CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Lipid / Atherosclerosis / CAD / ACS / Prevention
CVI Research Description:
We have two projects related to lipid absorption and or transport that fit with the ACS Prevention Program.
Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X SealyI, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG, and Pack M : Identification of a Plant Isoflavonoid that Causes Biliary Atresia Science Translational Medicine 7(286): 286ra67, 2015.
Wilkins BJ, Gong W, Pack M: A novel keratin18 promoter that drives reporter gene expression in the
intrahepatic and extrahepatic biliary system allows isolation of cell-type
specific transcripts from zebrafish liver. Gene Expression Patterns 14(2): 62-68, 2014.
Wilkins BJ, Lorent K, Matthews RP, and Pack M: p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis. PLoS One 8(10): e77670, 2013.
Walters JA, Anderson JL, Bittman R, Pack M and Farber SA: Visualization of lipid metabolism in the larval zebrafish intestine reveals a relationship between NPC1L1 mediated cholesterol uptake and dietary fatty acids. Chemistry and Biology 19(7): 913-25, 2012.
Seiler C, Davuluri G, Abrams J, Byfield FJ, Janye PA and Pack M: Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biology 10(9): e1001385, 2012.
Abrams J, Davuluri G, Seiler C, Pack M: Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine. Neurogastroenterology and Motililty 24(3): 288-99, 2012.
Gao N, Davuluri G, Gong W, Seiler C, Furth EE, Kaestner K and Pack M : The Nuclear Pore Complex Proetin Elys is Required for Genome Stability in Mouse Intestinal Epithelial Progenitor Cells
Gastroenterology 140(5): 1547-1555, 2011.
Matthews RP, Eua Claire SF, Mungier M, Lorent K, Cui Shuang, Zhang Z, Russo P and Pack M : DNA Hypomethylation Causes Bile Duct Injury in Zebrafish and Is a Distinguishing Feature of Infantile Biliary Atresia
Hepatology 3(3): 905-14, 2011.
Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC and Pack M.: Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress. PLoS Genetics 4(10): e1000240, 2008.
Yee NS, Gong W, Huang Y, Lorent K, Dolan AC, Maraia RJ and Pack M: Mutation of RNA Polymerase III Subunit rpc2/polr3b Leads to Deficiency of the RNA Cleavage Subunit, Rpc11/Polr3k, and Disrupts Zebrafish Digestive System Development. PLOS Biology 5(11): e312, 2007.
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Last updated: 09/23/2016
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