Kurt R Brunden, Ph.D.

faculty photo
Research Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Center for Neurodegenerative Disease Research
University of Pennsylvania
3600 Spruce St.
3rd Floor Maloney Bldg.
Philadelphia, PA 19104
Office: 215-615-5262
Education:
B.S. (Biology/Health Chemistry)
Western Michigan University, 1980.
Ph.D. (Biochemistry)
Purdue University, 1985.
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Description of Research Expertise

Dr. Brunden oversees research programs directed towards the identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases.

Selected Publications

He Zhuohao, Guo Jing L, McBride Jennifer D, Narasimhan Sneha, Kim Hyesung, Changolkar Lakshmi, Zhang Bin, Gathagan Ronald J, Yue Cuiyong, Dengler Christopher, Stieber Anna, Nitla Magdalena, Coulter Douglas A, Abel Ted, Brunden Kurt R, Trojanowski John Q, Lee Virginia M-Y: Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature medicine 24(1): 29-38, Jan 2018 Notes: doi: 10.1038/nm.4443. Epub 2017 Dec 4.

Zhang B, Yao Y, Cornec A-S, Oukoloff K, James M, Koivula P, Trojanowski JQ, Smith AB III, Lee VM-Y, Ballatore C and Brunden KR: A brain-penetrant triazolopyrimidine enhances microtubule stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Mol. Neurodegen. 13: 59, 2018.

Monti L, Wang SC, Oukoloff K, Smith AB III, Brunden KR, Caffrey CR and Ballatore C : Brain-penetrant triazolopyrimidine and phenylpyrimidine microtubule stabilizers as potential leads to treat human African trypanosomiasis. ChemMedChem 13: 1751-1754, 2018.

Oukoloff K, Kovalevich J, Cornec A-S, Yao Y, Owyang ZA, James M, Trojanowski JQ, Lee VM-Y, Smith AB III, Brunden KR* and Ballatore C : Design, synthesis and evaluation of photactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines. Bioorg. Med. Chem. Lett. 28: 2180-2183, 2018.

Brunden Kurt R, Lee Virginia M-Y, Smith Amos B, Trojanowski John Q, Ballatore Carlo: Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs. Neurobiology of disease 105: 328-335, Sep 2017 Notes: No issue. doi: 10.1016/j.nbd.2016.12.021. Epub 2016 Dec 22.

Cornec Anne-Sophie, Monti Ludovica, Kovalevich Jane, Makani Vishruti, James Michael J, Vijayendran Krishna G, Oukoloff Killian, Yao Yuemang, Lee Virginia M-Y, Trojanowski John Q, Smith Amos B, Brunden Kurt R, Ballatore Carlo: Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of medicinal chemistry 60(12): 5120-5145, Jun 2017 Notes: doi: 10.1021/acs.jmedchem.7b00475. Epub 2017 Jun 8.

Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VM-Y, Trojanowski JQ, Ballatore C, Smith AB III and Brunden KR : Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathol. Comm. 4(1): 106, Sep 2016.

Guo JL, Buist A, Soares A, Callaerts K, Calafate S, Stevenaert F, Daniels JP, Zoll BE, Crowe A, Brunden KR, Moechers D and Lee V-MY: The dynamics and turnover of tau aggregates in cultured cells: insights into therapies for tauopathies. J. Biol. Chem. 291(25): 13175-13193, Jun 2016.

Kovalevich J, Cornec A-S, Yao Y, James M, Crowe A, Lee VM-Y, Trojanowski JQ, Smith AB III, Ballatore C and Brunden KR : Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer’s disease and related tauopathies. J. Pharm. Exp. Therap. 357(2): 432-450, May 2016 Notes: doi: 10.1124/jpet.115.231175. Epub 2016 Mar 15.

Lassalas Pierrik, Gay Bryant, Lasfargeas Caroline, James Michael J, Tran Van, Vijayendran Krishna G, Brunden Kurt R, Kozlowski Marisa C, Thomas Craig J, Smith Amos B, Huryn Donna M, Ballatore Carlo: Structure Property Relationships of Carboxylic Acid Isosteres. Journal of medicinal chemistry 59(7): 3183-203, Apr 2016 Notes: doi: 10.1021/acs.jmedchem.5b01963. Epub 2016 Mar 30.

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Last updated: 10/24/2019
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