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Jonathan M. Spergel, MD, PhD
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Professor of Pediatrics (Allergy/Immunology) at the Children's Hospital of Philadelphia
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Director, Food Allergy Center/ Center for Pedidatric Eosinophilic Disorders,, The Children’s Hospital of Philadelphia
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Chief, Allergy Section, The Children's Hospital of Philadelphia
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Division of Allergy and Immunology
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memeber, Institute for Translational Medicine and Therapeutics
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member, Institute for Immunology
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Stuart E. Starr Endowed Chair in Pediatrics, The Children's Hospital of Philadelphia
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Department: Pediatrics
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Contact information
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3501 Civic Center Blvd
26 HUB for Clinical Colloboration
11 Rm 13-521
48 Children’s Hospital of Philadelphia
Philadelphia, PA 19104
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26 HUB for Clinical Colloboration
11 Rm 13-521
48 Children’s Hospital of Philadelphia
Philadelphia, PA 19104
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Office: 215-590-2549
30 Fax: 2155904529
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30 Fax: 2155904529
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Email:
SPERGEL@chop.edu
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SPERGEL@chop.edu
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Education:
21 9 A.B. 16 (Chemistry) c
2d Princeton University, 1985.
21 a Ph.D. 20 (Biomedical Sciences) c
35 Mt. Sinai School of Medicine, 1992.
21 9 M.D. c
35 Mt. Sinai School of Medicine, 1992.
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Permanent link21 9 A.B. 16 (Chemistry) c
2d Princeton University, 1985.
21 a Ph.D. 20 (Biomedical Sciences) c
35 Mt. Sinai School of Medicine, 1992.
21 9 M.D. c
35 Mt. Sinai School of Medicine, 1992.
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Description of Research Expertise
6b eosinophilic esophagitis, food allergy, gastrointestinal food allergy and atopic dermatitis65
Description of Clinical Expertise
6a atopic dermatitis, food allergy, asthma, allergic rhinitis, general allergy and immunology1a 29
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172 Paller AS, Eichenfield LF, Irvine AD, Flohr C, Wollenberg A, Barbarot S, Bangert C, Spergel JM, Selfridge A, Biswas P, Fan H, Alderfer J, Watkins M, Koppensteiner H.: Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate-to-Severe Atopic Dermatitis. Allergy Mar 2025.
16d Dupuis R, Spergel JM, Brown-Whitehorn TF, Troxel AB, Kenney EL, Block JP, Feuerstein-Simon R, Marti XL, Mollen CJ, Meisel ZF, Volpp KG, Gortmaker SL, Cannuscio CC.: Incidence of food allergic reactions among adolescents engaged in food allergy management. Ann Allergy Asthma Immunol Mar 2025.
120 Chidambaram AG, Cielo CM, Chervoneva I, Spergel JM, Tapia IE.: Nasal biomarker inflammatory profile in response to intranasal corticosteroids in pediatric obstructive sleep apnea syndrome. J Clin Sleep Med Mar 2025.
1d2 Chinthrajah RS, Sindher SB, Nadeau KC, Leflein JG, Spergel JM, Petroni DH, Jones SM, Casale TB, Wang J, Carr WW, Shreffler WG, Wood RA, Wambre E, Liu J, Akinlade B, Atanasio A, Orengo JM, Hamilton JD, Kamal MA, Hooper AT, Patel K, Laws E, Mannent LP, Adelman DC, Ratnayake A, Radin AR.: Dupilumab as an Adjunct to Oral Immunotherapy in Pediatric Patients With Peanut Allergy. Allergy Mar 2025.
1e9 Kliewer KL, Abonia JP, Aceves SS, Atkins D, Bonis PA, Capocelli KE, Chehade M, Collins MH, Dellon ES, Fei L, Furuta GT, Gupta SK, Kagalwalla A, Leung J, Mir S, Mukkada VA, Pesek R, Rosenberg C, Shoda T, Spergel JM, Sun Q, Wechsler JB, Yang GY, Rothenberg ME.: One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: A multisite randomized trial. J Allergy Clin Immunol 155: 520-32, Feb 2025.
13b Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA.: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. J Allergy Clin Immunol Jan 2025.
150 Spergel JM, Chehade M, Dellon ES, Bredenoord AJ, Sun X, Glotfelty L, Shabbir A, Tilton ST, McCann E.: Dupilumab Improves Health-Related Quality of Life and a Range of Symptoms in Patients With Eosinophilic Esophagitis. Am J Gastroenterol 119: 2398-2407, Dec 2024.
209 Kim S, Ben-Baruch Morgenstern N, Osonoi K, Aceves SS, Arva NC, Chehade M, Collins MH, Dellon ES, Falk GW, Furuta GT, Gonsalves NP, Gupta SK, Hirano I, Hiremath G, Katzka DA, Khoury P, Leung J, Pesek R, Peterson KA, Pletneva MA, Spergel JM, Wechsler JB, Yang GY, Rothenberg ME, Shoda T.: Nonepithelial Gene Expression Correlates With Symptom Severity in Adults With Eosinophilic Esophagitis. J Allergy Clin Immunol Pract 12(12): 3346-3351, Dec 2024.
1fa Martin LJ, Zhang X, Chehade M, Davis CM, Dellon ES, Falk GW, Gupta SK, Hirano I, Hiremath GS, Katzka DA, Khoury P, Leung J, Menard-Katcher P, Gonsalves N, Pesek RD, Spergel JM, Wechsler JB, Kliewer K, Arva NC, Collins MH, Pletneva M, Yang GY, Furuta GT, Rothenberg ME, Aceves SS.: Long-term durability between parent and child patient-reported outcomes in eosinophilic esophagitis. J Allergy Clin Immunol 154(5): 1232-1240, Nov 2024.
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Selected Publications
163 Zhou X, Dunham D, Sindher SB, Long A, Fernandes A, Chang I, Assa'ad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Boyd SD, Chinthrajah RS, Nadeau KC.: HLA-DR(+) regulatory T cells and IL-10 are associated with success or failure of desensitization outcomes. Allergy Mar 2025.172 Paller AS, Eichenfield LF, Irvine AD, Flohr C, Wollenberg A, Barbarot S, Bangert C, Spergel JM, Selfridge A, Biswas P, Fan H, Alderfer J, Watkins M, Koppensteiner H.: Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate-to-Severe Atopic Dermatitis. Allergy Mar 2025.
16d Dupuis R, Spergel JM, Brown-Whitehorn TF, Troxel AB, Kenney EL, Block JP, Feuerstein-Simon R, Marti XL, Mollen CJ, Meisel ZF, Volpp KG, Gortmaker SL, Cannuscio CC.: Incidence of food allergic reactions among adolescents engaged in food allergy management. Ann Allergy Asthma Immunol Mar 2025.
120 Chidambaram AG, Cielo CM, Chervoneva I, Spergel JM, Tapia IE.: Nasal biomarker inflammatory profile in response to intranasal corticosteroids in pediatric obstructive sleep apnea syndrome. J Clin Sleep Med Mar 2025.
1d2 Chinthrajah RS, Sindher SB, Nadeau KC, Leflein JG, Spergel JM, Petroni DH, Jones SM, Casale TB, Wang J, Carr WW, Shreffler WG, Wood RA, Wambre E, Liu J, Akinlade B, Atanasio A, Orengo JM, Hamilton JD, Kamal MA, Hooper AT, Patel K, Laws E, Mannent LP, Adelman DC, Ratnayake A, Radin AR.: Dupilumab as an Adjunct to Oral Immunotherapy in Pediatric Patients With Peanut Allergy. Allergy Mar 2025.
1e9 Kliewer KL, Abonia JP, Aceves SS, Atkins D, Bonis PA, Capocelli KE, Chehade M, Collins MH, Dellon ES, Fei L, Furuta GT, Gupta SK, Kagalwalla A, Leung J, Mir S, Mukkada VA, Pesek R, Rosenberg C, Shoda T, Spergel JM, Sun Q, Wechsler JB, Yang GY, Rothenberg ME.: One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: A multisite randomized trial. J Allergy Clin Immunol 155: 520-32, Feb 2025.
13b Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA.: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. J Allergy Clin Immunol Jan 2025.
150 Spergel JM, Chehade M, Dellon ES, Bredenoord AJ, Sun X, Glotfelty L, Shabbir A, Tilton ST, McCann E.: Dupilumab Improves Health-Related Quality of Life and a Range of Symptoms in Patients With Eosinophilic Esophagitis. Am J Gastroenterol 119: 2398-2407, Dec 2024.
209 Kim S, Ben-Baruch Morgenstern N, Osonoi K, Aceves SS, Arva NC, Chehade M, Collins MH, Dellon ES, Falk GW, Furuta GT, Gonsalves NP, Gupta SK, Hirano I, Hiremath G, Katzka DA, Khoury P, Leung J, Pesek R, Peterson KA, Pletneva MA, Spergel JM, Wechsler JB, Yang GY, Rothenberg ME, Shoda T.: Nonepithelial Gene Expression Correlates With Symptom Severity in Adults With Eosinophilic Esophagitis. J Allergy Clin Immunol Pract 12(12): 3346-3351, Dec 2024.
1fa Martin LJ, Zhang X, Chehade M, Davis CM, Dellon ES, Falk GW, Gupta SK, Hirano I, Hiremath GS, Katzka DA, Khoury P, Leung J, Menard-Katcher P, Gonsalves N, Pesek RD, Spergel JM, Wechsler JB, Kliewer K, Arva NC, Collins MH, Pletneva M, Yang GY, Furuta GT, Rothenberg ME, Aceves SS.: Long-term durability between parent and child patient-reported outcomes in eosinophilic esophagitis. J Allergy Clin Immunol 154(5): 1232-1240, Nov 2024.
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