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Gregory R Grant, Ph.D.
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Research Associate Professor of Genetics
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Director of Bioinformatics, Institute for Translational Medicine and Therapeutics (ITMAT)
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Department: Genetics
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Contact information
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10-111 Smilow Center for Translational Research
43 3400 Civic Center Boulevard
Philadelphia, PA 19104-6021
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43 3400 Civic Center Boulevard
Philadelphia, PA 19104-6021
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Office: 267-243-6111
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Publications
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Education:
21 7 BA 18 (Mathematics) c
41 University of Maryland, College Park, MD, 1988.
21 a Ph.D. 18 (Mathematics) c
41 University of Maryland, College Park, MD, 1995.
21 7 MA 1d (Computer Science) c
45 University of Pennsylvania, Philadelphia, PA, 1999.
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Permanent link21 7 BA 18 (Mathematics) c
41 University of Maryland, College Park, MD, 1988.
21 a Ph.D. 18 (Mathematics) c
41 University of Maryland, College Park, MD, 1995.
21 7 MA 1d (Computer Science) c
45 University of Pennsylvania, Philadelphia, PA, 1999.
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Description of Research Expertise
12d High Throughput Sequencing Analysis. Main focus is RNA-Sequencing. Expert in wide range of statistical methods in biology including study design and non-parametric methods. Expert in programming, transcriptomics, functional genomics, cancer genomics, microarray analysis, array CGH.26 29
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157 Aicher JK, Issakova D, Slaff B, Jewell S, Lahens NF, Grant GR, Baralle D, Rosenfeld JA, Scott DA; Undiagnosed Diseases Network; Bhoj EJ, Barash Y.: MAJIQ-CLIN: A novel tool for the identification of Mendelian disease-causing variants from RNA-Seq data. medRxiv Feb 2025.
a9 Yang J, Grant GR, Brooks TG.: Generating Correlated Data for Omics Simulation. bioRxiv Feb 2025.
132 Schwarz JE, Mrčela A, Lahens NF, Li Y, Hsu C, Grant GR, Skarke C, Zhang SL, Sehgal A.: Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms. Elife 12: RP88322, Nov 2024.
167 Ricciotti E, Tang SY, Mrčela A, Das US, Lordan R, Joshi R, Ghosh S, Aoyama J, McConnell R, Yang J, Grant GR, FitzGerald GA.: Disruption of the PGE(2) synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice. bioRxiv Sep 2024.
1c2 Tang SY, Lordan R, Meng H, Auerbach BJ, Hennessy EJ, Sengupta A, Das US, Joshi R, Marcos-Contreras OA, McConnell R, Grant GR, Ricciotti E, Muzykantov VR, Grosser T, Weiljie AM, FitzGerald GA.: Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice. Arterioscler Thromb Vasc Biol 44(6): 1393-1406, Jun 2024.
125 Theken KN, Ghosh S, Skarke C, Fries S, Lahens NF, Sarantopoulou D, Grant GR, FitzGerald GA, Grosser T.: Degree of Cyclooxygenase-2 Inhibition Modulates Blood Pressure Response to Celecoxib and Naproxen. medRxiv May 2024.
d1 Brooks TG, Lahens NF, Mrčela A, Grant GR.: Challenges and best practices in omics benchmarking. Nat Rev Genet 25(5): 326-339, May 2024.
117 Brooks TG, Lahens NF, Mrčela A, Sarantopoulou D, Nayak S, Naik A, Sengupta S, Choi PS, Grant GR.: BEERS2: RNA-Seq simulation through high fidelity in silico modeling. Brief Bioinform 25: bbae164, Mar 2024.
178 Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S.: Circadian regulation of lung repair and regeneration. JCI Insight 9: e179745, Mar 2024.
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Selected Publications
ff Brooks TG, Lahens NF, Mrčela A, Yang J, Purohit S, Naik A, Ricciotti E, Sengupta S, Choi PS, Grant GR.: Sources of non-uniform coverage in short-read RNA-Seq data. bioRxiv Feb 2025.157 Aicher JK, Issakova D, Slaff B, Jewell S, Lahens NF, Grant GR, Baralle D, Rosenfeld JA, Scott DA; Undiagnosed Diseases Network; Bhoj EJ, Barash Y.: MAJIQ-CLIN: A novel tool for the identification of Mendelian disease-causing variants from RNA-Seq data. medRxiv Feb 2025.
a9 Yang J, Grant GR, Brooks TG.: Generating Correlated Data for Omics Simulation. bioRxiv Feb 2025.
132 Schwarz JE, Mrčela A, Lahens NF, Li Y, Hsu C, Grant GR, Skarke C, Zhang SL, Sehgal A.: Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms. Elife 12: RP88322, Nov 2024.
167 Ricciotti E, Tang SY, Mrčela A, Das US, Lordan R, Joshi R, Ghosh S, Aoyama J, McConnell R, Yang J, Grant GR, FitzGerald GA.: Disruption of the PGE(2) synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice. bioRxiv Sep 2024.
1c2 Tang SY, Lordan R, Meng H, Auerbach BJ, Hennessy EJ, Sengupta A, Das US, Joshi R, Marcos-Contreras OA, McConnell R, Grant GR, Ricciotti E, Muzykantov VR, Grosser T, Weiljie AM, FitzGerald GA.: Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice. Arterioscler Thromb Vasc Biol 44(6): 1393-1406, Jun 2024.
125 Theken KN, Ghosh S, Skarke C, Fries S, Lahens NF, Sarantopoulou D, Grant GR, FitzGerald GA, Grosser T.: Degree of Cyclooxygenase-2 Inhibition Modulates Blood Pressure Response to Celecoxib and Naproxen. medRxiv May 2024.
d1 Brooks TG, Lahens NF, Mrčela A, Grant GR.: Challenges and best practices in omics benchmarking. Nat Rev Genet 25(5): 326-339, May 2024.
117 Brooks TG, Lahens NF, Mrčela A, Sarantopoulou D, Nayak S, Naik A, Sengupta S, Choi PS, Grant GR.: BEERS2: RNA-Seq simulation through high fidelity in silico modeling. Brief Bioinform 25: bbae164, Mar 2024.
178 Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S.: Circadian regulation of lung repair and regeneration. JCI Insight 9: e179745, Mar 2024.
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