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Penn Center for AIDS Research

Kyong-Mi Chang

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Professor of Medicine
Associate Dean for Research at Crescenz VAMC, Philadelphia, University of Pennsylvanina Perelman School of Medicine
Department: Medicine

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Lab: (215) 823-5800 ext 6730
Graduate Group Affiliations
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
Post-Graduate Training
General Surgery Internship, St. Francis Hospital/University of Connecticut, 1987-1988.
Family Practice Internship, Underwood Memorial Hospital/Thomas Jefferson University, Philadelphia, PA, 1988-1989.
Internal Medicine Residency, The Medical College of Pennsylvania, Philadelphia, PA, 1989-1992.
Gastroenterology Fellowship, Division of Gastroenterology, University of California at San Diego, 1992-1995.
NRSA Research Fellow (UCSD GI Division), Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1993-1995.
Research Associate/Sr Research Associate, Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1995-1999.
Certifications
Diplomate, National Board of Medical Examiners, 1988.
American Board of Internal Medicine, 1992.
Gastroenterology Board Certification, 1995.
Gastroenterology Board Recertification, 2016.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with a focus on human hepatitis C and B viruses, +/- HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also examining the genetic basis of cardio metabolic disorders including NAFLD using big data involving clinical and genetic data. Since 2020, Dr. Chang has actively engaged in research involving COVID-19 given her expertise in clinical research as well as virology/immune pathogenesis.

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research (e.g. via VA Career Development Award, VA Merit Review, Cooperative Studies Program and MVP research). She is also committed to mentoring VA-based researchers both locally and nationally.

Selected Publications

Marijana Vujkovic1,2,*, Shweta Ramdas3,*, Kim M. Lorenz1,3,4, Xiuqing Guo5, Rebecca Darlay6, Heather J. Cordell6, Jing He7, Yevgeniy Gindin8, Chuhan Chung8, Robert P. Myers8,9, Carolin V. Schneider3, Joseph Park2,3, Kyung Min Lee10, Marina Serper1,2, Rotonya M. Carr11, David E. Kaplan1,2, Mary E. Haas12, Matthew T. MacLean3, Walter R. Witschey13, Xiang Zhu14,15,16,17, Catherine Tcheandjieu14,18, Rachel L. Kember19,20, Henry R. Kranzler19,20, Anurag Verma1,3, Ayush Giri21, Derek M. Klarin14,22,23, Yan V. Sun24,25, Jie Huang26, Jennifer E. Huffman27, Kate Townsend Creasy3, Nicholas J. Hand3, Ching-Ti Liu28, Michelle T. Long29, Jie Yao5, Matthew Budoff30, Jingyi Tan5, Xiaohui Li5, Henry J. Lin5, Yii-Der Ida Chen5, Kent D. Taylor5, Ruey-Kang Chang5, Ronald M. Krauss31, Silvia Vilarinho32, Joseph Brancale32, Jonas B. Nielsen33, Adam E. Locke33, Marcus B. Jones33, Niek Verweij33, Aris Baras33, K. Rajender Reddy2, Brent A. Neuschwander-Tetri34, Jeffrey B. Schwimmer35, Arun J. Sanyal36, Naga Chalasani37, Kathleen A. Ryan38, Braxton D. Mitchell38, Dipender Gill39, Andrew D. Wells40,41, Elisabetta Manduchi3, Yedidya Saiman42, Nadim Mahmud43, Donald R. Miller44,45, Peter D. Reaven46,47, Lawrence S. Phillips24,48, Sumitra Muralidhar49, Scott L. DuVall10,50, Jennifer S. Lee14,18, Themistocles L. Assimes14,18,51, Saiju Pyarajan27,52,53, Kelly Cho27,52,53, Todd L. Edwards54,55, Scott M. Damrauer1,3,56, Peter W. Wilson24,57, J. Michael Gaziano27,52, Christopher J. O’Donnell27,52,53, Amit V. Khera23,53,58, Struan F. A. Grant3,59,60, Christopher D. Brown3, Philip S. Tsao14,18,51, Danish Saleheen61,62,63, Luca A. Lotta33, Lisa Bastarache7, Quentin M. Anstee64,65, Ann K. Daly65, James B. Meigs23,53,66, Jerome I. Rotter5, Julie A. Lynch10,50,67, Regeneron Genetics Center, Geisinger-Regeneron DiscovEHR Collaboration, EPoS Consortium, Daniel J. Rader2,3,*, Benjamin F. Voight1,3,4,68,*, and Kyong-Mi Chang1,2,*: A multi-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease, with histological and radiological validation. Nature Genetics 2022 (in press).

Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM, Wendt F, Wilson O, Greevy RA, Chung CP, Suzuki A, Ho YL, Akwo E, Polimanti R, Zhou J, Reaven P, Tsao PS, Gaziano JM, Huffman JE, Joseph J, Luoh SW, Iyengar S, Chang KM, Casas JP, Matheny ME, O'Donnell CJ, Cho K, Tao R, Susztak K, Robinson-Cohen C, Tuteja S, Siew ED; VA Million Veteran Program COVID-19 Science Initiative.: APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program. JAMA Intern Med 182: 386-395, Apr 2022.

Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat SM, Zhao H, Ritchie MD; VA Million Veteran Program COVID-19 Science Initiative, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O'Donnell C, Damrauer SM, Liao KP.: A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. PLoS Genet 18: e1010113, Apr 2022.

Clarke SL, Tcheandjieu C, Hilliard AT, Lee KM, Lynch J, Chang KM, Miller D, Knowles JW, O'Donnell C, Tsao PS, Rader DJ, Wilson PW, Sun YV, Gaziano JM, Assimes TL; VA Million Veteran Program.: Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure. Circ Genom Precis Med Apr 2022.

Bellomo TR, Bone WP, Chen BY, Gawronski KAB, Zhang D, Park J, Levin M, Tsao N, Klarin D, Lynch J, Assimes TL, Gaziano JM, Wilson PW, Cho K, Vujkovic M, O'Donnell CJ, Chang KM, Tsao PS, Rader DJ, Ritchie MD, Damrauer SM, Voight BF.: Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci. Front Genet 12: 787545, Feb 2022.

Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, et al.: The power of genetic diversity in genome-wide association studies of lipids. Nature Dec 2021.

Levin MG, Klarin D, Georgakis MK, Lynch J, Liao KP, Voight BF, O'Donnell CJ, Chang KM, Assimes TL, Tsao PS, Damrauer SM: A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease. Circ Res 129(10): 968-970, October 2021.

Shah S, Halvorson A, McBay B, Dorn C, Wilson O, Tuteja S, Chang KM, Cho K, Hauger R, Suzuki A, Hunt C, Siew E, Matheny M, Hung A, Greevy R, Roumie C.: Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort. Gut online ahead of print, October 2021.

Block TM, Chang KM, Guo JT: Prospects for the Global Elimination of Hepatitis B. Annu Rev Virol 8(1): 437-458, September 2021.

Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM: Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease. Circulation 144(5): 353-364, August 2021.

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Last updated: 05/23/2022
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