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Pablo G Cámara, PhD
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Associate Professor of Genetics
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Senior Fellow, Institute for Biomedical Informatics (IBI), Perelman School of Medicine
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Member, Center for AI and Data Science in Integrated Diagnostics, Perelman School of Medicine
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Member, Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine
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Faculty Search Advisor, Department of Genetics, Perelman School of Medicine
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Member, Center for Computational Biomedicine, Perelman School of Medicine
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Department: Genetics
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Graduate Group Affiliations
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Contact information
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D105 Richards Building
3a 3700 Hamilton Walk
Philadelphia, PA 19104-6145
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3a 3700 Hamilton Walk
Philadelphia, PA 19104-6145
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Office: 215-746-3545
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Education:
21 a B.Sc. 20 (Theoretical Physics) c
3e Universidad Autonoma de Madrid, Spain, 2002.
21 a Ph.D. 20 (Theoretical Physics) c
3e Universidad Autonoma de Madrid, Spain, 2006.
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Permanent link21 a B.Sc. 20 (Theoretical Physics) c
3e Universidad Autonoma de Madrid, Spain, 2002.
21 a Ph.D. 20 (Theoretical Physics) c
3e Universidad Autonoma de Madrid, Spain, 2006.
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Description of Research Expertise
35e Research in the Camara lab is focused on the development and application of innovative computational approaches to the study of cellular heterogeneity and its role in disease. To this end, we draw ideas from topology, geometry, statistics, physics, and computer science. Combining these approaches with the use of high-throughput single-cell technologies and large-scale population studies, we aim to achieve a better understanding of the cellular composition and cell-to-cell signaling networks of tumors in relation to their genomes. We are particularly interested in deciphering the cellular ecosystem and heterotypic signaling networks of tumors of the central nervous system, both in adults and children; however, we expect our methods to be of utility to a broader community and collaborate with groups working in related areas of research.e 29
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138 Zoga, K., Villiere, S., Tikiyani, V., Edwards-Cintron, F., Thokachichu, P., Nicodemus, P., Camara, P. G., Hart, M. P.: Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories. Genetics(iyaf156), 2025.
da Nguyen M. A., Camara, P. G.: Mapping clonal architecture and evolution in pediatric brain cancers. Cancer Research 85(23_Supplement): B008, 2025.
b8 Gunther, E., Camara, P. G.: Exploring the Structural Lexicon of the Proteome via Metric Geometry. bioRxiv 2025.
1bb Noller, K., Botsis, T., Camara, P. G., Ciotti, L., Cooper, L. A., Goecks, J., Griffith, M., Haas, B. J., Ideker, T., Karchin, R., Kontos, D., Lai, J., Marcus, D., Meyer, C. A., Naegle, K., Pati, S., Peters, B., Pratt, D., Raphael, B. J., Reich, M., Savova, G. K., Wright, C., Fertig, E. J., Bakas S.: Informatics at the frontier of cancer research. Cancer Research 2025.
c6 Camara, P. G.: Quantum information in Riemannian spaces. Journal of Physics A: Mathematical and Theoretical 58: 225304, 2025.
124 Aubin, R. G., Montelongo, J., Hu, R., Gunther, E., Nicodemus, P., Camara, P. G.: Clustering-independent estimation of cell abundances in bulk tissues using single-cell RNA-seq data. Cell Reports Methods 4: 100905, 2024.
1d8 Bai, Z., Feng, B., McClory, S. E., Coutinho de Oliveira, B., Diorio, C., Gregoire, C., Tao, B., Yang, L., Zhao, Z., Peng, L., Sferruzza, G., Zhou, L., Zhou, X., Kerr, J., Baysoy, A., Su, G., Yang, M., Camara, P. G., Chen, S., Tang, L.*, June, C. H.*, Melenhorst, J. J.*, Grupp, S. A.*, Fan, R.*: Single-cell CAR T atlas reveals type2 function in 8-year leukemia remission. Nature 634: 702-711, 2024.
143 Govek, K. W., Nicodemus, P., Lin, Y., Crawford, J., Saturnino, A. B., Cui, H., Zoga, K., Hart, M. P., Camara, P. G.: CAJAL enables analysis and integration of single-cell morphological data using metric geometry. Nature Communications 14: 3672, 2023.
219 Bai, Z.*, Woodhouse, S.*, Zhao, Z., Arya, R., Govek, K., Kim, D., Lundh, S., Baysoy, A., Sun, H., Deng, Y., Xiao, Y., Barrett, D. M., Myers, R. M., Grupp, S. A., June, C. H., Fan, R.#, Camara, P. G.#, Melenhorst, J. J.#: Single-cell antigen-specific activation landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL. Science Advances 8: eabj2820, 2022 Notes: #corresponding authors. *authors contributed equally.
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Selected Publications
183 Wu, L., Nguyen, M. A., Yang, Z., Potluri, S., Sivagnanam, S., Kirchberger, N., Joshi, A., Ahn, K. J., Tumulty, J. S., Cruz Cabrera, E., Romberg, N., Tan., K., Coussens, L. M., Camara, P. G. : ImmunoPheno: A Computational Framework for Data-Driven Design and Analysis of Immunophenotyping Experiments. bioRxiv 2026.138 Zoga, K., Villiere, S., Tikiyani, V., Edwards-Cintron, F., Thokachichu, P., Nicodemus, P., Camara, P. G., Hart, M. P.: Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories. Genetics(iyaf156), 2025.
da Nguyen M. A., Camara, P. G.: Mapping clonal architecture and evolution in pediatric brain cancers. Cancer Research 85(23_Supplement): B008, 2025.
b8 Gunther, E., Camara, P. G.: Exploring the Structural Lexicon of the Proteome via Metric Geometry. bioRxiv 2025.
1bb Noller, K., Botsis, T., Camara, P. G., Ciotti, L., Cooper, L. A., Goecks, J., Griffith, M., Haas, B. J., Ideker, T., Karchin, R., Kontos, D., Lai, J., Marcus, D., Meyer, C. A., Naegle, K., Pati, S., Peters, B., Pratt, D., Raphael, B. J., Reich, M., Savova, G. K., Wright, C., Fertig, E. J., Bakas S.: Informatics at the frontier of cancer research. Cancer Research 2025.
c6 Camara, P. G.: Quantum information in Riemannian spaces. Journal of Physics A: Mathematical and Theoretical 58: 225304, 2025.
124 Aubin, R. G., Montelongo, J., Hu, R., Gunther, E., Nicodemus, P., Camara, P. G.: Clustering-independent estimation of cell abundances in bulk tissues using single-cell RNA-seq data. Cell Reports Methods 4: 100905, 2024.
1d8 Bai, Z., Feng, B., McClory, S. E., Coutinho de Oliveira, B., Diorio, C., Gregoire, C., Tao, B., Yang, L., Zhao, Z., Peng, L., Sferruzza, G., Zhou, L., Zhou, X., Kerr, J., Baysoy, A., Su, G., Yang, M., Camara, P. G., Chen, S., Tang, L.*, June, C. H.*, Melenhorst, J. J.*, Grupp, S. A.*, Fan, R.*: Single-cell CAR T atlas reveals type2 function in 8-year leukemia remission. Nature 634: 702-711, 2024.
143 Govek, K. W., Nicodemus, P., Lin, Y., Crawford, J., Saturnino, A. B., Cui, H., Zoga, K., Hart, M. P., Camara, P. G.: CAJAL enables analysis and integration of single-cell morphological data using metric geometry. Nature Communications 14: 3672, 2023.
219 Bai, Z.*, Woodhouse, S.*, Zhao, Z., Arya, R., Govek, K., Kim, D., Lundh, S., Baysoy, A., Sun, H., Deng, Y., Xiao, Y., Barrett, D. M., Myers, R. M., Grupp, S. A., June, C. H., Fan, R.#, Camara, P. G.#, Melenhorst, J. J.#: Single-cell antigen-specific activation landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL. Science Advances 8: eabj2820, 2022 Notes: #corresponding authors. *authors contributed equally.
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