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Alexis A. Topjian, MD, MSCE
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Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
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Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
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Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
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Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
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Associate Chair, Faculty Affairs, Children's Hospital of Philadephia
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Department: Anesthesiology and Critical Care
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Contact information
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Children's Hospital of Philadelphia
3b Department of Anesthesia and Critical Care Medicine
3e 3401 Civic Center Boulevard
Philadelphia, PA 19104
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3b Department of Anesthesia and Critical Care Medicine
3e 3401 Civic Center Boulevard
Philadelphia, PA 19104
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Office: 215-590-3915
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Email:
topjian@email.chop.edu
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topjian@email.chop.edu
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Education:
21 7 BA 14 (Biology) c
28 Harvard College, 1996.
21 7 MD 15 (Medicine) c
42 Columbia College of Physicians & Surgeons, 2001.
21 9 MSCE 3f (Masters in Clinical Epidemiology and Biostatistics) c
46 University of Pennsylvania School of Medicine, 2011.
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Permanent link21 7 BA 14 (Biology) c
28 Harvard College, 1996.
21 7 MD 15 (Medicine) c
42 Columbia College of Physicians & Surgeons, 2001.
21 9 MSCE 3f (Masters in Clinical Epidemiology and Biostatistics) c
46 University of Pennsylvania School of Medicine, 2011.
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17d Ullman NL, Reeder RW, Topjian A, Morgan RW, Berg RA, Nadkarni VM, Palmer CA, Sutton RM, Press CA, Kirschen MP; ICU-RESUS, CPCCRN Investigators: Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest. Resuscitation 218: 110886, January 2026.
16d Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo A, Huh JW, Lang S-S, Berg RA, Topjian AA, Press C, Kirschen MP: Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury. Neurocritical Care January 2026 Notes: Online ahead of print.
177 McSherry ML, Graham K, Woods-Hill CZ, Herrmann JR, Kirschen MP, Fowler JC, Gardner MM, Morgan RW, Sutton RM, Topjian A: Timing and mode of death after pediatric in- and out-of-hospital cardiac arrest: a single center retrospective study. Resuscitation 217: 110902, December 2025 Notes: Epub 2025 Nov 1.
158 Alcamo AM, Lieberman L, Sherry N, Ford HR, Fitzgerald JC, Topjian AA, Carcillo JA, Kochanek PM, Viaene AN, Aneja RK: Neuropathologic Autopsy Findings in Pediatric Sepsis: A Two-Center, Retrospective Study. Pediatr Crit Care Med December 2025 Notes: Online ahead of print.
172 Shepard LN, Reeder RW, Hsu J, Keim G, Berg RA, Sutton RM, Topjian AA, Yehya N, Morgan RW; American Heart Association’s Get With The Guidelines–Resuscitation Investigators: Intubation Trends and Survival in Pediatric In-Hospital Cardiac Arrest. Jama Network Open 8(11): e2544365, November 2025.
3d2 Becker AE, Abend NS, Benedetti GM, Buttram SDW, Chung MG, Erklauer JC, Friess SH, Hong SJ, Huh J, Kirschen MP, LaRovere KL, Lovett ME, Schober ME, Smith KA, Wolfe K, Zurca AD, Topjian AA, Boyer DL; Collaborators: Agarwal K, Appavu BL, Banwell B, Beslow LA, Castro D, Carpenter JL, Dominick C, Donoghue AJ, Conohue C, Fainberg NA, Flahery MR, Fung FW, Guilliams KP, Hamilton MF, Hodges ZT, Ichord R, Jacobwitz MN, Kennedy BC, Lang SS, Lockman JL, Lydon A, Milillo JR, Mink Richard, Mulvihill CA, Newmyer RE, Poeppelman RS, Press CA, Rosenblatt SA, Semless KR, Simon DW, Smith CM, Spaeder MC, Vossough A, Wainwright MS, Werner JA: Neurocritical Care Entrustable Professional Activities for Pediatric Critical Care Medicine Education and Professional Development: Standardizing Curriculum, Training, and Assessment. Pediatric Critical Care Medicine 26(11): e1394-e1402, November 2025 Notes: Epub 2025 Sep 9.
167 Silva LEV, Chen CC, Press CA, Graham K, Shi L, Abend NS, Morgan RW, Topjian A, Tsui FR, Kirschen MP: Pediatric cardiac arrest outcome prediction using data-driven machine learning of early quantitative electroencephalogram (qEEG) features. Resuscitation 216: 110854, November 2025 Notes: Epub 2025 Oct 8. 14
1b4 Loaec M, Keim G, Graham K, Kienzle MF, O'Halloran A, Shepard LN, Mehta S, Sawhney S, Donoghue M, Cooper K, Kilbaugh TJ, Nadkarni V, Topjian AA, Berg RA, Sutton RM, Morgan RW: Comparison of vasopressin to epinephrine during pediatric in-hospital cardiac arrest: survival and physiologic responsiveness. Pediatric Research October 2025 Notes: Online ahead of print.
210 Becker AE, Abend NS, Benedetti GM, Buttram SDW, Chung MG, Erklauer JC, Friess SH, Hong SJ, Huh J, Kirschen MP, LaRovere KL, Lovett ME, Schober ME, Smith KA, Wolfe K, Zurca AD, Topjian AA, Boyer DL; Collaborators: Neurocritical Care Entrustable Professional Activities for Pediatric Critical Care Medicine Education and Professional Development: Standardizing Curriculum, Training, and Assessment. Pediatr Crit Care Med Epub ahead of print, September 2025.
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Selected Publications
13b Silva LEV, Balcarcel D, Ko TS, Morgan RW, Berg RA, Topjian A, Tsui FR, Kirschen MP: Prediction of neurological outcome after pediatric cardiac arrest using heart rate variability and machine learning. Resuscitation 219: 110961, February 2026.17d Ullman NL, Reeder RW, Topjian A, Morgan RW, Berg RA, Nadkarni VM, Palmer CA, Sutton RM, Press CA, Kirschen MP; ICU-RESUS, CPCCRN Investigators: Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest. Resuscitation 218: 110886, January 2026.
16d Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo A, Huh JW, Lang S-S, Berg RA, Topjian AA, Press C, Kirschen MP: Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury. Neurocritical Care January 2026 Notes: Online ahead of print.
177 McSherry ML, Graham K, Woods-Hill CZ, Herrmann JR, Kirschen MP, Fowler JC, Gardner MM, Morgan RW, Sutton RM, Topjian A: Timing and mode of death after pediatric in- and out-of-hospital cardiac arrest: a single center retrospective study. Resuscitation 217: 110902, December 2025 Notes: Epub 2025 Nov 1.
158 Alcamo AM, Lieberman L, Sherry N, Ford HR, Fitzgerald JC, Topjian AA, Carcillo JA, Kochanek PM, Viaene AN, Aneja RK: Neuropathologic Autopsy Findings in Pediatric Sepsis: A Two-Center, Retrospective Study. Pediatr Crit Care Med December 2025 Notes: Online ahead of print.
172 Shepard LN, Reeder RW, Hsu J, Keim G, Berg RA, Sutton RM, Topjian AA, Yehya N, Morgan RW; American Heart Association’s Get With The Guidelines–Resuscitation Investigators: Intubation Trends and Survival in Pediatric In-Hospital Cardiac Arrest. Jama Network Open 8(11): e2544365, November 2025.
3d2 Becker AE, Abend NS, Benedetti GM, Buttram SDW, Chung MG, Erklauer JC, Friess SH, Hong SJ, Huh J, Kirschen MP, LaRovere KL, Lovett ME, Schober ME, Smith KA, Wolfe K, Zurca AD, Topjian AA, Boyer DL; Collaborators: Agarwal K, Appavu BL, Banwell B, Beslow LA, Castro D, Carpenter JL, Dominick C, Donoghue AJ, Conohue C, Fainberg NA, Flahery MR, Fung FW, Guilliams KP, Hamilton MF, Hodges ZT, Ichord R, Jacobwitz MN, Kennedy BC, Lang SS, Lockman JL, Lydon A, Milillo JR, Mink Richard, Mulvihill CA, Newmyer RE, Poeppelman RS, Press CA, Rosenblatt SA, Semless KR, Simon DW, Smith CM, Spaeder MC, Vossough A, Wainwright MS, Werner JA: Neurocritical Care Entrustable Professional Activities for Pediatric Critical Care Medicine Education and Professional Development: Standardizing Curriculum, Training, and Assessment. Pediatric Critical Care Medicine 26(11): e1394-e1402, November 2025 Notes: Epub 2025 Sep 9.
167 Silva LEV, Chen CC, Press CA, Graham K, Shi L, Abend NS, Morgan RW, Topjian A, Tsui FR, Kirschen MP: Pediatric cardiac arrest outcome prediction using data-driven machine learning of early quantitative electroencephalogram (qEEG) features. Resuscitation 216: 110854, November 2025 Notes: Epub 2025 Oct 8. 14
1b4 Loaec M, Keim G, Graham K, Kienzle MF, O'Halloran A, Shepard LN, Mehta S, Sawhney S, Donoghue M, Cooper K, Kilbaugh TJ, Nadkarni V, Topjian AA, Berg RA, Sutton RM, Morgan RW: Comparison of vasopressin to epinephrine during pediatric in-hospital cardiac arrest: survival and physiologic responsiveness. Pediatric Research October 2025 Notes: Online ahead of print.
210 Becker AE, Abend NS, Benedetti GM, Buttram SDW, Chung MG, Erklauer JC, Friess SH, Hong SJ, Huh J, Kirschen MP, LaRovere KL, Lovett ME, Schober ME, Smith KA, Wolfe K, Zurca AD, Topjian AA, Boyer DL; Collaborators: Neurocritical Care Entrustable Professional Activities for Pediatric Critical Care Medicine Education and Professional Development: Standardizing Curriculum, Training, and Assessment. Pediatr Crit Care Med Epub ahead of print, September 2025.
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