Soslowsky Laboratory

Journal Clubs

 

Date Presenter Title Citation
10/22/2021 Ryan Leiphart

The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation

Liu, Han, et al. "The Scleraxis transcription factor directly regulates multiple distinct molecular and cellular processes during early tendon cell differentiation." Frontiers in cell and developmental biology 9 (2021): 1372.
9/24/2021 Christelle Darrieutort-Laffite 

Extrinsic Macrophages Protect While Tendon Progenitors Degrade: Insights from a Tissue Engineered Model of Tendon Compartmental Crosstalk

Stauber, Tino, et al. "Extrinsic Macrophages Protect While Tendon Progenitors Degrade: Insights from a Tissue Engineered Model of Tendon Compartmental Crosstalk." Advanced Healthcare Materials (2021): 2100741.
9/3/2021 Joey Newton

Tendons exhibit greater resistance to tissue and molecular-level damage with increasing strain rate during cyclic fatigue

Zitnay, Jared L., Allen H. Lin, and Jeffrey A. Weiss. "Tendons exhibit greater resistance to tissue and molecular-level damage with increasing strain rate during cyclic fatigue." Acta Biomaterialia (2021).
7/30/2021 Courtney Nuss Enhanced Tendon-to-Bone Healing via IKKb Inhibition in a Rat Rotator Cuff Model Golman M, Li X, Skouteris D, Abraham AA, Song L, Abu-Amer Y, Thomopoulos S. Enhanced Tendon-to-Bone Healing via IKKβ Inhibition in a Rat Rotator Cuff Model. Am J Sports Med. 2021 Mar;49(3):780-789. doi: 10.1177/0363546520985203. Epub 2021 Jan 28. PMID: 33507808.
4/30/2021 Jackie Carlson Regulation of extracellular matrix assembly and structure by hybrid M1/ M2 macrophages Witherel CE, Sao K, Brisson BK, Han B, Volk SW, Petrie RJ, Han L, Spiller KL. Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages. Biomaterials. 2021 Feb;269:120667. doi: 10.1016/j.biomaterials.2021.120667. Epub 2021 Jan 7. PMID: 33450585; PMCID: PMC7870567.
3/19/2021 Biao Han

Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries

Wang T, Wagner A, Gehwolf R, Yan W, Passini FS, Thien C, Weissenbacher N, Lin Z, Lehner C, Teng H, Wittner C, Zheng Q, Dai J, Ni M, Wang A, Papadimitriou J, Leys T, Tuan RS, Senck S, Snedeker JG, Tempfer H, Jiang Q, Zheng MH, Traweger A. Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries. Sci Transl Med. 2021 Feb 24;13(582):eabe5738. doi: 10.1126/scitranslmed.abe5738. PMID: 33627488.
2/5/2021 Mike DiStefano Tensile mechanical changes in the Achilles tendon due to Insertional Achilles tendinopathy Bah I, Fernandes NRJ, Chimenti RL, Ketz J, Flemister AS, Buckley MR. Tensile mechanical changes in the Achilles tendon due to Insertional Achilles tendinopathy. J Mech Behav Biomed Mater. 2020 Dec;112:104031. doi: 10.1016/j.jmbbm.2020.104031. Epub 2020 Aug 19. PMID: 32882677; PMCID: PMC8056289.
1/8/2021 Thomas Leahy Immobilization after injury alters extracellular matrix and stem cell fate Huber AK, Patel N, Pagani CA, Marini S, Padmanabhan KR, Matera DL, Said M, Hwang C, Hsu GC, Poli AA, Strong AL, Visser ND, Greenstein JA, Nelson R, Li S, Longaker MT, Tang Y, Weiss SJ, Baker BM, James AW, Levi B. Immobilization after injury alters extracellular matrix and stem cell fate. J Clin Invest. 2020 Oct 1;130(10):5444-5460. doi: 10.1172/JCI136142. PMID: 32673290; PMCID: PMC7524473.
12/4/2020 Matthew Stein The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats Rothrauff BB, Smith CA, Ferrer GA, Novaretti JV, Pauyo T, Chao T, Hirsch D, Beaudry MF, Herbst E, Tuan RS, Debski RE, Musahl V. The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats. J Shoulder Elbow Surg. 2019 Apr;28(4):654-664. doi: 10.1016/j.jse.2018.08.044. Epub 2018 Dec 4. PMID: 30527883.
10/2/2020 Steph Weiss Elastin levels are higher in healing tendons than in intact tendons and influence tissue compliance Svärd A, Hammerman M, Eliasson P. Elastin levels are higher in healing tendons than in intact tendons and influence tissue compliance. FASEB J. 2020 Aug 14. doi: 10.1096/fj.202001255R. Epub ahead of print. PMID: 32794252.
9/18/2020 Thomas Leahy Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues Zitnay JL, Jung GS, Lin AH, Qin Z, Li Y, Yu SM, Buehler MJ, Weiss JA. Accumulation of collagen molecular unfolding is the mechanism of cyclic fatigue damage and failure in collagenous tissues. Sci Adv. 2020 Aug 28;6(35):eaba2795. doi: 10.1126/sciadv.aba2795. PMID: 32923623; PMCID: PMC7455178.
9/4/2020 Harina Raja Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading Shen H, Schwartz AG, Civitelli R, Thomopoulos S. Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading. J Bone Miner Res. 2020 Aug;35(8):1494-1503. doi: 10.1002/jbmr.4018. Epub 2020 Apr 22. PMID: 32227614.
8/7/2020 Snehal Shetye β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells Mousavizadeh R, Hojabrpour P, Eltit F, McDonald PC, Dedhar S, McCormack RG, Duronio V, Jafarnejad SM, Scott A. β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells. Sci Rep. 2020 Jul 28;10(1):12644. doi: 10.1038/s41598-020-69267-6. PMID: 32724089; PMCID: PMC7387456.
7/24/2020 Brittany Taylor MRL/MpJ tendon matrix‐derived therapeutic promotes improved healing outcomes in scar‐mediated canonical tendon healing Paredes J, Pekmezian A, Andarawis-Puri N. MRL/MpJ tendon matrix-derived therapeutic promotes improved healing outcomes in scar-mediated canonical tendon healing. J Orthop Res. 2020 May 22:10.1002/jor.24754. doi: 10.1002/jor.24754. Epub ahead of print. PMID: 32441819; PMCID: PMC7680300.
7/10/2020 Ryan Leiphart Tgfb signaling is required for tenocyte recruitment and functional neonatal tendon regeneration Kaji DA, Howell KL, Balic Z, Hubmacher D, Huang AH. Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration. Elife. 2020 Jun 5;9:e51779. doi: 10.7554/eLife.51779. PMID: 32501213; PMCID: PMC7324157.
6/19/2020 Ashley Fung Heterogeneity of proteome dynamics between connective tissue phases of adult tendon Choi H, Simpson D, Wang D, Prescott M, Pitsillides AA, Dudhia J, Clegg PD, Ping P, Thorpe CT. Heterogeneity of proteome dynamics between connective tissue phases of adult tendon. Elife. 2020 May 12;9:e55262. doi: 10.7554/eLife.55262. PMID: 32393437; PMCID: PMC7217697.
6/12/2020 Kelsey Bonilla Photobiomodulation Does Not Influence Maturation and Mildly Improves Functional Healing of Mouse Achilles Tendons Locke RC, Lemmon EA, Dudzinski E, Kopa SC, Wayne JM, Soulas JM, De Taboada L, Killian ML. Photobiomodulation does not influence maturation and mildly improves functional healing of mouse achilles tendons. J Orthop Res. 2020 Aug;38(8):1866-1875. doi: 10.1002/jor.24592. Epub 2020 Jan 28. PMID: 31965620.
6/5/2020 Joey Newton Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy Yan Y, Gomez-Lopez N, Basij M, Shahvari AV, Vadillo-Ortega F, Hernandez-Andrade E, Hassan SS, Romero R, MehrMohammadi M. Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy. Biomed Opt Express. 2019 Aug 19;10(9):4643-4655. doi: 10.1364/BOE.10.004643. PMID: 31565515; PMCID: PMC6757472.
5/15/2020 Zak Beach Increased Collagen Turnover Impairs Tendon Microstructure and Stability in Integrin α2β1-Deficient Mice Kronenberg D, Michel PA, Hochstrat E, Wei M, Brinckmann J, Müller M, Frank A, Hansen U, Eckes B, Stange R. Increased Collagen Turnover Impairs Tendon Microstructure and Stability in Integrin α2β1-Deficient Mice. Int J Mol Sci. 2020 Apr 18;21(8):2835. doi: 10.3390/ijms21082835. PMID: 32325713; PMCID: PMC7215526.
5/22/2020 Courtney Nuss Low‐Dose Administration of Dexamethasone Is Beneficial in Preventing Secondary Tendon Damage in a Stress‐Deprived Joint Injury Explant Model Connizzo BK, Grodzinsky AJ. Lose-Dose Administration of Dexamethasone Is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model. J Orthop Res. 2020 Jan;38(1):139-149. doi: 10.1002/jor.24451. Epub 2019 Sep 6. Erratum in: J Orthop Res. 2020 May;38(5):1167. PMID: 31441099; PMCID: PMC7268908.
3/27/2020 Jackie Carlson Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders Smith TTG, Barr-Gillespie AE, Klyne DM, Harris MY, Amin M, Paul RW, Cruz GE, Zhao H, Gallagher S, Barbe MF. Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders. BMC Musculoskelet Disord. 2020 Jan 30;21(1):57. doi: 10.1186/s12891-020-3085-z. PMID: 32000751; PMCID: PMC6993343.
3/6/2020 Julianne Huegel Adaptive and innate immune cell responses in tendons and lymph nodes after tendon injury and repair Noah AC, Li TM, Martinez LM, Wada S, Swanson JB, Disser NP, Sugg KB, Rodeo SA, Lu TT, Mendias CL. Adaptive and innate immune cell responses in tendons and lymph nodes after tendon injury and repair. J Appl Physiol (1985). 2020 Mar 1;128(3):473-482. doi: 10.1152/japplphysiol.00682.2019. Epub 2020 Jan 16. PMID: 31944888; PMCID: PMC7099435.
2/28/2020 Carrie Barnum Tgfb signaling is critical for maintenance of the tendon cell fate Tan GK, Pryce BA, Stabio A, Brigande JV, Wang C, Xia Z, Tufa SF, Keene DR, Schweitzer R. Tgfβ signaling is critical for maintenance of the tendon cell fate. Elife. 2020 Jan 21;9:e52695. doi: 10.7554/eLife.52695. PMID: 31961320; PMCID: PMC7025861.
1/31/2020 Steph Weiss The effect of surgery on patellar tendinopathy: Novel use of MRI questions the exploitability of the rat collagenase model to humans Dan MJ, Oliver RA, Crowley JD, Lovric V, Parr WCH, Broe D, Cross M, Walsh WR. The effect of surgery on patellar tendinopathy: Novel use of MRI questions the exploitability of the rat collagenase model to humans. Knee. 2019 Dec;26(6):1182-1191. doi: 10.1016/j.knee.2019.10.017. Epub 2019 Nov 6. PMID: 31706694.
1/3/2020 Thomas Leahy Interfascicular matrix-mediated transverse deformation and sliding of discontinuous tendon subcomponents control the viscoelasticity and failure of tendons Obuchowicz R, Ekiert M, Kohut P, Holak K, Ambrozinski L, Tomaszewski KA, Uhl T, Mlyniec A. Interfascicular matrix-mediated transverse deformation and sliding of discontinuous tendon subcomponents control the viscoelasticity and failure of tendons. J Mech Behav Biomed Mater. 2019 Sep;97:238-246. doi: 10.1016/j.jmbbm.2019.05.027. Epub 2019 May 20. PMID: 31132660.
12/20/2019 Snehal Shetye Helical fibrillar microstructure of tendon using serial block-face scanning electron microscopy and a mechanical model for interfibrillar load transfer Tarafder S, Brito JA, Minhas S, Effiong L, Thomopoulos S, Lee CH. In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells. Biofabrication. 2019 Nov 18;12(1):015008. doi: 10.1088/1758-5090/ab48ca. PMID: 31561236; PMCID: PMC6904927.
12/13/2019 Harina Raja In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells Tarafder S, Brito JA, Minhas S, Effiong L, Thomopoulos S, Lee CH. In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells. Biofabrication. 2019 Nov 18;12(1):015008. doi: 10.1088/1758-5090/ab48ca. PMID: 31561236; PMCID: PMC6904927.

11/1/2019

Stacey Marvidis Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair Shen H, Yoneda S, Abu-Amer Y, Guilak F, Gelberman RH. Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair. J Orthop Res. 2020 Jan;38(1):117-127. doi: 10.1002/jor.24406. Epub 2019 Jul 26. PMID: 31286564; PMCID: PMC6917960.
Ashley Fung A distinct transition from cell growth to physiological homeostasis in the tendon Grinstein M, Dingwall HL, O'Connor LD, Zou K, Capellini TD, Galloway JL. A distinct transition from cell growth to physiological homeostasis in the tendon. Elife. 2019 Sep 19;8:e48689. doi: 10.7554/eLife.48689. PMID: 31535975; PMCID: PMC6791717.

10/4/2019

Brittany Taylor Is a Local Administration of Parathyroid Hormone Effective to Tendon‐to‐Bone Healing in a Rat Rotator Cuff Repair Model? Yoon JP, Chung SW, Jung JW, Lee YS, Kim KI, Park GY, Kim HM, Choi JH. Is a Local Administration of Parathyroid Hormone Effective to Tendon-to-Bone Healing in a Rat Rotator Cuff Repair Model? J Orthop Res. 2020 Jan;38(1):82-91. doi: 10.1002/jor.24452. Epub 2019 Aug 29. PMID: 31441073.
Joey Newton Multi‐Scale Loading and Damage Mechanisms of Plantaris and Rat Tail Tendons Lee AH, Elliott DM. Multi-Scale Loading and Damage Mechanisms of Plantaris and Rat Tail Tendons. J Orthop Res. 2019 Aug;37(8):1827-1837. doi: 10.1002/jor.24309. Epub 2019 May 2. PMID: 30977538; PMCID: PMC6790141.

9/6/2019

Catherine Bautista Tendon tissue microdamage and the limits of intrinsic repair Stauber T, Blache U, Snedeker JG. Tendon tissue microdamage and the limits of intrinsic repair. Matrix Biol. 2020 Jan;85-86:68-79. doi: 10.1016/j.matbio.2019.07.008. Epub 2019 Jul 17. PMID: 31325483.
Ryan Leiphart FGF signaling patterns cell fate at the interface between tendon and bone Roberts RR, Bobzin L, Teng CS, Pal D, Tuzon CT, Schweitzer R, Merrill AE. FGF signaling patterns cell fate at the interface between tendon and bone. Development. 2019 Aug 2;146(15):dev170241. doi: 10.1242/dev.170241. PMID: 31320326; PMCID: PMC6703712.

5/31/2019

Courtney Nuss Post-operative Tendon Loading with Treadmill Running Delays Tendon-to-Bone Healing: Immunohistochemical Evaluation in a Murine Rotator Cuff Repair Model Wada S, Lebaschi AH, Nakagawa Y, Carballo CB, Uppstrom TJ, Cong GT, Album ZM, Hall AJ, Ying L, Deng XH, Rodeo SA. Postoperative Tendon Loading With Treadmill Running Delays Tendon-to-Bone Healing: Immunohistochemical Evaluation in a Murine Rotator Cuff Repair Model. J Orthop Res. 2019 Jul;37(7):1628-1637. doi: 10.1002/jor.24300. Epub 2019 Apr 24. PMID: 30977544.
Jackie Carlson Scleraxis lineage cells contribute to organized bridging tissue during tendon healing and identify a subpopulation of resident tendon cells Best KT, Loiselle AE. Scleraxis lineage cells contribute to organized bridging tissue during tendon healing and identify a subpopulation of resident tendon cells. FASEB J. 2019 Jul;33(7):8578-8587. doi: 10.1096/fj.201900130RR. Epub 2019 Apr 5. PMID: 30951381; PMCID: PMC6593880.

3/29/2019

Zak Beach Oral Ibuprofen interferes with cellular healing responses in a murine model of achilles tendinopathy

Bittermann A, Gao S, Rezvani S, Li J, Sikes KJ, Sandy J, Wang V, Lee S, Holmes G, Lin J, Plaas A. Oral Ibuprofen Interferes with Cellular Healing Responses in a Murine Model of Achilles Tendinopathy. J Musculoskelet Disord Treat. 2018;4(2):049. doi: 10.23937/2572-3243.1510049. Epub 2018 May 21. PMID: 30687812; PMCID: PMC6347402.

Ashley Rodriguez The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis Deymier AC, Schwartz AG, Cai Z, Daulton TL, Pasteris JD, Genin GM, Thomopoulos S. The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis. Acta Biomater. 2019 Jan 1;83:302-313. doi: 10.1016/j.actbio.2018.10.024. Epub 2018 Oct 17. PMID: 30342287; PMCID: PMC6343501.

3/1/2019

Julianne Huegel Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing Chamberlain CS, Clements AEB, Kink JA, Choi U, Baer GS, Halanski MA, Hematti P, Vanderby R. Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing. Stem Cells. 2019 May;37(5):652-662. doi: 10.1002/stem.2988. Epub 2019 Feb 22. PMID: 30720911; PMCID: PMC6850358.
Yaping Ye Duration of postoperative immobilization affects MMP activity at the healing graft-bone interface: Evaluation in a mouse ACL reconstruction model Nakagawa Y, Lebaschi AH, Wada S, Green SJE, Wang D, Album ZM, Carballo CB, Deng XH, Rodeo SA. Duration of postoperative immobilization affects MMP activity at the healing graft-bone interface: Evaluation in a mouse ACL reconstruction model. J Orthop Res. 2019 Feb;37(2):325-334. doi: 10.1002/jor.24177. Epub 2018 Dec 13. PMID: 30431170; PMCID: PMC6411439.

1/11/2019

Matt Counihan Ultrastructure of tendon rupture depends on strain rate and tendon type Chambers NC, Herod TW, Veres SP. Ultrastructure of tendon rupture depends on strain rate and tendon type. J Orthop Res. 2018 Nov;36(11):2842-2850. doi: 10.1002/jor.24067. Epub 2018 Jul 13. PMID: 29901228.
Thomas Leahy Potential strain-dependent mechanisms defining matrix alignment in healing tendons Richardson WJ, Kegerreis B, Thomopoulos S, Holmes JW. Potential strain-dependent mechanisms defining matrix alignment in healing tendons. Biomech Model Mechanobiol. 2018 Dec;17(6):1569-1580. doi: 10.1007/s10237-018-1044-5. Epub 2018 Jul 12. PMID: 30003433; PMCID: PMC6330133.

11/9/2018

Carrie Barnum Substrate fiber alignment mediates tendon cell response to inflammatory signaling Schoenenberger AD, Foolen J, Moor P, Silvan U, Snedeker JG. Substrate fiber alignment mediates tendon cell response to inflammatory signaling. Acta Biomater. 2018 Apr 15;71:306-317. doi: 10.1016/j.actbio.2018.03.004. Epub 2018 Mar 10. PMID: 29530822.
Ashley Fung Embryo movements regulate tendon mechanical property development Pan XS, Li J, Brown EB, Kuo CK. Embryo movements regulate tendon mechanical property development. Philos Trans R Soc Lond B Biol Sci. 2018 Sep 24;373(1759):20170325. doi: 10.1098/rstb.2017.0325. PMID: 30249775; PMCID: PMC6158208.
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