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Thomas P. Cappola, MD, ScM

William Smilow Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Perelman Center for Advanced Medicine
Division of Cardiovascular Medicine
11-113 South Pavilion
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-3140
Fax: 215-349-8017
Lab: 215-573-4717
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
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Selected Publications

Spurrell CH, Barozzi I, Kosicki M, Mannion BJ, Blow MJ, Fukuda-Yuzawa Y, Slaven N, Afzal SY, Akiyama JA, Afzal V, Tran S, Plajzer-Frick I, Novak CS, Kato M, Lee EA, Garvin TH, Pham QT, Kronshage AN, Lisgo S, Bristow J, Cappola TP, Morley MP, Margulies KB, Pennacchio LA, Dickel DE, Visel A: Genome-wide fetalization of enhancer architecture in heart disease. Cell Rep. 40(12): 111400, Sep 2022.

Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z , Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal M, Gordon DA, Ramirez-Valle F, Cappola TP: Endotrophin, a collagen VI formation–derived peptide, in heart failure. NEJM Evidence 1(9): EVIDoa2200091, Sep 2022.

Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, Arany Z: Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nat Cardiovasc Res 1: 817-829, Sep 2022.

Javaheri A, Diab A, Zhao L, Qian C, Cohen JB, Zamani P, Kumar A, Wang Z, Ebert C, Maranville J, Kvikstad E, Basso M, van Empel V, Richards AM, Doughty RN, Rietzschel E, Kammerhoff K, Gogain J, Schafer P, Seiffert DA, Gordon DA, Ramirez-Valle F, Mann DL, Cappola TP, Chirinos JA: Proteomic analysis of effects of spironolactone in heart failure with preserved ejection fraction. Circ Heart Fail 15(9): e009693, Aug 2022.

Reza N, Edwards JJ, Katcoff H, Mondal A, Griffis H, Rossano JW, Lin KY, Holzhauser HL, Wald JW, Owens AT, Cappola TP, Birati EY, Edelson JB: Sex differences in left ventricular assist device-related emergency department encounters in the United States. J Card Fail 28(9): 1445-1455, May 2022.

Lumbers RT, Shah S...Cappola TP, Ellinor PT, Vasan RS, Smith JG: The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Fail 8(6): 5531-5541, Dec 2021.

McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC Jr, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.: Truncated titin proteins in dilated cardiomyopathy. Sci Transl Med 13(618): eabd7287, Nov 2021.

Parcha V, Patel N, Musunuru K, Margulies KB, Cappola TP, Halade G, Wang TJ, Arora G, Arora P: Natriuretic peptide deficiency in obese individuals: mechanistic insights from healthy organ donor cohort. J Am Coll Cardiol 77(24): 3138-3140, Jun 2021.

Parcha V, Patel N, Gutierrez OM, Li P, Gamble KL, Musunuru K, Margulies KB, Cappola TP, Wang TJ, Arora G, Arora P.: Chronobiology of natriuretic peptides and blood pressure in lean and obese individuals. J Am Coll Cardiol 77(18): 2291-2303, May 2021.

Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM, Arany Z; IMAC-2 and IPAC investigators.: Genetic and phenotypic landscape of peripartum cardiomyopathy. Circulation Apr 2021.

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Last updated: 01/16/2023
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