Perelman School of Medicine at the University of Pennsylvania

Capell Lab

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OUR GROUP


PRINCIPAL INVESTIGATOR

Brian Capell, M.D. Ph.D.

Brian Capell, M.D. Ph.D.
Assistant Professor of Dermatology and Genetics
 brian.capell@uphs.upenn.edu

Brian is a physician-scientist and practicing dermatologist. Following a B.S. from Boston College, Brian entered medical school at the NYU School of Medicine. While there, he was accepted to the Howard Hughes Medical Institute (HHMI)-NIH Research Scholars Program, where he joined the lab of Dr. Francis Collins at the National Human Genome Research Institute. There, Brian studied the genetics of both normal and premature aging, in particular Hutchinson-Gilford progeria syndrome, earning his M.D. and Ph.D. from NYU. Following the completion of his Dermatology Residency at the University of Pennsylvania, Brian began a postdoctoral fellowship with Dr. Shelley Berger studying basic mechanisms of epigenetics and gene regulation. Brian is currently an Assistant Professor of Dermatology and Genetics and core faculty member of the Penn Epigenetics Institute and member of the Abramson Cancer Center.



LAB MEMBERS

Amy Anderson, M.S.

Amy Anderson, M.S.
Research Specialist C/Lab Manager
 amya2@mail.med.upenn.edu

Amy has a B.S. in Biology from Chatham University, as well as a M.S. from Drexel. She has extensive experience, having been working in research labs here at Penn for over 16 years. She is interested in the development and execution of cell and molecular-based research methods and mouse models along with laboratory management.


Yann Aubert, Ph.D.

Yann Aubert, Ph.D.
Postdoctoral Fellow / Bioinformatician
 yaubert@pennmedicine.upenn.edu

Yann obtained a Ph.D. in Plant Sciences from the University of Toulouse, France, in 2011, and further developed his experience in molecular biology as a postdoctoral researcher for 18 months in the Institute for Plant Molecular Biology in Strasbourg. His interest in the use of Next-Generation Sequencing techniques (NGS) led him to join the Lazar Lab at the Institute for Diabetes, Obesity and Metabolism as a research specialist, where he developed skills in the analysis of NGS data (RNAseq, ChIP-Seq). As a Postdoctoral Fellow in the Capell Lab, Yann is interested in the mining, exploration and representation of NGS data to elucidate the epigenetic mechanisms that drive the development of squamous cell carcinoma as well as in the investigation of new potential therapeutics to treat those types of cancer.


Shaun Egolf

Shaun Egolf
Graduate Student
 segolf@pennmedicine.upenn.edu

Shaun is a graduate student in the Cancer Biology PhD program at the University of Pennsylvania. He joined the Capell lab in the spring of 2018 as the lab’s first graduate student trainee. Shaun is broadly interested in applying genomics to study the epigenetic regulation of enhancers in epidermal homeostasis and carcinogenesis.


Eun Kyung Ko, Ph.D.

Eun Kyung Ko, Ph.D.
Postdoctoral Fellow
 EunKyung.Ko@uphs.upenn.edu

Eun Kyung obtained a Ph.D in Molecular Medicine from the Medical College of Georgia in 2018. She has been interested in the relationship between epigenetic mechanisms and cancer since her earlier Master’s work where she studied DNA methylation changes that occur at the earliest stages of cancer. Now, as a Postdoctoral Fellow in the Capell Lab, Eun aims to define the role of several uncharacterized, but targetable, histone modifying enzymes in both normal skin function and carcinogenesis, employing both in vitro and in vivo model systems.


Alexandra Maldonado-Lopez

Alexandra Maldonado-Lopez
Rotating Graduate Student
 Alexandra.Maldonado-Lopez@pennmedicine.upenn.edu

Alexandra is a graduate student in the Genetics and Epigenetics Ph.D. program at the University of Pennsylvania, with a B.S. from the University of Puerto Rico at Ponce. She is a rotating graduate student at the Capell Lab for Fall 2018. Alex is widely interested in the study of epigenetic modifications that regulate epidermal development and possible carcinogenesis.


Gina Pacella

Gina Pacella
Rotating Graduate Student
 Gina.Pacella@pennmedicine.upenn.edu

Gina is a graduate student in the Genetics and Epigenetics Ph.D. program at the University of Pennsylvania, with a B.S. from the University of Pittsburgh. She is a rotating graduate student in the lab this fall, and is broadly interested in the regulation of the genome by epigenetic modifiers and enhancer dynamics. 


Jonathan Zou

Jonathan Zou
Undergraduate Researcher
  jonzou@sas.upenn.edu

Jonathan is an undergraduate student at the University of Pennsylvania studying Biochemistry through the Vagelos Molecular Life Sciences program.



Lab Alumni

Maria Carrera

Maria Carrera
Undergraduate Researcher
 maria.carrera1@upr.edu

Maria is an undergraduate at the University of Puerto Rico-Mayaguez and spent the summer of 2018 in the Capell Lab studying the role epigenetic modifiers in epidermal homeostasis and carcinogenesis. She is now completing her senior year and will be returning to Penn as a graduate student in the Fall of 2018.