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Jonathan Schug
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Adjunct Assistant Professor of Genetics
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Technical Director, Next-Generation Sequencing Core/Functional Genomics Core, University of Pennsylvania
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Department: Genetics
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Contact information
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12-156 Smilow Center for Translational Research
39 3400 Civic Center Blvd
Philadelphia, PA 19104
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39 3400 Civic Center Blvd
Philadelphia, PA 19104
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Office: 215 898 0773
3e Lab: 215 898 0772
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3e Lab: 215 898 0772
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Education:
21 7 BA 18 (Mathematics) c
33 University of Pennsylvania, 1980.
21 8 MSE 2d (Computer and Information Science) c
33 University of Pennsylvania, 1995.
21 8 PhD 2d (Computer and Information Science) c
33 University of Pennsylvania, 2005.
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Permanent link21 7 BA 18 (Mathematics) c
33 University of Pennsylvania, 1980.
21 8 MSE 2d (Computer and Information Science) c
33 University of Pennsylvania, 1995.
21 8 PhD 2d (Computer and Information Science) c
33 University of Pennsylvania, 2005.
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161 Condon, D. E., Tran, P. V., Lien, Y. C., Schug, J., Georgieff, M. K., Simmons, R. A., Won, K. J.: Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus. BMC Bioinformatics 19(1): 31, 2018.
246 Serr, I., Scherm, M. G., Zahm, A. M., Schug, J., Flynn, V. K., Hippich, M., Kalin, S., Becker, M., Achenbach, P., Nikolaev, A., Gerlach, K., Liebsch, N., Loretz, B., Lehr, C. M., Kirchner, B., Spornraft, M., Haase, B., Segars, J., Kuper, C., Palmisano, R., Waisman, A., Willis, R. A., Kim, W. U., Weigmann, B., Kaestner, K. H., Ziegler, A. G., Daniel, C.: A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Sci Transl Med 10(422), 2018.
155 Nam, K. N., Wolfe, C. M., Fitz, N. F., Letronne, F., Castranio, E. L., Mounier, A., Schug, J., Lefterov, I., Koldamova, R.: Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice. Biochim Biophys Acta 1864(1): 152-161, 2018.
15e Gazala, S. A., Horwitz, E., Ben-Haroush Schyr, R., Bardugo, A., Israeli, H., Hija, A., Schug, J., Shin, S., Dor, Y., Kaestner, K. H., Ben-Zvi, D.: Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity. Diabetes 2018.
16f Castranio, E. L., Mounier, A., Wolfe, C. M., Nam, K. N., Fitz, N. F., Letronne, F., Schug, J., Koldamova, R., Lefterov, I.: Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury. Neurobiol Dis 105: 1-14, 2017.
17f Nam, K. N., Mounier, A., Wolfe, C. M., Fitz, N. F., Carter, A. Y., Castranio, E. L., Kamboh, H. I., Reeves, V. L., Wang, J., Han, X., Schug, J., Lefterov, I., Koldamova, R.: Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer''s model mice. Sci Rep 7(1): 4307, 2017.
1ce Li, C., Ackermann, A. M., Boodhansingh, K. E., Bhatti, T. R., Liu, C., Schug, J., Doliba, N., Han, B., Cosgrove, K. E., Banerjee, I., Matschinsky, F. M., Nissim, I., Kaestner, K. H., Naji, A., Adzick, N. S., Dunne, M. J., Stanley, C. A., De Leon, D. D.: Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets. Diabetes 66(7): 1901-1913, 2017.
164 Lahens, N. F., Ricciotti, E., Smirnova, O., Toorens, E., Kim, E. J., Baruzzo, G., Hayer, K. E., Ganguly, T., Schug, J., Grant, G. R.: A comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression. BMC Genomics 18(1): 602, 2017.
113 Galivo, F., Benedetti, E., Wang, Y., Pelz, C., Schug, J., Kaestner, K. H., Grompe, M.: Reprogramming human gallbladder cells into insulin-producing beta-like cells. PLoS One 12(8): e0181812, 2017.
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Selected Publications
174 Wang YJ, Traum D, Schug J, Gao L, Liu C; HPAP Consortium, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH.: Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes. Cell Metabolism. Cell Press, 29: 1-5, January 2019.161 Condon, D. E., Tran, P. V., Lien, Y. C., Schug, J., Georgieff, M. K., Simmons, R. A., Won, K. J.: Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus. BMC Bioinformatics 19(1): 31, 2018.
246 Serr, I., Scherm, M. G., Zahm, A. M., Schug, J., Flynn, V. K., Hippich, M., Kalin, S., Becker, M., Achenbach, P., Nikolaev, A., Gerlach, K., Liebsch, N., Loretz, B., Lehr, C. M., Kirchner, B., Spornraft, M., Haase, B., Segars, J., Kuper, C., Palmisano, R., Waisman, A., Willis, R. A., Kim, W. U., Weigmann, B., Kaestner, K. H., Ziegler, A. G., Daniel, C.: A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Sci Transl Med 10(422), 2018.
155 Nam, K. N., Wolfe, C. M., Fitz, N. F., Letronne, F., Castranio, E. L., Mounier, A., Schug, J., Lefterov, I., Koldamova, R.: Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice. Biochim Biophys Acta 1864(1): 152-161, 2018.
15e Gazala, S. A., Horwitz, E., Ben-Haroush Schyr, R., Bardugo, A., Israeli, H., Hija, A., Schug, J., Shin, S., Dor, Y., Kaestner, K. H., Ben-Zvi, D.: Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity. Diabetes 2018.
16f Castranio, E. L., Mounier, A., Wolfe, C. M., Nam, K. N., Fitz, N. F., Letronne, F., Schug, J., Koldamova, R., Lefterov, I.: Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury. Neurobiol Dis 105: 1-14, 2017.
17f Nam, K. N., Mounier, A., Wolfe, C. M., Fitz, N. F., Carter, A. Y., Castranio, E. L., Kamboh, H. I., Reeves, V. L., Wang, J., Han, X., Schug, J., Lefterov, I., Koldamova, R.: Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer''s model mice. Sci Rep 7(1): 4307, 2017.
1ce Li, C., Ackermann, A. M., Boodhansingh, K. E., Bhatti, T. R., Liu, C., Schug, J., Doliba, N., Han, B., Cosgrove, K. E., Banerjee, I., Matschinsky, F. M., Nissim, I., Kaestner, K. H., Naji, A., Adzick, N. S., Dunne, M. J., Stanley, C. A., De Leon, D. D.: Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets. Diabetes 66(7): 1901-1913, 2017.
164 Lahens, N. F., Ricciotti, E., Smirnova, O., Toorens, E., Kim, E. J., Baruzzo, G., Hayer, K. E., Ganguly, T., Schug, J., Grant, G. R.: A comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression. BMC Genomics 18(1): 602, 2017.
113 Galivo, F., Benedetti, E., Wang, Y., Pelz, C., Schug, J., Kaestner, K. H., Grompe, M.: Reprogramming human gallbladder cells into insulin-producing beta-like cells. PLoS One 12(8): e0181812, 2017.
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