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Jonathan M. Spergel, MD, PhD

Jonathan M. Spergel, MD, PhD

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Professor of Pediatrics at the Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
3550 Market Street, Rm 3050
Children’s Hospital of Philadelphia
Philadelphia, PA 19104
Office: 215-590-6992
Fax: 2155904529
Education:
A.B. (Chemistry)
Princeton University, 1985.
Ph.D. (Biomedical Sciences)
Mt. Sinai School of Medicine, 1992.
M.D.
Mt. Sinai School of Medicine, 1992.
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Description of Research Expertise

eosinophilic esophagitis, food allergy, gastrointestinal food allergy and atopic dermatitis

Description of Clinical Expertise

atopic dermatitis, food allergy, asthma, allergic rhinitis, general allergy and immunology

Selected Publications

Merves, J., Chandramouleeswaran, P. M., Benitez, A. J., Muir, A. B., Lee, A. J., Lim, D. M., Dods, K., Mehta, I., Ruchelli, E. D., Nakagawa, H., Spergel, J. M., Wang, M. L.: Altered Esophageal Histamine Receptor Expression in Eosinophilic Esophagitis (EoE): Implications on Disease Pathogenesis. PLoS One 10(2): e0114831, 2015.

Hill, D. A., Shuker, M., Cianferoni, A., Wong, T., Ruchelli, E., Spergel, J. M., Brown-Whitehorn, T. F.: The development of IgE-mediated immediate hypersensitivity after the diagnosis of eosinophilic esophagitis to the same food. J Allergy Clin Immunol Pract 3(1): 123-4, 2015.

Luger, T., Boguniewicz, M., Carr, W., Cork, M., Deleuran, M., Eichenfield, L., Eigenmann, P., Folster-Holst, R., Gelmetti, C., Gollnick, H., Hamelmann, E., Hebert, A. A., Muraro, A., Oranje, A. P., Paller, A. S., Paul, C., Puig, L., Ring, J., Siegfried, E., Spergel, J. M., Stingl, G., Taieb, A., Torrelo, A., Werfel, T., Wahn, U.: Pimecrolimus in atopic dermatitis: consensus on safety and the need to allow use in infants. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2015.

Noti Mario, Kim Brian S, Siracusa Mark C, Rak Gregory D, Kubo Masato, Moghaddam Amin E, Sattentau Quentin A, Comeau Michael R, Spergel Jonathan M, Artis David: Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. The Journal of allergy and clinical immunology Feb 2014.

Jyonouchi S, Smith C L, Saretta F, Abraham V, Ruymann K R, Modayur-Chandramouleeswaran P, Wang M-L, Spergel J M, Cianferoni A: Invariant natural killer T cells in children with eosinophilic esophagitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 44(1): 58-68, Jan 2014.

Sleiman, P. M., Wang, M. L., Cianferoni, A., Aceves, S., Gonsalves, N., Nadeau, K., Bredenoord, A. J., Furuta, G. T., Spergel, J. M., Hakonarson, H.: GWAS identifies four novel eosinophilic esophagitis loci. Nat Commun 5: 5593, 2014.

Liacouras, C. A., Spergel, J., Gober, L. M.: Eosinophilic esophagitis: clinical presentation in children. Gastroenterol Clin North Am 43(2): 219-29, 2014.

Butz, B. K., Wen, T., Gleich, G. J., Furuta, G. T., Spergel, J., King, E., Kramer, R. E., Collins, M. H., Stucke, E., Mangeot, C., Jackson, W. D., O'Gorman, M., Abonia, J. P., Pentiuk, S., Putnam, P. E., Rothenberg, M. E.: Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology 147(2): 324-33 e5, 2014.

Cianferoni, A., Spergel, J. M.: Immunotherapeutic approaches for the treatment of eosinophilic esophagitis. Immunotherapy 6(3): 321-31, 2014.

Maggadottir, S. M., Hill, D. A., Ruymann, K., Brown-Whitehorn, T. F., Cianferoni, A., Shuker, M., Wang, M. L., Chikwava, K., Verma, R., Liacouras, C. A., Spergel, J. M.: Resolution of acute IgE-mediated allergy with development of eosinophilic esophagitis triggered by the same food. J Allergy Clin Immunol 133(5): 1487-9, 1489 e1, 2014.

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Last updated: 03/02/2015
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