Career Opportunities
Positions: 1 postdoctoral researcher. 2 PhD Studentships (including stipend and fees)
Project Description:
A fundamental limitation with current approaches aiming to bioprint tissues and organs is an inability to generate constructs with truly biomimetic composition and structure, resulting in the development of engineered tissues that cannot execute their specific function in vivo. This is perhaps unsurprising, as many tissues and organs continue to mature postnatally, often taking many years to attain the compositional and structural complexity that is integral to their function. A potential solution to this challenge is to engineer tissues that are more representative of an earlier stage of development, using bioprinting to not only generate such constructs, but to also provide them with guiding structures and biochemical cues that supports their maturation into fully functional tissues or organs within damaged or diseased in vivo environments. It has recently been demonstrated that such developmental processes are better recapitulated in ‘microtissues’ or ‘organoids’ formed from self-organizing (multi)cellular aggregates, motivating their use as biological building blocks for the engineering of larger scale tissues and organs. The main goal of this project is to develop a new bioprinting platform capable of spatially patterning numerous cellular aggregates or microtissues into scaled-up, personalised durable load-bearing grafts and guiding their (re)modelling into fully functional tissues in vivo within damaged or diseased environments. This will be achieved using a converged bioprinting approach capable of rapidly depositing cells and microtissues into guiding scaffold structures with high spatial resolution in a rapid, reliable, reproducible and quantifiable manner. These guiding structures will then function to direction the fusion and remodelling of cellular aggregates and microtissues into structurally organised tissues in vitro and in vivo, as well as providing medium-term (3-5 years) mechanical support to the regenerating tissue. The successful applicants will join a large consortium, working with academic and industrial partners from across Europe and New Zealand to address the goals of the project.
For more information about the individual PhD and postdoctoral positions, please contact Prof. Daniel Kelly (kellyd9@tcd.ie).
Applicant criteria:
Postdoctoral researcher: The ideal applicant will have a PhD in biomedical engineering, biomaterials, tissue engineering or a related discipline. Previous experience in 3D (bio)printing, hydrogels, tissue engineering, cell culture, gene expression, biochemical analysis, mechanical testing, histology techniques, immunomodulatory behaviour would be highly advantageous. Excellent written and oral communication skills are essential.
PhD studentships: Degree in Biomedical Engineering, Mechanical Engineering, Biomedical Sciences or a related discipline. Previous experience in biomaterials, tissue engineering, 3D (bio)printing, cell culture and/or biomechanical testing would be desirable.
Start Date: From December 2024 onwards; positions will remain open until they are filled.
The Kelly Lab: Dr Daniel Kelly is the Professor of Tissue Engineering at Trinity College Dublin. He is also the co-lead of the ‘Materials for Health’ platform in AMBER, the Science Foundation Ireland funded materials science centre based in Trinity College Dublin. He is a past recipient of a Science Foundation Ireland President of Ireland Young Researcher Award, a Fulbright Visiting Scholar grant (at the Department of Biomedical Engineering in Columbia University, New York) and five European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept 2017, 2023; Advanced grant 2021). His lab focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. The successful applicant will join a dynamic, multidisciplinary lab consisting of 15 postdoctoral researchers and PhD students based in the Trinity Centre for Biomedical Engineering. More information can be found here: https://www.kelly-lab.com/
How to apply: CVs with the names and contact details of three referees should be submitted via email to Prof. Daniel Kelly (kellyd9@tcd.ie).
About the Advanced Materials and Bioengineering Research Centre (AMBER): AMBER is a Science Foundation Ireland funded centre that provides a partnership between leading researchers in materials science and industry. More information can be found at http://ambercentre.ie/
The AMBER research centre, as a community of researchers, welcomes its responsibility to provide equal opportunities for all. We are actively seeking diversity in our research teams and particularly encourage applications from underrepresented groups.
About the Trinity Centre for Biomedical Engineering (TCBE): TCBE is a key research centre in Trinity College combining fundamental research with translation to clinical practice. TCBE provides a structure to bring bioengineers, basic scientists and clinicians together to focus on important clinical needs and has four key research themes: Medical Devices & Advanced Drug Delivery, Neural Engineering, Biomechanics & Mechanobiology, Tissue Engineering & Regenerative Medicine. The project work will be carried out in our state-of-the-art facilities located in the Trinity Biomedical Sciences Institute.
Posted 9/13/24
Candidates must have a Ph.D. or M.D degree, a history of high quality, impactful research, federal funding, peer reviewed publications, and evidence of collaboration. Ideal candidates are expected to be currently funded by the NIH, NSF, VA or DoD. Expected rank for this position will be Assistant Professor, however, final rank and tenure status will be commensurate with selected candidate’s experience.
For immediate consideration, please send a cover letter and a recent CV, including names and contact information of three references to this posting.
Posted 9/5/24
Applications are invited for a postdoctoral associate position investigating chondrocyte response to impact injury in a collaborative project between the Meinig School of Biomedical Engineering, the Department of Physics, and the College of Veterinary Medicine and at Cornell University in Ithaca, NY. The position will act as a bridge the laboratories of Prof. Larry Bonassar, Prof. Itai Cohen, and Dr. Michelle Delco. Our research focuses on understanding the relationship between calcium signaling, mitochondrial polarization, apoptosis, and cell death in cartilage after impact injury using cutting edge techniques in chondrocyte biology, biomechanics, imaging, and machine learning. The project will investigate mechanisms of cartilage mechanotransduction with the goal of identifying avenues of therapies for posttraumatic osteoarthritis. The position is anticipated for 2 years with salary commensurate with experience.
Applicants should have a PhD in Biomedical Engineering, Biomedical Sciences, Physics or a related field. Of particular interest are candidates with experience in cartilage biology, biomechechanics, mechanobiology, or machine learning.
Interested parties should respond by including a CV and a list of three references via email to Prof. Larry Bonassar (ljb244@gmail.com), Prof, Itai Cohen (itai.cohen@cornell.edu), and Dr. Michelle Delco (mld12@cornell.edu).
Posted 7/2/24
The Department of Orthopaedic Surgery at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for an Assistant Professor position in the tenure track. Applicants must have an M.D. or Ph.D. or M.D./Ph.D. degree and have demonstrated excellent qualifications in education and research.
Teaching responsibilities may include teaching students, residents and research assistants.
Research responsibilities may include developing an independent, extramurally-funded research program, as well as collaborating with other research and clinical faculty in the Department of Orthopaedic Surgery, across the Penn Center for Musculoskeletal Disorders and elsewhere in the Penn community.
The successful applicant will have experience in an identified area of musculoskeletal research such as (but not limited to) orthopaedic biomechanics at the organismal and/or tissue level, soft tissue bioengineering, developmental biology, musculoskeletal molecular and/or stem cell biology, wound repair and inflammation, or drug discovery and molecular biophysics as it applies to the musculoskeletal system.
Applications should include a cover letter, the applicant’s CV, a Research Statement (limited to two pages) and an Education and Mentoring statement (limited to one page). Please direct all inquiries to the Search Committee Co-Chairs, Drs. Joel Boerckel (boerckel@pennmedicine.upenn.edu) and Sherry Liu (xiaoweil@pennmedicine.upenn.edu), Co-Directors of the McKay Orthopaedic Research Laboratory. Applicants must apply online by October 31st, 2024.
We seek candidates who embrace and reflect diversity in the broadest sense. The University of Pennsylvania is an EOE. Minorities/Women/Individuals with disabilities/Protected Veterans are encouraged to apply.
Posted 6/3/24
This is a new postbacc program developed by the University of Florida Department of Neuroscience, that aims to develop a strong research and clinical workforce that will be dedicated to research and treatment of cognitive aging and Alzheimer’s disease and related dementias (ADRD).
The GATORAADE program offers the following:
- $30K annual stipend for up to two years
- Placement as a full-time research assistant in the lab of a UF research mentor that aligns with the applicant’s interests and professional goals.
- Tailored mentoring committee formed by three members: the trainee’s research mentor, a near-peer mentor (UF Neuroscience PhD student), and a GATORAADE advisory committee faculty member.
- Opportunity to boost the applicant’s GPA by completing our 12-credit online graduate certificate in Neuroscience program, which offers didactic instruction in foundational knowledge of aging and ADRD mechanisms.
- Funding in support of professional development activities that extend the trainee’s knowledge in brain aging and ADRDs.
If you are interested in applying, please use the link below to get more information and access the application portal. The deadline to submit your application is May 31, 2024, and the expected start of the program will be Fall semester 2024 (August).
Please reach out to me or Mrs. Katie McIntyre (kathleenmcintyre@phhp.ufl.edu) if you have any questions.
Posted 5/2/24
Assistant Professor of Large Animal Surgery, Charles W. Raker Endowed Chair of Orthopedic Surgery
Dr. Stewart can be reached directly through email (hstew@upenn.edu) or phone (610-925-6132).
Research Laboratory Manager
A full-time Research Laboratory Manager position at the University of Pennsylvania’s New Bolton Center is available in the Stewart laboratory in the Department of Clinical Studies. This position is currently approved for 5 years, with continuation contingent on funding. The primary role of this position is to help establish this new orthopedic laboratory focused on translational osteoarthritis research
Posted 4/22/24
Research Technician
The primary role of the position is to work in an orthopedic laboratory focused on translational bone research for the treatment of musculoskeletal diseases, using a variety of different veterinary species and occasional human samples. Position is located at New Bolton Center, Kennett Square, Pa.
Posted 4/22/24