SELECTED PUBLICATIONS
PRIMARY LAB RESEARCH PAPERS:
Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
Ko EK, Anderson A, D'souza C, Zou J, Huang S, Cho S, Alawi F, Prouty S, Lee V, Yoon S, Krick K, Horiuchi Y, Ge K, Seykora JT, Capell BC. Developmental Cell. 59(2): 2024.
Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue
Maldonado López AM, Ko EK, Huang S, Pacella G, Kuprasertkul N, D'souza CA, Reyes Hueros RA, Shen H, Stoute J, Elashal H, Sinkfield M, Anderson A, Prouty S, Li HB, Seykora JT, Liu KF, Capell BC. Science Advances. 9(35): 2023.
MLL4 mediates differentiation and tumor suppression through ferroptosis
Egolf S, Zou J, Anderson A, Simpson CL, Aubert Y, Prouty S, Ge K, Seykora JT, Capell BC. Science Advances. 7(50): 2021.
LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors
Egolf S, Aubert Y, Doepner M, Anderson A, Maldonado-Lopez A, Pacella G, Lee J, Ko EK, Zou J, Lan Y, Simpson CL, Ridky T, Capell BC. Cell Reports. 28(8): 2019.
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
Lin-Shiao E, Lan Y, Coradin M, Anderson A, Donahue G, Simpson CL, Sen P, Saffie R, Busino L, Garcia BA, Berger SL, Capell BC. Genes & Development. 32(2): 2018.
MLL1 is essential for the senescence-associated secretory phenotype
Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL. MLL1 is essential for the senescence-associated secretory phenotype. Genes & Development. 30(3): 2016.
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Tavarez UL, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Avallone H, Kolodgie FD, Virmani R, Nabel EG, Collins FS. A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proceedings of the National Academy of Sciences USA. 105(41): 2008.
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proceedings of the National Academy of Sciences USA. 102(36): 2005.
COLLABORATIONS:
Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease
Zaver SA, Sarkar MK, Egolf S, Zou J, Tiwaa A, Capell BC, Gudjonsson JE, Simpson CL. JCI Insight. 2023 Aug 10:e170739. doi: 10.1172/jci.insight.170739. Epub ahead of print. PMID: 37561594.
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis
Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, Farria AT, Nguyen PTT, Murali N, Reich L, Kantner DS, Shaffer J, Affronti H, Carrer A, Andrews A, Capell BC, Snyder NW, Wellen KE. Science Advances. 9(18): 2023.
Endogenous DOPA inhibits melanoma through suppression of CHRM1 signaling
Doepner M, Lee I, Natale CA, Brathwaite R, Venkat S, Kim SH, Wei Y, Vakoc CR, Capell BC, Katzenellenbogen JA, Katzenellenbogen BS, Feigin ME, Ridky TW. Science Advances. 8(35): 2022.
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization
Huang S, Kuri P, Aubert Y, Brewster M, Li N, Farrelly O, Rice G, Bae H, Prouty S, Dentchev T, Luo W, Capell BC, Rompolas P. Cell Stem Cell. 28(9): 2021.
Whole exome and transcriptome analysis of UV-exposed epidermis and carcinoma in situ reveals early drivers of carcinogenesis
Zheng Q, Capell BC, Parekh V, O'Day C, Atillasoy C, Bashir HM, Yeh C, Shim EH, Prouty SM, Dentchev T, Lee V, Wushanley L, Kweon Y, Suzuki-Horiuchi Y, Pear W, Grice EA, Seykora JT. Journal of Investigative Dermatology. 141(2): 2021.
Pharmacologic activation of the G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma
Natale CA, Li J, Pitarresi JR, Norgard RJ, Dentchev T, Capell BC, Seykora JT, Stanger BZ, Ridky TW. Cellular and Molecular Gastroenterology and Hepatology. 10(4): 2020.
FBXW7 triggers degradation of KMT2D to favor growth of diffuse large B-cell lymphoma cells
Saffie R, Zhou N, Rolland D, Önder Ö, Basrur V, Campbell S, Wellen KE, Elenitoba-Johnson KSJ, Capell BC, Busino L. Cancer Research. 80(12): 2020.
REVIEW ARTICLES:
Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma
Hedberg ML, Berry CT, Moshiri AS, Xiang Y, Yeh CJ, Attilasoy C, Capell BC, Seykora JT. Int J Mol Sci. 23(7): 2022.
Methyltransferases in the Pathogenesis of Keratinocyte Cancers
Ko EK, Capell BC. Cancers. 13(14): 2021.
The METTL3-m 6 A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer
Maldonado López A, Capell BC. Genes. 12(7): 2021.
Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma
Pacella G, Capell BC. Experimental Dermatology. Apr 12. Epub ahead of print. 2021.
LSD1: a viable therapeutic target in cutaneous squamous cell carcinoma?
Egolf S, Capell BC. Expert Opinion on Therapeutic Targets. 24(7): 2020.
The Unexpected Noncatalytic Roles of Histone Modifiers in Development and Disease
Aubert Y, Egolf S, Capell BC. Trends in Genetics. 35(9): 2019.
Histone modifiers: Dynamic regulators of the cutaneous transcriptome
Ghosh K, O'Neil K, Capell BC. Histone modifiers: Dynamic regulators of the cutaneous transcriptome. Journal of Dermatological Science. Dec 18: 2017.
The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging
Ghosh K, Capell BC. The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging. Journal of Investigative Dermatology. 136(11): 2016.
Genome-wide epigenetics
Capell BC, Berger SL. Genome-wide epigenetics. Journal of Investigative Dermatology. 133(6): 2013.
From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging
Capell BC, Tlougan BE, Orlow SJ. From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging. Journal of Investigative Dermatology. 129(10): 2009.
Mechanisms of cardiovascular disease in accelerated aging syndromes
Capell BC, Collins FS, Nabel EG. Mechanisms of cardiovascular disease in accelerated aging syndromes. Circulation Research. 101(1): 2007.
Human laminopathies: nuclei gone genetically awry
Capell BC, Collins FS. Human laminopathies: nuclei gone genetically awry. Nature Reviews Genetics. 7(12): 2006.
COMMENTARIES:
Loss of TET2 Tips the Scales Toward Tumorigenesis
Capell BC. Journal of Investigative Dermatology. 142(in press): 2022.
From Enhancers to Keratinocyte Cancers
Capell BC. Journal of Investigative Dermatology. 141(5): 2021.
Loss of Methylation Modification Marks the Presence of Psoriasis
Capell BC, Seykora JT. Journal of Investigative Dermatology. 140(6): 2020.
Paget's Diseases: United by Epidermis and Epigenetics
Capell BC. Journal of Investigative Dermatology. 139(4): 2019.