Gullbrand Laboratory

Welcome to Gullbrand Laboratory

The Gullbrand Lab studies how aberrant structure-function relationships across the spine contribute to the initiation and progression of degenerative disc disease. Our work spans multiple length scales across model systems of disease and human tissue. We probe spinal tissues by employing a suite of biomechanical and bioimaging tools, elucidating connections between tissue structure and degeneration of intervertebral discs, vertebral bones, cartilage endplates, and facet joints. Our group also focuses on utilizing this knowledge to inform the development of tissue-engineering-based approaches for disc regeneration. Central to this work, in collaboration with Harvey Smith, MD and Robert Mauck, PhD, is the translation of a whole tissue engineered intervertebral disc replacement towards clinical application in human patients. 

The Gullbrand lab is uniquely situated in the Translational Musculoskeletal Research Center at the Philadelphia Corporal Michael J. Crescenz VA Medical Center.

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Congratulations to Dr. Sachin Gupta and Coauthors
July 11, 2022
Congratulations to Dr. Sachin Gupta and coauthors for the paper "Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration" published in the Journal of Orthopaedic Research!

Matthew Attends New Harvest 2022
June 09, 2022
Research Engineer Matthew Fainor attended the 2022 New Harvest Conference on Cellular Agriculture where he spent two days connecting with experts in the field looking to scale tissue engineering technology for applications in our food system.

Emory Musculoskeletal Research Center Invites Dr. Gullbrand to Speak
April 26, 2022
Dr. Gullbrand spoke about the lab's work on "Tissue Crosstalk in Intervertebral Disc Degeneration and Repair" with members of the Emory Musculoskeletal Research Center.

Gullbrand Lab Presents at ORS 2022!
February 05, 2022
Congratulations to members of the Gullbrand-Mauck Spine group on their presentations at ORS 2022! Dr. Sarah E. Gullbrand, Ana P. Peredo, Lance Murphy, and Matthew Fainor presented five projects investigating the osteogenic effects of novel biomaterials, the mediation of neuroinflammatiory molecules in intervertebral disc injury, the degenerative cross-talk between intervertebral discs and facets, and the translational impact of annular repair and replacement disc devices as tested in goat models.

Dr. Sarah Gullbrand Receives JOR Spine Early Career Award
January 14, 2022
Congratulations to Dr. Sarah Gullbrand for receiving the 2022 JOR Spine Early Career Award! This award recognizes the ‘rising stars’ of the spine field and highlights their outstanding work published in the JOR Spine.

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