Leslie Raffini
Professor of Pediatrics (Hematology) at the Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Hematology
The HUB for Clinical Collaboration
3500 Civic Center Blvd
13th Floor
Philadelphia, PA 19104
Division of Hematology
The HUB for Clinical Collaboration
3500 Civic Center Blvd
13th Floor
Philadelphia, PA 19104
Office: 267 426-5029
Email:
raffini@email.chop.edu
raffini@email.chop.edu
Education:
B.S. (Molecular Biology)
University of Wisconsin, 1991.
M.D.
University of Wisconsin, 1996.
M.S.C.E (Clinical Epidemiology)
University of Pennsylvania, 2005.
Permanent linkB.S. (Molecular Biology)
University of Wisconsin, 1991.
M.D.
University of Wisconsin, 1996.
M.S.C.E (Clinical Epidemiology)
University of Pennsylvania, 2005.
Description of Research Expertise
Risk Factors for Thromboembolic Events in ChildrenDescription of Clinical Expertise
Diagnosis and Management of Thromboembolic Events in ChildrenDescription of Other Expertise
Diagnosis and Management of Bleeding Disorders in ChildrenSelected Publications
Kawtharany H, Azzam M, Alkhader A, Betensky M, Hamarsha Q, Abou Zeid HK, Mansour R, Tabak C, Patel P, Baghdadi SL, Bercovitz RS, Bhat R, Biss TT, Branchford BR, Brandão LR, Chan AK, Faustino EVS, Jaffray J, Jones SE, Kerlin BA, Kucine N, Kumar R, Male C, Pelland-Marcotte MC, Raffini L, Raulji CM, Sartain SE, Takemoto CM, Tarango C, van Ommen CH, Velez MC, Vesely SK, Wiernikowski JT, Williams S, Wilson HP, Woods G, Zia A, Monagle P, Mustafa RA.: Efficacy and Safety of Thrombolysis for Pediatric Venous Thromboembolism: A Systematic Review and Meta-analysis. Blood Adv 2025.Betensky M, Albisetti M, Biss T, Bhat RV, Brandão LR, Diacovo T, Monagle P, Raffini L, Revel-Vilk S, van Ommen CH, Whitworth H, Goldenberg NA, Male C; Antithrombotic Trials Working Party of the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis.: Systematic analysis of the design, methodology, and patient population characteristics of the pediatric direct oral anticoagulant trials of venous thromboembolism treatment. J Thromb Haemost 23(4): 1315-1331, 2025.
Male C, Lensing AWA, Chan AKC, Kenet G, Young G, Bhat R, Pap AF, Kubitza D, Prins MH, Monagle P; EINSTEIN-Jr Phase 3 Investigators: Extended-phase anticoagulant treatment of acute venous thromboembolism in children: a cohort study from the EINSTEIN-Jr phase 3 trial. Lancet Haemotol 12(5): e357-e364, 2025.
Whitworth H, Wagner K, Zelinski A, DiCocco E, Goodwin Davies AJ, Jordan R, Higginbotham M, O'Byrne ML, Bailey LC, Raffini L, Rajpurkar M: A novel Computable phENotype To Identify Pulmonary Embolism in chilDrEn: The CENTIPEDE Study. Thromb Res 253, 2025.
Faustino EVS, Kandil SB, Leroue MK, Sochet AA, Kong M, Cholette JM, Nellis ME, Pinto MG, Chegondi M, Ramirez M, Schreiber H, Kerris EWJ, Glau CL, Kolmar A, Muisyo TM, Sharathkumar A, Polikoff L, Silva CT, Ehrlich L, Navarro OM, Spinella PC, Raffini L, Taylor SN, McPartland T, Shabanova V; Catheter-Related Early Thromboprophylaxis with Enoxaparin (CRETE) Studies Investigators and the Pediatric Critical Care Blood Research Network (BloodNet) of the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI): Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies. Pediatr Crit Care Med 26(1): e95-e105, 2025.
Monagle P, Azzam M, Bercovitz R, Betensky M, Bhat R, Biss T, Branchford B, Brandão LR, Chan AKC, Faustino EVS, Jaffray J, Jones S, Kawtharany H, Kerlin BA, Kucine N, Kumar R, Male C, Pelland-Marcotte MC, Raffini L, Raulji C, Sartain SE, Takemoto CM, Tarango C, van Ommen CH, Velez MC, Vesely SK, Wiernikowski J, Williams S, Wilson HP, Woods G, Zia A, Mustafa RA.: American Society of Hematology/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients. Blood Adv 9(10): 2587-2636, 2025.
Zia A, Nelson MD, Ren J, Zhang S, Mattrey RF, Han BL, Hussain T, Greer JS, Al-Qahtani M, Malone K, Stutzman SE, Sida DV, Primeaux S, Torres MD, Cohen CT, Crary S, Bernstein J, Whitworth HB, Kumar R, Beg KA, Khan O, Rajpurkar M, Hege K, Schaefer BA, Woods GM, Amos LE, Betensky M, Bhat RV, O' Brien S, Jaffray J, Jesudas R, Pacheco MM, Tarango C, Weyand AC, Wilson HP, Garcia J, Dang MP, Sharma R, Goldenberg NA, Klok FA, Male C, Levine B, Balmain BN, Babb TG; FUVID Investigators: The Functional Characterization of Venous Thromboembolic Disease (FUVID) study: rationale, design, and methods of a prospective, observational, multicenter study to evaluate mechanisms of exercise intolerance and dyspnea following pediatric pulmonary embolism. Res Pract Thromb Haemost 9(1), 2024.
Whitworth H., Wagner K., Zelenski A., DiCocco E., Davies A., Jordan R., Higginbotham M., Bailey C., Raffini L.: Computable phENotype To Identify Pulmonary Embolism in chilDrEn: The CENTIPEDE study. ISTH Annual Meeting Bangkok, Thailand 2024.
Rastogi R., Okunwono O., Faerber J., Mavroudis C., Whitworth H., Giglia T., Witmer C., Raffini L., O’Byrne M. : Incidence, management and outcomes of pediatric pulmonary embolism in the United States: An observational study using data from the Pediatric Health Information System Database. JACC Adv. 3(4): 100895, 2024.
Zantek N., Steiner M., Teruya J., Baumann-Kreuziger L., Raffini L., Muszynski J., Alexander P., Watt K.: Recommendations on monitoring and replacement of antithrombin, fibrinogen and von Willebrand factor in pediatric patients on ECMO from the Pediatric ECMO Anticoagulation Collaborative (PEACE) Consensus Conference Series. Pediatr Crit Care Med 25(7): e35-43, 2024.