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CVI Seminar Series
Weekly seminars hosted by the CVI
All CVI Seminars for Spring 2021 will be held at 4:00 PM virtually via Zoom. Click the link below to enter the event:
January 2021
January 13, 2021
Elizabeth McNally, MD, PhD
Northwestern University
"Genetic Determinants of Cardiac Function"
January 20, 2021
Li Qian, PhD
University of North Carolina
"Reprogramming Approach for Heart Repair"
January 27, 2021
Iris Jaffe, MD, PhD
Tufts University School of Medicine
"Vascular Mineralocorticoid Receptor: Evolutionary Mediator of Wound Healing Turned Harmful by our Modern Lifestyle"
February 2021
February 3, 2021
Jonathan Seidman, PhD
Harvard Medical School
"The Genetics of Inherited Heart Disease: From Mutation to Mechanism to Therapy"
February 10, 2021
Isha Jain, PhD
Gladstone Institutes and UCSF
"Turning the Oxygen and Vitamin Dials"
February 17, 2021
Michael Ostap, PhD
Perelman School of Medicine
"Mechanochemistry of Cardiac Myosin: Force, Cardiomyopathy Mutations, and Drugs"
February 24, 2021
Anne Eichmann, PhD
Yale School of Medicine
“Heterogeneity of Endothelial Barrier Function Unraveled”
March 2021
March 3, 2021
Arjun Deb, MD
UCLA Broad Stem Cell Research Center
“How Hearts Regulate Scar Size”
March 10, 2021
Siddhartha Jaiswal, MD, PhD
Stanford University
“Clonal Hematopoiesis and Risk of Cardiovascular Diseases”
Talk link: https://upenn.box.com/s/b27q31l8k186oafcchjwrug4jwomebwt
March 17, 2021
Pilar Alcaide, PhD, FAHA
Tufts University School of Medicine
"Understanding T-Cell Immune Responses in Heart Failure"
March 24, 2021
Orian Shirihai, MD, PhD
UCLA
“Social Life of Mitochondria Within the Cell”
March 31, 2021
Amita Sehgal, PhD
Perelman School of Medicine
“Circadian and Sleep Regulation of the Blood Brain Barrier”
April 2021
April 7, 2021
Mark Sellmyer, MD, PhD
Perelman School of Medicine
"Chemical Tools to Image and Control Gene/Cell Therapies"
April 14, 2021
Richard Lee, MD
Harvard University
"Will We be Able to Regenerate Hearts?"
April 21, 2021
Jorge Henao-Mejia, MD, PhD
Perelman School of Medicine
"RNA Regulation of Inflammation"
April 28, 2021
Maria Kontaridis, PhD
Masonic Medical Research Institute
"Heart Disease: From Pediatric to Heart Failure"
May 2021
May 5, 2021
Golnaz Vahedi, MSc, PhD
Perelman School of Medicine
"Multiomics Single-Cell Analysis of Human Pancreatic Islets Reveals Novel Cellular States in Health and Type 1 Diabetes"
May 12, 2021
CVI Dream Team Initiative
Perelman School of Medicine
Mark Kahn, MD
John Welsh, PhD
Talk Link: https://upenn.box.com/s/ry9sr14ancwiimczt2aemmt67svhrvk4
May 19, 2021
Slava Epelman, MD, PhD, FRCPC
University of Toronto
“Cardiac Macrophages - Is the Sum Greater Than Its Parts?”
A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z
A
Zoltan Arany, M.D., Ph.D.
Perelman School of Medicine
New Players in Mitophagy
December 12, 2018
Euan Ashley, M.D.
Stanford University
1 to 100,000 Single Cells to Populations in Cardiovascular Genomics
February 28, 2018
B
Robert Balaban, Ph.D.
National Heart, Lung, and Blood Institute
The Mitochondria Reticulum of Muscle Cells
December 11, 2019
Gerd Blobel, M.D., Ph.D.
Perelman School of Medicine
Genome and Epigenome Editing to Treat Hemoglobinopathies
March 14, 2018
Laurie Boyer, Ph.D.
Massachusetts Institute of Technology
Programming and Reprogramming Cardiac Cell Fate
January 31, 2018
Paul Burridge, Ph.D.
Northwestern University
Pharmacogenomic Prediction and Prevention of Chemotherapy-Induced Cardiotoxicity using hiPSC
January 16, 2019
Benoit Bruneau, Ph.D.
Gladstone Institute of Cardiovascular Disease
Transcriptional Regulation of Heart Development and Congenital Heart Disease
December 16, 2020
RECORDING: https://mediasite.med.upenn.edu/mediasite/Play/142edd19adfe4641be5f89d059386d901d
C
Thomas Cappola, M.D., Sc.M.
Perelman School of Medicine
Crossing the Translational Divide in Heart Failure
November 20, 2019
Kathleen Caron, Ph.D.
UNC-Chapel Hill
GPCR Regulation of Lymphatics in Health and Disease
February 13, 2019
Mete Civelek, Ph.D.
University of Virginia
Genetic Regulation of Vascular Smooth Muscle Cell Function
March 4, 2020
Kieran Clarke, Ph.D.
University of Oxford
A Ketone Drink for Heart Failure?
February 27, 2019
Kareen Coulombe, Ph.D.
Brown University
Re-Engineering Myocardium for Heart Regeneration
January 29, 2020
Peter Crawford, M.D., Ph.D.
University of Minnesota
Following Ketone Carbon Through Macrophages, Landing in Hepatic Fibrogenesis
January 30, 2019
D
Jennifer Davis, Ph.D.
University of Washington
Regulated of Cardiac Fibroblast Fate and Fibrosis
November 11, 2020
Sharlene Day, M.D.
Perelman School of Medicine
Understanding Hypertrophic Cardiomyopathy: From Molecule to Patient
December 9, 2020
RECORDIG: https://mediasite.med.upenn.edu/mediasite/Play/9a418ada639d4413865804ed4ec54fe11d
Vinicio de Jesus Perez, M.D.
Stanford University Medical Center
Inappropriate Angiogenesis in Pulmonary Arterial Hypertension: The Role of Pericytes
September 23, 2020
E
Patrick Ellinor, M.D., Ph.D.
Massachusetts General Hospital
Atrial Fibrillation from Genetics to Mechanisms
March 6, 2019
John Elrod, Ph.D.
Lewis Katz School of Medicine at Temple University
Mitochondrial Calcium Signaling in Cardiac Physiology and Disease
February 7, 2018
F
Jason Fish, Ph.D.
University Toronto
Decoding the Non-coding Regulatory Pathways of Vascular Inflammation
October 3, 2018
Mark Fishman, M.D.
Massachusetts General Hospital
Genetic Architecture of Social Behavior in Zebrafish
May 9, 2018
Garret FitzGerald, M.D.
Perelman School of Medicine
Cardiovascular Hazard and NSAIDs
November 1, 2017
David Frank, M.D., Ph.D.
Children's Hospital of Philadelphia
Defining Mechanisms of Cardiopulmonary Cell Fate for Pediatric Pulmonary Hypertension Therapy
December 20, 2017
Sarah Franklin, Ph.D.
University of Utah School of Medicine
The Lysine Methyltransferase Smyd1 Regulates Growth and Metabolism in the Heart
September 25, 2019
G
Anna Gelzer D.V.M., Ph.D.
School of Veterinary School of Medicine
Spontaneous Models of Arrhythmogenic, Cardiomyopathic, and Valvular Disease
February 12, 2020
Guillermo Garcia-Cardena, Ph.D.
Brigham and Women’s Hospital, Boston
Novel Drivers of Endothelial Cell Dysfunction
April 10, 2019
Brian Glancy, Ph.D.
NHLBI
The Muscle Mitochondrial Reticulum
May 2, 2018
David Glass, M.D.
Regeneron Pharmaceuticals, Inc. & Harvard Medical School
Molecular Mechanisms of Aging, Including in Skeletal Muscle
January 15, 2020
Ira Goldberg, M.D.
New York University Langone Health
Feeding the Heart with Fat
October 30, 2019
Marcus Goncalves, M.D., Ph.D.
Cornell University
Developing Precision Nutrition for Cancer
December, 2, 2020
RECORDING: https://mediasite.med.upenn.edu/mediasite/Play/713fe65dcdf148308aa41e64d7088da21d
Robert Gorman, M.D.
Perelman School of Medicine
Post-MI LV Remodeling: An Engineering Perspective with Implications for Regenerative Therapies
January 24, 2018
Daniel Greif, M.D.
Yale University School of Medicine
Vascular Mural Cells in Development and Disease
May 1, 2019
Courtney Griffin, Ph.D.
University of Oklahoma Health Sciences Center
Exploiting Chromatin-Remodeling Complexes to Study Vascular Development and Maintenance
May 15, 2019
Asa Gustafsson, Ph.D.
Skaggs School of Pharmacy and Pharmaceutical Sciences
Novel Mechanisms of Mitochondrial Quality Control in the Heart
December 19, 2018
H
Timothy Hla, Ph.D.
Boston Children's Hospital
Novel Insights into Endothelial GPCR Regulation of Transcriptional Mechanisms of Angiogenesis and Organotypic Specialization
February 5, 2020
Priscilla Hsue, M.D.
UCSF School of Medicine
HIV Infection, Inflammation and Cardiovascular Disease: 2018 Update
December 5, 2018
I
Erik Ingelsson M.D., Ph.D., F.A.H.A.
Stanford University
Ten Years and Hundreds of Novel Cardiovascular Loci: What Now?
May 16, 2018
J
Rajan Jain, M.D.
Perelman School of Medicine
Understanding How Genome Organization Regulates Cardiac Development and Disease
February 6, 2019
K
Mark Kahn, M.D.
Perelman School of Medicine
Valve Hemodynamics in Development and Disease
January 17, 2018
David Kass, M.D.
John Hopkins University School of Medicine
How PKG Regulates Protein Quality Control
December 4, 2019
Daniel Kelly, M.D.
Perelman School of Medicine
Fuel Metabolic Checkpoints as Targets for Cardiovascular Disease
October 4, 2017
Richard Kitsis, M.D.
Albert Einstein College of Medicine
Chemical and Structural Approaches to Manipulating Cell Death
November 7, 2018
Marc Kraus, D.V.M.
School of Veterinary School of Medicine
Spontaneous Models of Arrhythmogenic, Cardiomyopathic, and Valvular Disease
February 12, 2020
Calvin Kuo, M.D., Ph.D.
Stanford University School of Medicine
Molecular Regulation of the Blood-Brain Barrier
April 4, 2018
L
Kory Lavine, M.D., Ph.D.
Washington University School of Medicine in St. Louis
Leveraging Immune Cell Diversity in the Failing Heart
October 23, 2019
Mitchell Lazar, M.D., Ph.D.
Perelman School of Medicine
Transcriptional Regulation of Metabolism
November 29, 2017
Nicholas Leeper, M.D.
Stanford University School of Medicine
The Role of Efferocytosis in Cardiovascular Disease
September 19, 2018
Leslie Leinwand, Ph.D.
Colorado University Denver School of Medicine
Myosin Myopathies: Pathogenesis and Therapeutic Potential
October 7, 2020
Merry Lindsey, Ph.D.
University of Mississippi
Cardiac Remodeling After Myocardial Infarction
October 2, 2019
M
Andy Marks, M.D.
Columbia University
What Makes the Heart Pump: High Resolution Structure and Function of the Ryanodine Receptor
October 18, 2017
James Martin, M.D., Ph.D.
Baylor College of Medicine
Hippo Signaling in Heart Regeneration
January 10, 2018
Megan McCain, Ph.D.
University of Southern California
Engineering "Heart on a Chip" Platforms for Cardiac Disease Modeling
March 13, 2019
Tim McKinsey, Ph.D.
University of Colorado Denver - Anschutz Medical Campus
Protein Acetylation in Heart Failure: The Epigenome and Beyond
April 11, 2018
Jeffery Molkentin, Ph.D.
Cincinnati Children’s Hospital Medical Center
An Acute Immune Response Underlies the Benefit of Cardiac Adult Stem Cell Therapy
April 3, 2019
Edward Morrisey, Ph.D.
Perelman School of Medicine
Ensuring the Cardiovascular System Has Something to Work With: Building and Rebuilding the Lungs
March 20, 2019
Deborah Muoio, Ph.D.
Duke University Medical Center
Integrating Molecular Phenomics and Respiratory Fluxomics to Decipher the Metabolic Basis of Heart Failure
October 24, 2018
Elizabeth Murphy, Ph.D.
NHLBI
Cell Death in Cardiac Ischemia and Reperfusion: The Role of Mitochondrial Ca2+ and the Mitochondrial Permeability Transition Pore
October 14, 2020
Kiran Musunuru, M.D., Ph.D.
Perelman School of Medicine
Discovery and Therapeutic Genome Editing of Coronary Heart Disease Genes
December 6, 2017
Diagnosis, Prevention, and Treatment of Cardiovascular Diseases with Genome Editing
September 16, 2020
N
Matthias Nahrendorf, M.D., Ph.D.
Massachusetts General Hospital
Innate Immunity and Cardiovascular Health
October 16, 2019
Stefania Nicoli, Ph.D.
Yale School of Medicine
RNA Mechanisms Governing Endothelial Cell Behaviors in Development and Homeostasis
January 22, 2020
O
Mark Oyama, D.V.M., M.S.C.E.
School of Veterinary School of Medicine
Spontaneous Models of Arrhythmogenic, Cardiomyopathic, and Valvular Disease
February 12, 2020
P
Kit Parker, Ph.D.
Harvard University
Designing, Building, and Testing Muscular Pumps
February 20, 2019
Liming Pei, Ph.D.
Perelman School of Medicine
Listen to your Heart
December 13, 2017
Jorge Plutzky, M.D.
Harvard Medical School
Joint IDOM/CVI Seminar
May 22, 2019
Michael Potente, M.D.
Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
Metabolic Regulation of Endothelial Growth State
October 9, 2019
Benjamin Prosser, Ph.D.
Perelman School of Medicine
Cardiomyocyte Mechanobiology in Health and Heart Failure
September 26, 2018
William Pu, M.D.
Harvard Medical school & Boston Children's Hospital
From Engineered Tissue Models to Gene Therapy for Inherited Heart Disease
October 28, 2020
Q
R
Daniel Rader, M.D.
Perelman School of Medicine
New Biology in Cardiometabolic Traits Revealed Through Human Genetics
November 8, 2017
Kristy Red-Horse, Ph.D.
Stanford University
Building and Rebuilding the Heart: Coronary Artery Development and Regeneration
January 23, 2019
Howard Rockman, M.D.
Duke University School of Medicine
Biased G Protein-Coupled Receptor Signaling
March 27, 2019
S
Michael Sacks, Ph.D.
The University of Texas at Austin
Multi-Resolution Models of the Mitral Heart Valve: From Mechanobiology to Surgical Repair
October 31, 2018
Vijay Sankaran, M.D., Ph.D.
Broad Institute of MIT and Harvard
Genetic Studies of Human Hematopoiesis
November 28, 2018
Arndt Siekmann, Ph.D.
Perelman School of Medicine
Branching Morphogenesis: The Many Ways to Grow a Tree
November 18, 2020
Sydney Shaffer, M.D., Ph.D.
Perelman School of Medicine
Making Sense of Transcriptional Heterogeneity in Rare Cells
February 19, 2020
Shey-Shing Sheu, Ph.D., F.A.H.A.
Thomas Jefferson University
Defeating Heart Failure with Energy: Mechanisms of Cardiac Excitation-Contraction-Energetics Coupling
October 10, 2018
Raymond Soccio, M.D., Ph.D.
Perelman School of Medicine
Genetics of Gene Regulation by PPAR Nuclear Receptors in Cardiometabolic Disease
May 23, 2018
Didier Stainier, Ph.D.
Max Planck Institute for Heart and Lung Research
Biological Robustness: Genetic Compensation and Transcriptional Adaptation
February 26, 2020
Matthew Steinhauser, M.D.
Brigham and Women’s Hospital, Division of Cardiovascular Medicine
White Adipose Plasticity and Systemic Insulin Resistance
November 13, 2019
Katalin Susztak, M.D., Ph.D.
Perelman School of Medicine
APOL1: The Balance Imposed by Infection, Selection, Kidney and Cardiovascular Disease
May 8, 2019
T
Ira Tabas, M.D., Ph.D.
Columbia University Irving Medical Center
Macrophage Metabolism in Atherosclerosis
September 3, 2019
Alan Tall, M.D.
Columbia University
Lipids, Hematopoiesis and Athero-Thrombosis
February 14, 2018
Rong Tian, M.D., Ph.D.
University of Washington
Is Metabolism a Driver in Pathological Remodeling of the Heart?
March 7, 2018
U
V
Benjamin Voight, Ph.D.
Perelman School of Medicine
One Shot, One Opportunity: Making it Count with Computational Human Genomics
October 25, 2017
Tom Vondriska, Ph.D.
UCLA
Epigenomics of Cardiovascular Disease
April 24, 2019
W
Douglas Wallace, Ph.D.
Hospital of the University of Pennsylvania
A Mitochondrial Etiology of Complex Diseases
October 11, 2017
Kenneth Walsh, Ph.D.
Boston University School of Medicine
Somatic Mutations, Clonal Hematopoiesis and Cardio-metabolic Risk
Jamuary 3, 2018
Yibin Wang, Ph.D.
UCLA David Geffen School of Medicine
Common Pathway in Cardiometabolic Regulation: Signaling Beyond Bioenergetics
April 25, 2018
Hao Wu, Ph.D.
Perelman School of Medicine
Decoding Human Ventricular Cardiomyocyte Specification and Maturation with Integrated Cell-Type Specific Epigenomic and Transcriptomic Analysis
October 17, 2018
Joshua Wythe, Ph.D.
Baylor College of Medicine
Somatic KRAS Gain of Function in Sporadic Brain Arteriovenous Malformations
September 30, 2020
X
Y
Martin Young, Ph.D.
The University of Alabama at Birmingham
Circadian Regulation of Cardiac Processes: Physiologic Importance and Pathologic Implications
November 4, 2020
RECORDING: https://mediasite.med.upenn.edu/mediasite/Play/3df03f6917d641db85da7f56234e0ae11d
Z
TRIPS Series (Trainee Research in Progress Seminar Series)
All CVI TRIPS Seminars for Spring 2021 will be held at 12:00 PM virtually via BlueJeans. Click the link below to enter the event:
https://bluejeans.com/741347201
January 12, 2021
Haig Aghajanian, PhD, Postdoctoral Associate
Epstein Lab
"CAR T Cell Immunotherapy for the Treatment of Heart Disease"
Caitlyn Bowman, PhD, Postdoctoral Fellow
Arany Lab
"Quantitative Analysis of Macronutrient Consumption in Late-Gestation Pregnant Mice: Implications for Fetal Metabolism"
February 9, 2021
Timothy Matsuura, PhD, Postdoctoral Associate
Kelly Lab
"Targeting Ketone Metabolism as a Novel Heart Failure Therapy"
Senthil Selvaraj, MD, Postdoctoral Associate
Bravo Lab
"Ketogenic Diet Versus Exogenous Ketones on Myocardial Glucose Suppression using FDG-PET: Findings from KEETO-CROSS"
March 9, 2021
Derek Sung, BS, Graduate Student
Kahn Lab
"VEGF-C/VEGFR3 Governs VE-Cadherin Dynamics During Sinusoidal Angiogenesis and Lymphangiogenesis"
Yuanjun Guo, PhD, Postdoctoral Associate
Kelly Lab
"Defining the Protein Interactome of Estrogen-Related Receptors"
April 13, 2021
Norrisa Haynes, MD, MPH, Postdoctoral Fellow
Groeneveld Lab
"Preparing for the 3rd and 4th Waves of COVID-19"
Timothy Luongo, PhD, Postdoctoral Fellow
Baur Lab
"Defining the Physiological Function and Molecular Regulation of Mitochondrial NAD+ Transport"
May 11, 2021
Derek Liberti, BA, Graduate Student
Morrisey Lab
"Alveolar Epithelial Fate Decisions Drive Lung Regeneration"
Bailey Koch, PhD, Postdoctoral Fellow
Jain Lab
"Nuclear Architecture: Establishment and Maintenance Throughout the Cell Cycle"
June 8, 2021
William Patrick, MD, Postdoctoral Fellow
Desai / Groeneveld Lab
"Improving Implementation In Cardiovascular Medicine"
Kwaku Quansak, BA, Graduate Student
Frank Lab
"The Epigenetic and Transcriptional Regulator BRD4 Promotes Lung Epithelial Cell Fate and Growth "
Workshops
Hosted by Dr. Kiran Musunuru
Note: All workshops are RSVP REGISTRATION ONLY as seats are limited. Contact Emily Schuster (emily.schuster@pennmedicine.upenn.edu) for more information.
Tuesday, November 27, 2018 12pm, Smilow 11-146AB
CRISPR-Cas9 Genome Editing Bootcamp (Advanced Level)
Dr. Kiran Musunuru
Genome-editing tools, particularly CRISPR-Cas9, are transforming biomedical investigation. This practical, hands-on workshop, organized by the CVI Genetic and Epigenetic Origins of Disease (GEODe) Program, is intended for anybody interested in learning how to use CRISPR-Cas9-based technologies. The advanced-level workshop will follow a flipped-classroom, active-learning model. Participants will review an online video/slides before the meeting. In the workshop, participants will work in teams on virtual experiments in which base editing, epigenome editing, and other advanced concepts are explored (requiring participants to bring their own WiFi-capable laptops).
Tuesday, September 18, 2018 12pm, Smilow 11-146AB
CRISPR-Cas9 Genome Editing Bootcamp (Basic Level)
Dr. Kiran Musunuru
Genome-editing tools, particularly CRISPR-Cas9, are transforming biomedical investigation. This practical, hands-on workshop, organized by the CVI Genetic and Epigenetic Origins of Disease (GEODe) Program, is intended for anybody interested in learning how to use CRISPR-Cas9-based technologies. The basic-level workshop will follow a flipped-classroom, active-learning model. Participants will review an online video/slides before the meeting. In the workshop, participants will work in teams on virtual experiments in which knockout/knock-in mice and cell lines are generated (requiring participants to bring their own WiFi-capable laptops). Participants will learn online tools to design CRISPR-Cas9 reagents, common pitfalls to avoid, and interpreting data from genome-editing experiments.
Monday, May 14, 2018 12pm, Smilow 11-146AB
CRISPR-Cas9 Genome Editing Bootcamp (Advanced Level)
Dr. Kiran Musunuru
Genome-editing tools, particularly CRISPR-Cas9, are transforming biomedical investigation. This practical, hands-on workshop, organized by the CVI Genetic and Epigenetic Origins of Disease (GEODe) Program, is intended for anybody interested in learning how to use CRISPR-Cas9-based technologies. The advanced-level workshop will follow a flipped-classroom, active-learning model. Participants will review an online video/slides before the meeting. In the workshop, participants will work in teams on virtual experiments in which base editing, epigenome editing, and other advanced concepts are explored (requiring participants to bring their own WiFi-capable laptops).
Tuesday, January 23, 2018 12pm, Smilow 11-146AB
CRISPR-Cas9 Genome Editing Bootcamp (Basic Level)
Dr. Kiran Musunuru
Genome-editing tools, particularly CRISPR-Cas9, are transforming biomedical investigation. This practical, hands-on workshop, organized by the CVI Genetic and Epigenetic Origins of Disease (GEODe) Program, is intended for anybody interested in learning how to use CRISPR-Cas9-based technologies. The basic-level workshop will follow a flipped-classroom, active-learning model. Participants will review an online video/slides before the meeting. In the workshop, participants will work in teams on virtual experiments in which knockout/knock-in mice and cell lines are generated (requiring participants to bring their own WiFi-capable laptops). Participants will learn online tools to design CRISPR-Cas9 reagents, common pitfalls to avoid, and interpreting data from genome-editing experiments.
CV Grand Rounds
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