Mauck Laboratory

Welcome to Mauck Laboratory

The goals of our research program in soft tissue mechanobiology and tissue engineering are to understand the physiologic and patho-physiologic processes that regulate the formation, maturation, and adult function of soft connective tissues.  We believe that such an understanding will better direct our efforts to generate functional tissue replacements with a particular focus on articular cartilage and the knee meniscus. Our program utilizes various mechanical and biological testing modalities, scaffold fabrication techniques, and bioreactor culture conditions to explore these issues in both animal and human model systems. Specific information about current work in the Mauck Lab can be found by visiting the Ongoing Research Projects page.

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What's New

Congratulations to Esteban D. Ongini and Coauthors on JOR Spine Publication
February 06, 2025
Congratulations to Esteban D. Ongini and coauthors on their JOR Spine publication entitled "Annulus Fibrosus Repair via Interpenetration of a Non-Woven Scaffold Supports Tissue Integration and Prevents Re-Herniation." This latest publication is part of our collaborative work with the Zürich-based medical device company ZuriMED Technologies and the Snedeker Lab using their proprietary fiberlocking device for AF repair.

Emily Sharp Wins 2025 ORS Dr. Peter Roughley Award
December 10, 2024
Congratulations to PhD student Emily Sharp for earning the 2025 Orthopaedic Research Society Dr. Peter Roughley Award. Awarded by the ORS Spine Section, the Dr. Peter Roughley Award recognizes outstanding work in spine, disc, and cartilage biology and provides support for a mentor/trainee research collaboration. Under the mentorship of Dr. Sibylle Grad, Emily will use her award to travel to the AO Research Institute in Davos, Switzerland, utilizing their innovative six degree-of-freedom bioreactor to better understand how multi-functional biomaterials may heal or fail disc herniation patients.

Congratulations to Dakota and Coauthors
May 22, 2024
Congratulations to Dakota on his first postdoc project, "Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and Taz," now posted on PNASNews

Congratulations to Dr. Sarah Gullbrand and Coauthors on European Cells and Materials Publication
April 23, 2024
Congratulations to Dr. Gullbrand and coauthors on their publication in European Cells and Materials. The study, entitled "Intervertebral Disc Degeneration Instigates Vertebral Endplate Remodeling and Facet Joint Pathology in a Large Animal Model," characterizes the degenerative changes that occur across all substructures of the spine following induction of intervertebral disc degeneration in an initially healthy spine using chondroitinase ABC.

Congratulations to Grey and Coauthors
April 19, 2024
Congrats to Grey and Coauthors on their latest publication, "Microenvironmental mechanoactivation through Yap/Taz suppresses chondrogenic gene expression," now posted online in the Molecular Biology of the Cell

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