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J. Kevin Foskett, PhD

Isaac Ott Professor of Physiology
Department: Physiology

Contact information
Department of Physiology
University of Pennsylvania
Perelman School of Medicine
700D Clinical Research Bldg./ 6085
Philadelphia, PA 19104
Office: (215) 898-1354
Fax: (215) 573-2273
Duke University, 1974.
University of South Carolina, 1977.
University of California at Berkeley, 1981.
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Description of CVI Expertise

CVI Program Unit(s):
Channel Biology / Electrophysiology

CVI Research Description:
Calcium signaling; electrophysiology of inositol trisphosphate receptor Ca release channel; apoptosis; bioenergetics; molecular mechanisms of calcium uptake by mitochondria. Interest in moving all these areas into cardiovascular realm.

Selected Publications

Vais H, Mallilankaraman K, Mak DO, Hoff H, Payne R, Tanis JE, Foskett JK: EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter. Cell Rep 14(3): 403-10, Jan 2016.

Ma Z, Tanis JE, Taruno A, Foskett JK: Calcium homeostasis modulator (CALHM) ion channels. Pflugers Arch Nov 2015 Notes: e-pub ahead of print.

Mak DO, Cheung KH, Toglia P, Foskett JK, Ullah G: Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins. PLoS Comput Biol 11(10): e1004529, Oct 2015.

Tordoff MG, Aleman TR, Ellis HT, Ohmoto M, Matsumoto I, Shestopalov VI, Mitchell CH, Foskett JK, Poole RL: Normal Taste Acceptance and Preference of PANX1 Knockout Mice. Chem Senses 40(7): 453-9, Sep 2015.

Mak DO, Foskett JK: Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view. Cell Calcium 58(1): 67-78, Jul 2015.

Kevin Foskett J, Philipson B: The mitochondrial Ca2+ uniporter complex. J Mol Cell Cardiol. Elsevier Ltd. 78C: 3-8, Jan 2015.

Doonan PJ, Chandramoorthy HC, Hoffman NE, Zhang X, Cárdenas C, Shanmughapriya S, Rajan S, Vallem S, Chen X, Foskett JK, Cheung JY, Houser SR, Madesh M: LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation. FASEB J. 28(11): 4936-49, Nov 2014 Notes: Available on 2015/11/1.

Vingtdeux V, Tanis JE, Chandakkar P, Zhao H, Dreses-Werringloer U, Campagne F, Foskett JK, Marambaud P: Effect of the CALHM1 G330D and R154H human variants on the control of cytosolic Ca2+ and Aβ levels. PLoS One 9(11): e112484, Nov 2014.

Joseph, J. D., Y. Peng, MD, D.-O. D. Mak, K.-H. Cheung, H. Vais, J. K. Foskett and H. Wei: General Anesthetic Isoflurane Modulates Inositol 1,4,5-Trisphosphate Receptor Calcium Channel Opening. Anesthesiology 121(3): 528-37, Sept 2014.

149. Tordoff, M.G., H. T. Ellis, T. R. Aleman, A. Downing, P. Marambaud, J. K. Foskett, R. M. Dana and S. A. McCaughey: Salty Taste Deficits in CALHM1 Knockout Mice. Chemical Senses. Oxford University Press, 39(5): 515-28, Jul 2014.

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Last updated: 10/31/2018
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