PA 19104
Philadelphia, PA 19104
Publications
Education:
B.A. (Chemistry)
Johns Hopkins University, Baltimore, MD, 2012.
Ph.D. (Chemistry)
Princeton University, Princeton, NJ, 2017.
Permanent linkB.A. (Chemistry)
Johns Hopkins University, Baltimore, MD, 2012.
Ph.D. (Chemistry)
Princeton University, Princeton, NJ, 2017.
Selected Publications
Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA: Programming Multicellular Assembly with Synthetic Cell Adhesion Molecules. Nature 614(7946): 144-152, Feb 2023.Sekar G, Stevens AJ, Mostafavi AZ, Sashi P, Muir TW, Cowburn D: A conserved histidine residue drives extein dependence in an enhanced atypically split intein. Journal of the American Chemical Society 144(41): 19196-19203, Oct 2022.
Shah NH, Stevens AJ: Identification, Characterization, and Optimization of Split Inteins. Methods in Molecular Biology 2133: 31-54, 2020.
Thompson RE, Stevens AJ, Muir TW: Protein engineering through tandem transamidation. Nature Chemistry 11: 737-743, Aug 2019.
Stevens AJ, Sekar G, Gramespacher JA, Cowburn D, Muir TW: An Atypical Mechanism of Split Intein Molecular Recognition and Folding. Journal of the American Chemical Society 140(37): 11791-11799, Sep 2018.
Gramespacher JA, Stevens AJ, Thompson RE, Muir TW: Improved Protein Splicing Using Embedded Split Inteins. Protein Science 27(3): 614-619, Mar 2018.
Stevens AJ, Sekar G, Shah NH, Mostafavi AZ, Cowburn D, Muir TW: A Promiscuous Split Intein with Expanded Protein Engineering Applications. Proceedings of the National Academy of Sciences U.S.A. 114(32): 8538-8543, Aug 2017.
Gramespacher JA, Stevens AJ, Nguyen DP, Chin JW, Muir TW: Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis. Journal of the American Chemical Society 139(24): 8074-8077, Jun 2017.
Stevens AJ, Brown ZZ, Shah NH, Sekar G, Cowburn D, Muir TW: Design of a Split Intein with Exceptional Protein Splicing Activity. Journal of the American Chemical Society 138(7): 2162-2165, Feb 2016.
Stevens AJ, Guan L, Bebenek K, Kunkel TA, Greenberg MM.: DNA Polymerase λ Inactivation by Oxidized Abasic Sites. Biochemistry 52(5): 975-983, Feb 2013.