Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

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Joseph H. Gorman, III, MD

Professor of Surgery
Department: Surgery

Contact information
Gorman Cardiovascular Research Group
Glenolden Research Laboratory
500 S. Ridgeway Avenue
Glenolden, PA 19036
Office: 267-350-9616
Fax: 267-350-9627
B.S.Ch.E. (Chemical Engineering and Chemistry )
(Magna Cum Laude)Newark College of Engineering, New Jersey Institute of Technology, Newark, New Jersey of Engineering, Department of Chemical Engineering and Chemistry, Newark, NJ , 1984.
B.S.Ch.E (Chemical Engineering and Chemistry)
Newark College of Engineering, Graduate School of Engineering, New Jersey Institute of Technology, Newark, New Jersey, 1985.
University of Medicine and Dentistry of New Jersey/ Robert Wood Johnson Medical School, New Brunswick, NJ, 1991.
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Description of CVI Expertise

CVI Program Unit(s):
Myocyte Biology / Heart Failure

CVI Research Description:
The Gorman Cardiovascular Research Group is funded by several NIH grants, philanthropic grants and industrial contracts. This spring the group will be moving to a new facility in Glenolden Pennsylvania.

That facility will include:
Three large animal operating rooms, a cath lab, MRI, 3D echocardiography
capabilities as well as vastly expanded wet lab and office space.

The Group's Research interests include:
1) Pathophysiology of heart failure (HF)
2) Novel pharmacologic therapy for treating HF
3) Effect of left ventricular assist devices on ventricular remodeling and HF
4) Scientific evaluation of surgical procedures/devices in the treatment of HF
5) Cardiac Imaging: MRI & real time 3D echocardiography
6) Mitral valve physiology
7) Design of novel annuloplasty rings
8) Percutaneous valve repair/replacement
9) Anorexigen induced valve disease
10) Effect of selective ventricular pacing on HF
11) Development of material/processes to limit prosthetic valve calcification.

The Group collaborates with clinicians, cardiovascular scientists and engineers in both academia and industry to discover novel solutions to important cardiovascular disease.

Selected Publications

Vergnat M, Jassar AS, Jackson BM, Ryan LP, Eperjesi TJ, Pouch AM, Weiss SJ, Cheung AT, Acker MA, Gorman III JH, Gorman RC. : Ischemic Mitral Regurgitation: A Quantitative Three-Dimensional Echocardiographic Analysis. Annals of Thoracic Surgery 91: 157-164, 2011.

Matsubara M, Kanemoto S, Leshnower BG, Albone EF, Hinmon R, Plappert T, Gorman III JH, Gorman RC.: Single Dose GLP=1=Tf Ameliorates Myocardial Ischemia/Reperfusion Injury. Journal of Surgical Research 165: 38-45, 2011.

Witchey WR, Pilla JJ, Ferrari G, Koomalsingh K, Harris M, Hinmon R, Zsido GA. : Rotating Frame Spin Lattice Relaxation In a Swine Model of Chronic Left Ventricular Myocardial Infarction. Magnetic Resonance in Medicine 64: 1454-1461, 2010.

Xu C, Pilla JJ, Blom AS, Isaac G, Gorman III JH, Gorman RC, Dougherty L: Myocardial Deformation Analysis of 3D Tagged Cardiac Images Using an Optical Flow Method. Journal of Cardiovascular Magnetic Resonance 12(19), 2010.

Xu C, Brinster CJ, Jassar AS, Vergnat M, Eperjesi TJ, Gorman RC, Gorman III JH, Jackson BM.: A Novel Approach to in Vivo Mitral Valve Stress Analysis. Ameican Journal of Physiology 299: H1790-H1794, 2010.

Mahmood F, Gorman III JH, Subramanian B , Gorman RC, Panzica PJ, Hagberg RM, Lerner AB, Maslow A, Khabbaz KR. : Changes in Mitral Valve Annular Geometry After Repair Saddle Shaped vs. Flat Annuloplasty Rings. Annals of Thoracic Surgery 90: 1212-1220, 2010.

Matsubara M, Ranji M, Leshnower BG, Noma M, Ratcliffe SJ, Chance B, Gorman RC, Gorman III JH: In Vivo Fluorometric Assessment of Cyclosporine on Mitochondrial Function during Myocardial Ischemia and Reperfusion. Annals of Thoracic Surgery 89: 1532-1537, 2010.

Bouma W, Noma M, Kanemoto S, Matsubara M, Leshnower BG, Hinmon R, Gorman III JH, Gorman RC: Gender-Related Resistance to Myocardial Ischemia-Reperfusion Injury is Associated with High Constitutive ARC Expression. American Journal of Physiology 298: H1510-H1517, 2010.

Ifkovits JL, Tous E, Minakawa M, Morita M, Robb JD, Koomalsingh KJ, Gorman III JH, Gorman RC, Burdick JA: Injectable Hydrogel Properties Influence Extent of Post-Infarction Left Ventricular Remodeling in an Ovine Model. Proceedings of the National Academy of Science 107: 11507-11512, 2010.

Matsuzaki K, Morita M, Hamamoto H, Noma M, Robb JD, Gillespie MJ, Gorman III JH, Gorman RC: Annuloplasty for Ischemic Mitral Regurgitation does not Influence Long-Term Ventricular Remodeling. Annals of Thoracic Surgery 90: 788-795, 2010.

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Last updated: 08/25/2015
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