Research in the Kamberov lab is directed at understanding how evolution has shaped humans, particularly the skin and skin derived organs such as sweat glands, hair follicles and mammary glands. A primary goal of our research is to define the genetic basis for the evolution of ancient human-specific traits such as the loss of fur and the expansion of sweat glands that are defining thermoregulatory adaptations of our species. Complementing these efforts, we are also interested in uncovering the phenotypic significance of genetic variation that is responsible for the diversity of modern humans, such as population level differences in sweat gland density, mammary composition and differential disease risk. Our work utilizes a highly interdisciplinary approach that combines classical and quantitative genetics in mice and humans with developmental biology and evolutionary genomics. Informed by our findings from evolutionary biology, we are undertaking efforts to improve human health and alleviate disease particularly in the areas of comprehensive skin regeneration and reproductive pathology.
Kamberov, Y. G., Karlsson, E. K., Kamberova, G. L., Lieberman, D. E., Sabeti, P. C., Morgan, B. A., Tabin, C. J.: A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A 112(32): 9932-7, 2015.
Kamberov, Y. G., Wang, S., Tan, J., Gerbault, P., Wark, A., Tan, L., Yang, Y., Li, S., Tang, K., Chen, H., Powell, A., Itan, Y., Fuller, D., Lohmueller, J., Mao, J., Schachar, A., Paymer, M., Hostetter, E., Byrne, E., Burnett, M., McMahon, A. P., Thomas, M. G., Lieberman, D. E., Jin, L., Tabin, C. J., Morgan, B. A., Sabeti, P. C.: Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell 152(4): 691-702, 2013.
Kamberov, Y. G., Kim, J., Mazitschek, R., Kuo, W. P., Whitman, M.: Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells. BMC Res Notes 4: 381, 2011 Notes: doi: 10.1186/1756-0500-4-381.
Cohen, E. D., Mariol, M. C., Wallace, R. M., Weyers, J., Kamberov, Y. G., Pradel, J., Wilder, E. L.: DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev Cell 2(4): 437-48, 2002.
Mizushima, T., Nakagawa, H., Kamberov, Y. G., Wilder, E. L., Klein, P. S., Rustgi, A. K.: Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells. Cancer Res 62(1): 277-82, 2002.
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Last updated: 06/12/2018
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