CVI Program Unit(s):
Myocyte Biology / Heart Failure
CVI Research Description:
The Gorman Cardiovascular Research Group
is funded by several NIH grants, philanthropic grants and industrial contracts. This spring the group will be moving to a new facility in Glenolden Pennsylvania.
That facility will include:
Three large animal operating rooms, a cath lab, MRI, 3D echocardiography
capabilities as well as vastly expanded wet lab and office space.
The Group's Research interests include:
1) Pathophysiology of heart failure (HF)
2) Novel pharmacologic therapy for treating HF
3) Effect of left ventricular assist devices on ventricular remodeling and HF
4) Scientific evaluation of surgical procedures/devices in the treatment of HF
5) Cardiac Imaging: MRI & real time 3D echocardiography
6) Mitral valve physiology
7) Design of novel annuloplasty rings
8) Percutaneous valve repair/replacement
9) Anorexigen induced valve disease
10) Effect of selective ventricular pacing on HF
11) Development of material/processes to limit prosthetic valve calcification.
The Group collaborates with clinicians, cardiovascular scientists and engineers in both academia and industry to discover novel solutions to important cardiovascular disease.
Branchetti E, Sainger R, Poggio P, Grau JB, Jeffery PF, Bavaria JB, Horny C, Lai E, Gorman III JH, Gorman RC, Levy RJ, Ferrari G.: Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: e66-e74, 2013.
Mahmood F, Kim H, Chaudary B, Bergman R, Matyal R, Gerstle J, Gorman III JH, Gorman RC, Khabbaz KR. : Tricuspid Annular Geometry: A Three-Dimensional Transesophageal Echocardiographic Study. Journal of Cardiothoracic and Vascular Anesthesia 27: 639-646, 2013.
Goldstone AB, Atluri P, Szeto WY, Trubelja A, Howard JL, MacArthur JW, Newcomb C, Donnelly JP, Kobrin DM, Sheridan MA, Powers C, Gorman RC, Gorman III JH, Pochettino A, Bavaria JB, Acker MA, Hargrove III WC, Woo YJ.: Minimally Invasive Approach Provides at Least Equivalent Results for Surgical Correction of Mitral Regurgitation: A Propensity Matched Comparison. Journals of Thoracic and Cardiovascular Surgery 145: 748-756, 2013.
Vergnat M, Levack MM, Jackson BM, Bavaria JE, Hermann HC, Cheung AT, Weiss SJ, Gorman III JH, Gorman RC.: The Effect of Surgical and Transcatheter Aortic Valve Replacement on Mitral Annular Anatomy. Annals of Thoracic Surgery 95: 614-620, 2013.
Siefert AW, Jimenez JH, Koomalsingh KJ, Aguel F, Shuto T, Snow TK, Gorman RC, Gorman III JH, Yoganathan AJ.: Contractile Mitral Annular Forces Are Reduced with Ischemic Mitral Regurgitation. Journal of Thoracic Surgery 146: 422-428, 2013.
Siefert AW, Touchton Jr. SA, McGarvey JR, Takebayashi S, Rabbah JP, Jimenez JH, Neelakantan S, Gorman RC, Gorman III JH, Yoganathan AP. : In-Vivo Mitral Annuloplasty Ring Transducer: Implications for Implantation and Annular Downsizing. Journal of Biomechanics. 46: 2550-2553, 2013.
McGarvey JR, Kondo N, Takebe M, Koomalsingh KJ, Witschey WRT, Takebayashi S,Shimaoka T, Gorman III JH, Gorman RC, Pilla JJ. : Directed Epicardial Assistance in Ischemic Cardiomyopathy: Flow and Function using Cardiac Magnetic Resonance Imaging. Annals of Thoracic Surgery 96: 577-585, 2013.
Levack MM, Bavaria JB, Gorman RC, Gorman III JH, Ryan LP. : Rapid Aortic Arch Debranching Using the Gore Hybrid Vascular Graft. Annals of Thoracic Surgery 95: e163-e165, 2013.
Gillespie MJ, Minakawa M, Morita M, Vergnat M, Koomalsingh KJ, Robb DJ, Kondo N, Shuto T, Takebe M, Shimaoka T, McGarvey JR, Gorman RC, Gorman III JH.: Sutureless Mitral Valve Replacement: Initial Steps toward a Percutaneous Procedure. Annals of Thoracic Surgery 96: 670-674, 2013.
Sainger R, Grau JB, Branchetii E, Poggio P, Lai E, Koka E, Vernick WJ, Gorman III JH, Gorman RC, Bavaria JB, Ferrari G.: Comparison of Transesophageal Echocardiographic Analysis and Circulating Biomarker Expression Profile in Calcific Aortic Valve Disease. Journal of Heart Valve Disease 22: 156-165, 2013.
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Last updated: 05/25/2016
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