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Jonathan M. Spergel, MD, PhD
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Professor of Pediatrics (Allergy/Immunology) at the Children's Hospital of Philadelphia
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Physician in Allergy and Immunology, The Children’s Hospital of Philadelphia
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Director, Food Allergy Center/ Center for Pedidatric Eosinophilic Disorders,, The Children’s Hospital of Philadelphia
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Chief, Allergy Section, The Children's Hospital of Philadelphia
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Division of Allergy and Immunology
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memeber, Institute for Translational Medicine and Therapeutics
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member, Institute for Immunology
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Stuart E. Starr Endowed Chair in Pediatrics, The Children's Hospital of Philadelphia
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Department: Pediatrics
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Contact information
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3501 Civic Center Blvd
26 HUB for Clinical Colloboration
11 Rm 13-521
48 Children’s Hospital of Philadelphia
Philadelphia, PA 19104
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26 HUB for Clinical Colloboration
11 Rm 13-521
48 Children’s Hospital of Philadelphia
Philadelphia, PA 19104
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Office: 215-590-2549
30 Fax: 2155904529
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30 Fax: 2155904529
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Email:
SPERGEL@chop.edu
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SPERGEL@chop.edu
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Education:
21 9 A.B. 16 (Chemistry) c
2d Princeton University, 1985.
21 a Ph.D. 20 (Biomedical Sciences) c
35 Mt. Sinai School of Medicine, 1992.
21 9 M.D. c
35 Mt. Sinai School of Medicine, 1992.
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Permanent link21 9 A.B. 16 (Chemistry) c
2d Princeton University, 1985.
21 a Ph.D. 20 (Biomedical Sciences) c
35 Mt. Sinai School of Medicine, 1992.
21 9 M.D. c
35 Mt. Sinai School of Medicine, 1992.
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Description of Research Expertise
6b eosinophilic esophagitis, food allergy, gastrointestinal food allergy and atopic dermatitis65
Description of Clinical Expertise
6a atopic dermatitis, food allergy, asthma, allergic rhinitis, general allergy and immunology1a 29
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1aa Lim WK, Wipperman MF, Rothenberg ME, Collins MH, Hamon SC, Chehade M, Spergel JM, Gayvert KM, Ehmann PJ, Horowitz JE, Farrell AB, Dellon ES, Maloney J, Radin A, Louisias M, Wolfe K, Akinlade B, Ajithdoss DK, Herman G, Yancopoulos GD, Hamilton JD.: Dupilumab normalizes the eosinophilic esophagitis disease transcriptome. J Allergy Clin Immunol Apr 2026.
187 Chehade M, McCann E, Spergel J, Yaworsky A, Lamoureux RE, Litcher-Kelly L, Burbridge C, Sutter C, Newton L, Liu R, Tilton ST, Kamat S, Dellon ES.: Validation of the Novel Pediatric Eosinophilic Esophagitis Sign/Symptom Questionnaire-Caregiver Version in EoE KIDS. J Allergy Clin Immunol Pract 14(4): 899-906, Apr 2026.
195 Oppenheimer J, Casale TB, Spergel JM, Bernstein DI, Camargo CA Jr, Ellis AK, Fleischer DM, Lowenthal R, Tanimoto S.: Pharmacokinetics and Pharmacodynamics Following Repeat Dosing of neffy (Epinephrine Nasal Spray) Versus Intramuscular Injection During Induced Allergic Rhinitis. J Allergy Clin Immunol Pract 14(4): 837-45, Apr 2026.
170 Gabryszewski SJ, Hirabayashi K, Botdorf M, Maltenfort M, Forrest CB, Guilbert TW, Schutt M, Morizono H, Vazquez Garcia G, Garza-Mayers AC, Hernandez JD, Anvari S, Rao S, Spergel JM.: Incidence of autoimmune diseases in children with atopy treated with dupilumab. J Allergy Clin Immunol Mar 2026.
135 Buckey TM, Frangiosa J, Diem L, Hanna E, Datta R, Gober L, Brown-Whitehorn T, Spergel JM, Muir A, Cianferoni A.: Eosinophilic Esophagitis Incidence during Single and Multiple Food Oral Immunotherapy. Ann Allergy Asthma Immunol Feb 2026.
27c Chinthrajah RS, Kulis M, Jones SM, Sicherer S, Wang J, Shreffler W, Burk CM, Kim E, Keet C, Sindher S, Long AJ, Scurlock AM, Lanser BJ, Hui-Beckman JW, Vickery B, Ezhuthachan ID, Bird JA, Parrish C, Spergel JM, Brown-Whitehorn T, Dantzer J, Ligueros-Saylan M, Tassinari P, Olsson J, Iqbal A, Ozanne M, Huckabee C, Rogers N, Yovetich N, Lin A, Brittain E, Wheatley LM, Togias A, Wood RA.: Exploratory analyses of predictors and correlates of response to omalizumab therapy in patients with multiple food allergies. J Allergy Clin Immunol 157(2): 442-453, Feb 2026.
18e Rodríguez-López EM, Clement RL, Lal M, Zhou Y, Carro SD, Assenmacher CA, Gautam R, Beers J, Muir AB, Spergel JM, Ruffner MA, Eisenlohr LC, Hill DA.: Oesophageal Epithelial Cell-Intrinsic MHCII Regulates Food Antigen-Dependent Eosinophilic Esophagitis in an IFNγ-Dependent Manner. Clin Exp Allergy 56(2): 124-136, Feb 2026.
155 Dilollo J, Guerrier CM, De La Torre Saenz Rico I, Martin E, Lee S, Pratt M, Vinnakota P, Faig W, Paessler ME, Spergel JM, Hill DA.: Evaluation of Functional T-Cell Assays That Predict Causal Allergens in Eosinophilic Esophagitis. Diagnostics (Basel) 16: 175, Jan 2026.
118 Buckey TM, Navard-Keck A, Atalla J, Samandi L, Ram G, Spergel JM, Kennedy KL.: Seed allergy evaluation and outcomes in a pediatric food challenge center. J Allergy Clin Immunol Pract 14(1): 297-99, Jan 2026.
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Selected Publications
166 Wolfset N, Muir AB, Benitez AJ, Williams D, De La Torre I, Ruffner MA, Hill DA, Cazeau C, Angello JT, Radwan A, Durrani S, deMarchi S, Spergel JM.: Efficacy of Dupilumab on Facilitated Food Reintroduction in Eosinophilic Esophagitis. Clin Gastroenterol Hepatol 24(5): 1271-9, May 2026.1aa Lim WK, Wipperman MF, Rothenberg ME, Collins MH, Hamon SC, Chehade M, Spergel JM, Gayvert KM, Ehmann PJ, Horowitz JE, Farrell AB, Dellon ES, Maloney J, Radin A, Louisias M, Wolfe K, Akinlade B, Ajithdoss DK, Herman G, Yancopoulos GD, Hamilton JD.: Dupilumab normalizes the eosinophilic esophagitis disease transcriptome. J Allergy Clin Immunol Apr 2026.
187 Chehade M, McCann E, Spergel J, Yaworsky A, Lamoureux RE, Litcher-Kelly L, Burbridge C, Sutter C, Newton L, Liu R, Tilton ST, Kamat S, Dellon ES.: Validation of the Novel Pediatric Eosinophilic Esophagitis Sign/Symptom Questionnaire-Caregiver Version in EoE KIDS. J Allergy Clin Immunol Pract 14(4): 899-906, Apr 2026.
195 Oppenheimer J, Casale TB, Spergel JM, Bernstein DI, Camargo CA Jr, Ellis AK, Fleischer DM, Lowenthal R, Tanimoto S.: Pharmacokinetics and Pharmacodynamics Following Repeat Dosing of neffy (Epinephrine Nasal Spray) Versus Intramuscular Injection During Induced Allergic Rhinitis. J Allergy Clin Immunol Pract 14(4): 837-45, Apr 2026.
170 Gabryszewski SJ, Hirabayashi K, Botdorf M, Maltenfort M, Forrest CB, Guilbert TW, Schutt M, Morizono H, Vazquez Garcia G, Garza-Mayers AC, Hernandez JD, Anvari S, Rao S, Spergel JM.: Incidence of autoimmune diseases in children with atopy treated with dupilumab. J Allergy Clin Immunol Mar 2026.
135 Buckey TM, Frangiosa J, Diem L, Hanna E, Datta R, Gober L, Brown-Whitehorn T, Spergel JM, Muir A, Cianferoni A.: Eosinophilic Esophagitis Incidence during Single and Multiple Food Oral Immunotherapy. Ann Allergy Asthma Immunol Feb 2026.
27c Chinthrajah RS, Kulis M, Jones SM, Sicherer S, Wang J, Shreffler W, Burk CM, Kim E, Keet C, Sindher S, Long AJ, Scurlock AM, Lanser BJ, Hui-Beckman JW, Vickery B, Ezhuthachan ID, Bird JA, Parrish C, Spergel JM, Brown-Whitehorn T, Dantzer J, Ligueros-Saylan M, Tassinari P, Olsson J, Iqbal A, Ozanne M, Huckabee C, Rogers N, Yovetich N, Lin A, Brittain E, Wheatley LM, Togias A, Wood RA.: Exploratory analyses of predictors and correlates of response to omalizumab therapy in patients with multiple food allergies. J Allergy Clin Immunol 157(2): 442-453, Feb 2026.
18e Rodríguez-López EM, Clement RL, Lal M, Zhou Y, Carro SD, Assenmacher CA, Gautam R, Beers J, Muir AB, Spergel JM, Ruffner MA, Eisenlohr LC, Hill DA.: Oesophageal Epithelial Cell-Intrinsic MHCII Regulates Food Antigen-Dependent Eosinophilic Esophagitis in an IFNγ-Dependent Manner. Clin Exp Allergy 56(2): 124-136, Feb 2026.
155 Dilollo J, Guerrier CM, De La Torre Saenz Rico I, Martin E, Lee S, Pratt M, Vinnakota P, Faig W, Paessler ME, Spergel JM, Hill DA.: Evaluation of Functional T-Cell Assays That Predict Causal Allergens in Eosinophilic Esophagitis. Diagnostics (Basel) 16: 175, Jan 2026.
118 Buckey TM, Navard-Keck A, Atalla J, Samandi L, Ram G, Spergel JM, Kennedy KL.: Seed allergy evaluation and outcomes in a pediatric food challenge center. J Allergy Clin Immunol Pract 14(1): 297-99, Jan 2026.
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