Penn Center for AIDS Research

Jonni S. Moore

faculty photo
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Director, Abramson Cancer Center Flow Cytometry and Cell Sorter Facility, University of Pennsylvania School of Medicine
member, Abrasion Cancer Center of the University of Pennsylvania
Director of Research Flow Cytometry, Department of Pathology and Laboratory Medicine
Executive Director, Path BioResource, Department of Pathology and Laboratory Medicine, Perleman School of Medicine
member, Institute for Immunology, Perleman School of Medicine
Diversity Search Advisor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine
PSOM Lead Diversity Search Advisor, Perelman School of Medicine, University of Pennsylvania
Senior Advisor, Clinical Flow Cytometry, Hospital of University of Pennsylvania
member, Parker Center for Cancer Immunotherapy
member, Immune Health Council, Perelman School of Medicine, University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-6853
Fax: (215) 898-4227
Graduate Group Affiliations
B.A. (Biology)
University of Virginia, Charlottesville, 1972.
Ph.D. (Microbiology)
Thomas Jefferson University, Philadelphia, 1984.
Post-Graduate Training
Postdoctoral Fellow, Immunology Graduate Group, Dr. Peter C. Nowell and Dr. Richard G. Hoover, University of Pennsylvania School of Medicine, 1984-1988.
Becton-Dickinson FACScan Key Operator, 1990.
Becton-Dickinson FACStar PLUS Key Operator, 1992.
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Description of Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently she has focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, Parker Institute for Cancer Immunotherapy
Mona Kumar, MD, Neurology

Selected Publications

Padrón LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, Gherardini PF, Karakunnel J, Mick R, Alanio C, Byrne KT, Hollmann TJ, Moore JS, Jones DD, Tognetti M, Chen RO, Yang X, Salvador L, Wherry EJ, Dugan U, O'Donnell-Tormey J, Butterfield LH, Hubbard-Lucey VM, Ibrahim R, Fairchild J, Bucktrout S, LaVallee TM, Vonderheide RH. : Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial Nat.Med. Nature Publishing Group, June 2022 Notes: doi: 10.1038/s41591-022-01829-9 Epub ahead of print.

Habertheuer, Andreas; Ram, Chirag; Schmierer, Maggie; Chatterjee, Shampa; Hu, Robert; Freas, Andrew; Zielinski, Patrick; Rogers, Wade; Silvestro, Eva M; McGrane, Michael; Moore, Jonni S; Korutla, Laxminarayana; Siddiqui, Sarmad; Xin, Yi; Rizi, Rahim; Qin Tao, Jian; Kreisel, Daniel; Naji, Ali; Ochiya, Takahiro; Vallabhajosyula, Prashanth: Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Transplantation 106 (4): 754-766, 2022.

Moore, J: Howard M. Shapiro: Remembering Cytometry's Muse. Cytometry Part A 99(12): 1169, December 2021 Notes: doi: 10.1002/cyto.a.24515.

Morchauser, A, Yang, Z, Murphy, W, Tian, S, Issadore, D, Moore, J. : Implementation of a single cell double-emulsion droplet assay in a shared resource laboratory. CytoVirtual Interactive 2021 June 2021 Notes: Presented as a video poster at virtual conference.

Jones,D, Schretzenmair, RD, Jakobowski, J, Brake-Silla, N, Peterson, T, Steichen, A, Wu, A, Balderas, R, Moore, J. : Development of a 35-color high parameter immune monitoring panel using a novel spectral cytometer. CytoVirtual Interactive 2021 June 2021 Notes: Video poster at virtual conferences.

Ionita, M, Rogers, W, Schretzenmair, R, Jones, D, Greenplate, A, Moore, J, Wang, L-S.: HitMapper: High throughput mapper for relational analysis of cell states. CytoVirtual Interactive 2021 June 2021 Notes: Presented as a video poster at virtual conference.

Habertheuer, Andreas MD, PhD1,2; Ram, Chirag BA1; Schmierer, Maggie MS3; Chatterjee, Shampa PhD4; Hu, Robert BA1; Freas, Andrew1; Zielinski, Patrick MS1; Rogers, Wade PhD3,5; Silvestro, Eva M. MLT, ASCP3,5; McGrane, Michael BS3; Moore, Jonni S. PhD5; Korutla, Laxminarayana PhD1,6; Siddiqui, Sarmad PhD,7; Xin, Yi PhD7; Rizi, Rahim MS, PhD7; Tao, Jian Qin MD4; Kreisel, Daniel MD, PhD8; Naji, Ali MD, PhD9; Ochiya, Takahiro PhD10; Vallabhajosyula, Prashanth MD, MS: Circulating donor lung-specific exosome profiles enable noninvasive monitoring of acute rejection in a rodent orthotopic lung transplantation model. Transplantation Page: online first, May 2021.

Fu W, Ho PC, Liu CL, Tzeng KT, Nayeem N, Moore JS, Wang LS, Chou SY: Reconcile the debate over protective effects of BCG vaccine against COVID-19. Sci Rep 11(1), April 2021 Notes: doi: 10.1038/s41598-021-87731-9.

Ionita M, Jones D, Moore J, Schretenmair R, Wang L-S, Rogers W.: Tailor: Targeting heavy tails in flow cytometry data with fast mixture modeling. Cytometry A 99(2): 133-144, February 2021 Notes: doi: 10.1002/cyto.a.24307.

Rogers W, Ionita M, Moore J: PanoplyCF: A New R Package for Manifold Learning Clustering via Binning. CYTO Virtual 2020 August 2020 Notes: Abstract accepted for poster presentation at CYTO Virtual 2020.

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Last updated: 06/17/2022
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