Department of Anesthesiology and Critical Care

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Maryellen Fazen Eckenhoff, PhD

Research Associate of Anesthesiology and Critical Care
Research Associate , Perelman School of Medicine
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
3620 Hamilton Walk
305 John Morgan
Philadelphia, PA 19104
Office: 215-573-8217
Fax: 215-349-5078
Education:
BS (Biomedical Engineering)
Northwestern University, 1975.
PhD (Anatomy and Cell Biology)
Northwestern University School of Medicine, 1979.
Post-Graduate Training
Postdoctoral Fellowship Neuroscience, Yale University School of Medicine, 1980-1984.
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Description of Research Expertise

Current research is focused on perioperative neurocognitive disorders in a vulnerable brain. Our recent studies have shown that surgery produces long-term cognitive impairment in pre-symptomatic Alzheimer mice, possibly due to the transient increase in neuroinflammation and an impaired immune response. However, this effect can be modulated by the anesthetic, with propofol resulting in less cognitive dysfunction than the inhaled anesthetic, isoflurane. In humans, we found significant changes in Alzheimer biomarkers in the CSF of older patients during the perioperative period. Further research is underway to examine ways to modulate neuroinflammation after surgery and major illness.

Selected Publications

Mardini F, Tang JX, Li JC, Arroliga MJ, Eckenhoff RG, Eckenhoff MF: Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model. Br J Anaesth. Elsevier, 119(3): 472-480, Sept 2017.

Tang Junxia X, Mardini Feras, Janik Luke S, Garrity Sean T, Li Rosie Q, Bachlani Gulnaz, Eckenhoff Roderic G, Eckenhoff Maryellen F: Modulation of murine Alzheimer pathogenesis and behavior by surgery. Annals of surgery 257(3): 439-48, Mar 2013.

Tang Junxia X, Baranov Dimitry, Hammond Mary, Shaw Leslie M, Eckenhoff Maryellen F, Eckenhoff Roderic G: Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology 115(4): 727-32, Oct 2011.

Tang Junxia X, Mardini Feras, Caltagarone Breanna M, Garrity Sean T, Li Rosie Q, Bianchi Shannon L, Gomes Olubusola, Laferla Frank M, Eckenhoff Roderic G, Eckenhoff Maryellen F: Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model. Alzheimer's & dementia : the journal of the Alzheimer's Association 7(5): 521-531.e1, Sep 2011.

Bianchi Shannon L, Tran Thuy, Liu Chuiliang, Lin Susan, Li Yujuan, Keller Jason M, Eckenhoff Roderic G, Eckenhoff Maryellen F: Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiology of aging 29(7): 1002-10, Jul 2008.

Eckenhoff Roderic G, Johansson Jonas S, Wei Huafeng, Carnini Anna, Kang Baobin, Wei Wenlin, Pidikiti Ravindernath, Keller Jason M, Eckenhoff Maryellen F: Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology 101(3): 703-9, Sep 2004.

Eckenhoff Maryellen Fazen, Chan Kin, Eckenhoff Roderic G: Multiple specific binding targets for inhaled anesthetics in the mammalian brain. The Journal of pharmacology and experimental therapeutics 300(1): 172-9, Jan 2002.

Eckenhoff M F, Eckenhoff R G: Quantitative autoradiography of halothane binding in rat brain. The Journal of pharmacology and experimental therapeutics 285(1): 371-6, Apr 1998.

Rakic P, Bourgeois J P, Eckenhoff M F, Zecevic N, Goldman-Rakic P S: Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. Science (New York, N.Y.) 232(4747): 232-5, Apr 1986.

Eckenhoff M F, Rakic P: Radial organization of the hippocampal dentate gyrus: a Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey. The Journal of comparative neurology 223(1): 1-21, Feb 1984.

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Last updated: 10/08/2018
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