Eric F. Joyce, Ph.D.

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Assistant Professor of Genetics
Core Member, Epigenetics Institute, University of Pennsylvania
Department: Genetics

Contact information
564 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
B.A. (Genetics and Microbiology)
Rutgers University, 2004.
Ph.D. (Microbiology and Molecular Genetics)
Rutgers University, 2010.
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Description of Research Expertise

The Joyce lab studies how chromosomes are functionally organized and folded in 3-D space and time. Our primary goal is to understand how the structure and position of chromosomes within the nucleus is established and inherited across cell divisions, and how dysfunctional organization contributes to genome instability. To this end, we develop and utilize technologies to visualize chromosomes and subchromosomal regions at single-cell resolution and in a high-throughput fashion. Our research takes advantage of both Drosophila and mammalian systems as models for chromosome function, which allows us to directly address the conservation and health relatedness of the mechanisms we discover.

Current Projects:
1. Spatial organization of the epigenome
2. Regulatory logic underlying condensin-mediated chromatin folding
3. High-throughput screening for novel pathways important for genome organization
4. Impact of aging on 3D organization

Rotation Projects: Please contact Eric for more details.

Selected Publications

Luppino JM, Field A, Nguyen SC, Park DS, Shah PP, Lan Y, Yunker R, Jain R, Adelman K, Joyce EF: NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression bioRxiv April 2022.

Park DS, Nguyen SC, Isenhart R, Shah PP, Kim W, Barnett RJ, Chandra A, Luppino JM, Harke J, Wai M, Yang R, Lan Y, Yoon S, Yunker R, Vahedi G, Phillips-Cremins JE, Jain R, Joyce EF.: High-throughput Oligopaint screen identifies druggable regulators of genome folding bioRxiv April 2022.

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R.: BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet Oct 2021.

Luppino, J. M., Park, D. S., Nguyen, S. C., Lan, Y., Xu, Z., Yunker, R., Joyce, E. F.: Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes. Nat Genet Jun 2020.

Luppino Jennifer M, Joyce Eric F: Single cell analysis pushes the boundaries of TAD formation and function. Current opinion in genetics & development 61: 25-31, Apr 2020.

Ren Wenqing, Medeiros Nicole, Warneford-Thomson Robert, Wulfridge Phillip, Yan Qingqing, Bian Joyce, Sidoli Simone, Garcia Benjamin A, Skordalakes Emmanuel, Joyce Eric, Bonasio Roberto, Sarma Kavitha: Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. Nature communications 11(1): 2219, May 2020.

Gozalo Alejandro, Duke Ashley, Lan Yemin, Pascual-Garcia Pau, Talamas Jessica A, Nguyen Son C, Shah Parisha P, Jain Rajan, Joyce Eric F, Capelson Maya: Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression. Molecular cell Nov 2019.

Rosin Leah F, Crocker Olivia, Isenhart Randi L, Nguyen Son C, Xu Zhuxuan, Joyce Eric F: Chromosome territory formation attenuates the translocation potential of cells. eLife 8, Nov 2019.

Erceg Jelena, AlHaj Abed Jumana, Goloborodko Anton, Lajoie Bryan R, Fudenberg Geoffrey, Abdennur Nezar, Imakaev Maxim, McCole Ruth B, Nguyen Son C, Saylor Wren, Joyce Eric F, Senaratne T Niroshini, Hannan Mohammed A, Nir Guy, Dekker Job, Mirny Leonid A, Wu C-Ting: The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos. Nature communications 10(1): 4486, Oct 2019.

Poleshko Andrey, Smith Cheryl L, Nguyen Son C, Sivaramakrishnan Priya, Wong Karen G, Murray John Isaac, Lakadamyali Melike, Joyce Eric F, Jain Raj, Epstein Jonathan A: H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. eLife 8, Oct 2019.

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Last updated: 11/04/2022
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