Michael S. Haney, Ph.D.
Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Department of Pathology and Laboratory Medicine
University of Pennsylvania
Stellar - Chance Laboratories, 6th Floor
Philadelphia, PA 19104
University of Pennsylvania
Stellar - Chance Laboratories, 6th Floor
Philadelphia, PA 19104
Education:
B.A. (Molecular and Cell Biology)
University of California, Berkeley, 2010.
Ph.D. (Genetics)
Stanford University School of Medicine, 2018.
Permanent linkB.A. (Molecular and Cell Biology)
University of California, Berkeley, 2010.
Ph.D. (Genetics)
Stanford University School of Medicine, 2018.
Description of Research Expertise
Alzheimer's diseaseCRISPR Screens
Functional Genomics
Neuroimmunology
Microglia
Neurodegeneration
Aging
Hematopoiesis
Selected Publications
Haney MS, Pálovics R, Munson CN, Long C, Johansson P, Yip O, Dong W, Rawat E, West E, Schlachetzki JC, Tsai A, Guldner IH, Lamichhane BS, Smith A, Schaum N, Calcuttawala K, Shin A, Wang YH, Wang C, Koutsodendris N, Serrano GE, Beach TG, Reiman EM, Glass CK, Abu-Remaileh M, Enejder A, Huang Y, Wyss-Coray T.: APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia. BioRxiv no volume(no issue): no pages, Jul 2023 Notes: Preprint.Hamilton Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Patricia Moran-Losada, Divya Channappa, Deniz Urey, Kate Kim, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Dan Western, Ellen Liu, Pat Kohlfeld, John Budde, Edward N. Wilson, Yann Guen, Michael Haney, Andrew C. Yang, Taylor M. Maurer, Sanish Sathyan, Zihuai He, Michael Greicius, Katrin I. Andreasson, Erica F. Weiss, Stephen B. Montgomery, Sofiya Milman, Nir Barzilai, Anthony Wagner, Elizabeth Mormino, Carlos Cruchaga, Benoit Lehallier, Victor W. Henderson, Frank Longo, Tony Wyss-Coray.: Organ aging signatures in the plasma proteome track health and disease. Nature (In Press) no volume(no issue): no pages, no month 2023 Notes: Manuscript accepted and in press.
Michael S Haney, Archana Shankar, Ian Hsu, Masashi Miyauchi, Robert Palovics, Hwei Minn Khoo, Kyomi J Igarashi, Joydeep Bhadury, Christy Munson, Paul K Mack, Tze-Kai Tan, Tony Wyss-Coray, Hiromitsu Nakauchi, Adam C Wilkinson: Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging. BioRxiv no volume(no issue): no pages, July 2022 Notes: Preprint.
Iram T, Kern F, Kaur A, Myneni S, Morningstar AR, Shin H, Garcia MA, Yerra L, Palovics R, Yang AC, Hahn O, Lu N, Shuken SR, Haney MS, Lehallier B, Iyer M, Luo J, Zetterberg H, Keller A, Zuchero JB, Wyss-Coray T.: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17. Nature 605(7910): 509-515, May 2022.
Vest RT, Chou CC, Zhang H, Haney MS, Li L, Laqtom NN, Chang B, Shuken S, Nguyen A, Yerra L, Yang AC, Green C, Tanga M, Abu-Remaileh M, Bassik MC, Frydman J, Luo J, Wyss-Coray T.: Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration. Proc Natl Acad Sci U S A 119(11): e2121609119, March 2022.
Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A; Tabula Muris Consortium; Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T.: Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature 603(7900): 309-314, March 2022 Notes: Member of the Tabula Muris Consortium.
Pluvinage JV, Sun J, Claes C, Flynn RA, Haney MS, Iram T, Meng X, Lindemann R, Riley NM, Danhash E, Chadarevian JP, Tapp E, Gate D, Kondapavulur S, Cobos I, Chetty S, Pașca AM, Pașca SP, Berry-Kravis E, Bertozzi CR, Blurton-Jones M, Wyss-Coray T.: The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Science Translational Medicine 13(62): eabg2919, December 2021.
Li Q, Haney MS.: The role of glia in protein aggregation. Neurobiology of Disease 143(No issue): 105015, Sep 2020.
Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium; Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T.: Ageing hallmarks exhibit organ-specific temporal signatures. Nature 583(7817): 596-602, July 2020 Notes: Member of the Tabula Muris Consortium.
Tabula Muris Consortium.: A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature 583(7817): 590-595, July 2020 Notes: Member of the Tabula Muris Consortium.