Dodge Laboratory

Mieke Sinnesael

Post-Doctoral Fellow

University of Pennsylvania

Hometown

Brussels, Belgium

Education

Ph.D. Biomedical Sciences, KU Leuven, Leuven, Belgium M.S. Biomedical Sciences Ugent, Ghent, Belgium B.S. Biomedical Sciences, VUB, Brussels , Belgium

Areas of Special Interest

During my Ph.D, my research was focused on the maintenance of the male musculosketal system and the role of androgens and mechanical loading. Now my research is focused on developing a high throughput system to allow screening of potential therapeutics that can alter the development of osteoarthritis after trauma.

Awards

2012, BES Young Investigator Award, 22nd meeting of the belgian endocrine society, Luik, Belgium

2012, ECTS New Investigator Award, 39th European symposium on calcifies tissues, Stockholm, Sweden

Publications

"The androgen receptor has no direct antiresorptive actions in mouse osteoclasts", Molecular and Cellular Endocrinology (2015), Mieke Sinnesael, Ferran Jardi, Ludo Deboel, Michal R Laurent, Vanessa Dubois, Jeffrey D Zajac, Rachel A Davey, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren

"Androgens inhibit the osteogenic response to mechanical loading in adult male mice", Endocrinology (2015), Mieke Sinnesael, Michal R Laurent, Ferran Jardi, Vanessa Dubois, Ludo Deboel, Peter Delisser, Behets GJ, D'Haese PC, Geert Carmeliet, Frank Claessens, Dirk Vanderschueren

"A satellite cell-specific knockout of the androgen receptor reveals myostatin as a direct androgen target in skeletal muscle", FASEB Journal (2014), Vanessa Dubois, Michal R Laurent, Mieke Sinnesael, Nele Cielen, Christine Helsen, Liesbeth Clinck- emalie, Liens Spans, Ghislaine Gayan-Ramirez, Louise Deldique, Peter Hespel, Geert Carmeliet, Dirk Vanderschueren, Frank Claessens

"Androgens and estrogens in skeletal sexual dimorphism", Asian Journal of Andrology (2014), Michal R Laurent, Leen Antonio, Mieke Sinnesael, Vanessa Dubois, Evelien Gielen, Frank Claessens, Dirk Vanderschuere

"Novel insights in the regulation and mechanism of androgen action on bone", Current Opinion in Endocrinology Diabetes and Obesity (2013), Mieke Sinnesael, Frank Claessens, Steven Boonen, Dirk Vanderschueren

"Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes", Journal of Bone and Mineral Research (2012), Mieke Sinnesael, Frank Claessens, Michal R Laurent, Vanessa Dubois, Steven Boonen, Ludo Deboel, Dirk Vanderschueren"Notch induces human T-cell receptor gd+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway", Leukemia (2011), Stefanie Van Coppernolle, Stijn Vanhee, Greet Verstichel, Sylvia Snauwaert, A van der Spek, Imke Velghe, Mieke Sinnesael, MH Heemskerk, T Taghon, George Leclercq, Jean Plum, AW Langerak, Tessa Kerre, Bart Vandekerckhove

"Testosterone and the male skeleton: a dual mode of action", Journal of Osteoporosis (2011), Mieke Sinnesael, Steven Boonen, Frank Claessens, Evelien Gielen, Dirk Vanderschueren

"Calcium and vitamin D supplementation in men", Journal of Osteoporosis (2011), Evelien Gielen, Steven Boonen, Dirk Vanderschueren, Mieke Sinnesael, Annemieke Verstuyf, Frank Claessens, Koen Milisen, Sabine Verschueren

"7α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: a preclinical study in the aged male orchidectomized rat model", International Journal of Andrology (2011), Mieke Sinnesael, Filip Callewaert, Maarten Moreels, Nardender Kumar, Regine Sitruk-Wrae, Karen Van Proeyen, Peter Hespel, Steven Boonen, Frank Claessens, Dirk Vanderschueren

"Skeletal sexual dimorphism: relative contribution of sex steroids, GH-IGF1, and mechanical loading", Journal of Endocrinology (2010), Filip Callewaert, Mieke Sinnesael, Evelien Gielen, Steven Boonen, Dirk Vanderschueren

Book Chapters

Vanderschueren D, Sinnesael M, Gielen E, Claessens F and Boonen S, 2012 Testotsreone and bone. In Nieschlag E & Behre H (Eds.), Testosterone: action, deficiency, substitution. (pp 177-190). New York, United States: Cambridge University Press

Abstracts

2012, ECTS, poster and presentation: "Targeted disruption of androgen receptor (AR) in male mouse osteocytes: the androgen receptor in osteocytes is important for the maintenance of male skeletal integrity”, Mieke Sinnesael, Frank Claessens, Michal R Laurent, Vanessa Dubois, Steven Boonen, Ludo Deboel, Dirk Vanderschueren

2012, BES, poster and presentation: "Targeted disruption of androgen receptor (AR) in male mouse osteocytes: the androgen receptor in osteocytes is important for the maintenance of male skeletal integrity”, Mieke Sinnesael, Frank Claessens, Michal R Laurent, Vanessa Dubois, Steven Boonen, Ludo Deboel, Dirk Vanderschueren

Back to Top