Casey S. Greene, Ph.D.

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Adjunct Associate Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
13001 E 17th Pl
Office Q20-E1339
Aurora, CO 80045
Education:
B.S. (Chemistry)
Berry College, 2005.
Ph.D. (Computational Genetics)
Dartmouth College, 2009.
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Description of Research Expertise

Our overarching goal is to transform how we understand complex biological systems by developing and applying computational algorithms that effectively model processes by integrating multiple types of big data from diverse experiments. This allows us to infer the key contextual information required to interpret such data, and facilitates both the computationally driven asking and answering of basic science and translational research questions.

Selected Publications

Dang MT, Gonzalez MV, Gaonkar KS, Rathi KS, Young P, Arif S, Zhai L, Alam Z, Devalaraja S, To TKJ, Folkert IW, Raman P, Rokita JL, Martinez D, Taroni JN, Shapiro JA, Greene CS, Savonen C, Mafra F, Hakonarson H, Curran T, Haldar M.: Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality. Cell Rep 34: 108917, Mar 2021.

Cousminer DL, Wagley Y, Pippin JA, Elhakeem A, Way GP, Pahl MC, McCormack SE, Chesi A, Mitchell JA, Kindler JM, Baird D, Hartley A, Howe L, Kalkwarf HJ, Lappe JM, Lu S, Leonard ME, Johnson ME, Hakonarson H, Gilsanz V, Shepherd JA, Oberfield SE, Greene CS, Kelly A, Lawlor DA, Voight BF, Wells AD, Zemel BS, Hankenson KD, Grant SFA.: Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual. Genome Biol 22: 1, Jan 2021.

Mueller AC, Piper M, Goodspeed A, Bhuvane S, Williams JS, Bhatia S, Phan AV, Van Court B, Zolman KL, Peña B, Oweida AJ, Zakem S, Meguid C, Knitz MW, Darragh L, Bickett TE, Gadwa J, Mestroni L, Taylor MRG, Jordan KR, Dempsey P, Lucia MS, McCarter MD, Del Chiaro M, Messersmith WA, Schulick RD, Goodman KA, Gough MJ, Greene CS, Costello JC, Galvao Neto A, Lagares D, Hansen KC, Van Bokhoven A, Karam SD.: Induction of ADAM10 by RT drives fibrosis, resistance, and EMT in pancreatic cancer. Cancer Res ancer Res, 2021.

Lee AJ, Park Y, Doing G, Hogan DA, Greene CS.: Correcting for experiment-specific variability in expression compendia can remove underlying signals. Gigascience 9: giaa117, Nov 2020.

Allen William E, Altae-Tran Han, Briggs James, Jin Xin, McGee Glen, Shi Andy, Raghavan Rumya, Kamariza Mireille, Nova Nicole, Pereta Albert, Danford Chris, Kamel Amine, Gothe Patrik, Milam Evrhet, Aurambault Jean, Primke Thorben, Li Weijie, Inkenbrandt Josh, Huynh Tuan, Chen Evan, Lee Christina, Croatto Michael, Bentley Helen, Lu Wendy, Murray Robert, Travassos Mark, Coull Brent A, Openshaw John, Greene Casey S, Shalem Ophir, King Gary, Probasco Ryan, Cheng David R, Silbermann Ben, Zhang Feng, Lin Xihong: Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing. Nature human behaviour Aug 2020.

Talhouk Aline, George Joshy, Wang Chen, Budden Timothy, Tan Tuan Zea, Chiu Derek S, Kommoss Stefan, Leong Huei San, Chen Stephanie, Intermaggio Maria P, Gilks Blake, Nazeran Tayyebeh M, Volchek Mila, Elatre Wafaa, Bentley Rex C, Senz Janine, Lum Amy, Chow Veronica, Sudderuddin Hanwei, Mackenzie Robertson, Leong Samuel C Y, Liu Geyi, Johnson Dustin, Chen Billy, Group Aocs, Alsop Jennifer, Banerjee Susana N, Behrens Sabine, Bodelon Clara, Brand Alison H, Brinton Louise, Carney Michael E, Chiew Yoke-Eng, Cushing-Haugen Kara L, Cybulski Cezary, Ennis Darren, Fereday Sian, Fortner Renée T, García-Donas Jesús, Gentry-Maharaj Aleksandra, Glasspool Rosalind, Goranova Teodora, Greene Casey S, Haluska Paul, Harris Holly R, Hendley Joy, Hernandez Brenda Y, Herpel Esther, Jimenez-Linan Mercedes, Karpinskyj Chloe, Kaufmann Scott H, Keeney Gary L, Kennedy Catherine J, Köbel Martin, Koziak Jennifer M, Larson Melissa C, Lester Jenny, Lewsley Liz-Anne, Lissowska Jolanta, Lubiński Jan, Luk Hugh, Macintyre Geoff, Mahner Sven, McNeish Iain A, Menkiszak Janusz, Nevins Nikilyn, Osorio Ana, Oszurek Oleg, Palacios José, Hinsley Samantha, Pearce Celeste L, Pike Malcolm C, Piskorz Anna M, Ray-Coquard Isabelle, Rhenius Valerie, Rodriguez-Antona Cristina, Sharma Raghwa, Sherman Mark E, De Silva Dilrini, Singh Naveena, Sinn Peter, Slamon Dennis, Song Honglin, Steed Helen, Stronach Euan A, Thompson Pamela J, Tołoczko Aleksandra, Trabert Britton, Traficante Nadia, Tseng Chiu-Chen, Widschwendter Martin, Wilkens Lynne R, Winham Stacey J, Winterhoff Boris, Beeghly-Fadiel Alicia, Benitez Javier, Berchuck Andrew, Brenton James D, Brown Robert, Chang-Claude Jenny, Chenevix-Trench Georgia, deFazio Anna, Fasching Peter A, García María J, Gayther Simon A, Goodman Marc T, Gronwald Jacek, Henderson Michelle J, Karlan Beth Y, Kelemen Linda E, Menon Usha, Orsulic Sandra, Pharoah Paul D P, Wentzensen Nicolas, Wu Anna H, Schildkraut Joellen M, Rossing Mary Anne, Konecny Gottfried E, Huntsman David G, Huang Ruby Yun-Ju, Goode Ellen L, Ramus Susan J, Doherty Jennifer A, Bowtell David D, Anglesio Michael S: Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE). Clinical cancer research : an official journal of the American Association for Cancer Research Jun 2020.

Way, GP, Zietz, M, Rubinetti, V, Himmelstein, DS, Greene, CS: Compressing gene expression data using multiple latent space dimensionalities learns complementary biological representations. Genome Biology 21(1), MAY 11 2020.

Hu Qiwen, Greene Casey S, Heller Elizabeth A: Specific histone modifications associate with alternative exon selection during mammalian development. Nucleic acids research 48(9): 4709-4724, May 2020.

Clay, ME, Hammond, JH, Zhong, FF, Chen, XL, Kowalski, CH, Lee, AJ, Porter, MS, Hampton, TH, Greene, CS, Pletneva, EV, Hogan, DA: Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin. Proceedings of the national academy of sciences of the united states of america 117(6): 3167-3173, FEB 11 2020.

Banerjee, J, Allaway, RJ, Taroni, JN, Baker, A, Zhang, XC, Moon, CI, Pratilas, CA, Blakeley, JO, Guinney, J, Hirbe, A, Greene, CS, Gosline, SJC: Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1. Genes 11(2), FEB 2020.

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Last updated: 06/02/2021
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