Alexis A. Topjian, MD, MSCE

Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
Director, Pediatric Neurocritical Care Program, Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Associate Chief, Faculty Affairs, Critical Care Medicine, Children's Hospital of Philadelphia
Associate Chair, Faculty Affairs, Children's Hospital of Philadephia
Department: Anesthesiology and Critical Care
Contact information
Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Fax: 215-590-4327
Email:
topjian@email.chop.edu
topjian@email.chop.edu
Education:
BA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
Permanent linkBA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
Selected Publications
Janas AM, Miller KR, Ceschin R, Mourani PM, Ruzas CM, Bennett TD, Fink EL, Maddux AB; Personalizing Outcomes After Child Cardiac Arrest (POCCA) Investigators: Early Blood Biomarkers and MRI Injury After Cardiac Arrest: Secondary Analysis of the 2017-2020 "Personalized Outcomes After Child Cardiac Arrest" Study. Pediatr Crit Care Med Online ahead of print, April 2025.VanBuren JM, Yeatts SD, Holubkov R, Moler FW, Topjian A, Page K, Clevenger RG, Meurer WJ: The Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP): Statistical Methods Planned in the Bayesian, Adaptive, Duration Finding Trial. Pediatric Critical Care Medicine 26, Feb 2025.
Abend NS, Fung FW, Parikh D, Walsh K, Fitzgerald MP, Massey S, Topjian AA: Late-Onset Findings During Extended EEG Monitoring Are Rare in Critically Ill Children. Journal of Clinical Neurophysiology 42(2): 149-155, February 2025.
Fung FW, Parikh DS, Donnelly M, Xiao R, Topjian AA, Abend NS: Electrographic Seizure Characteristics and Electrographic Status Epilepticus Prediction. Journal of Clinical Neurophysiology 42(1): 64-72, January 2025.
Kirschen MP, Ullman NL, Reeder RW, Ahmed T, Bell MJ, Berg RA, Burns C, Carcillo JA, Carpenter TC, Diddle J, Federman M, Fink EL, Frazier AH, Friess SH, Graham K, Horvat CM, Huard LL, Kilbaugh TJ, Maa T, Manga A, McQuillen PS, Meert KL, Morgan RW, Mourani PM, Nadkarni VM, Naim MY, Notterman D, Palmer CA, Pollack MM, Sapru A, Sharron MP, Srivastava N, Tilford B, Viteri S, Wolfe HA, Yates AR, Topjian A, Sutton RM, Press CA: Practice patterns for acquiring neuroimaging after pediatric in-hospital cardiac arrest. Resuscitation 207: 110506, January 2025.
Gardner MM, Morgan RW, Reeder R, Ghaffari K, Ortmann L, Raymond T, Lasa JJ, Fowler J, Dewan M, Nadkarni VM, Berg R, Sutton R, Topjian AA, for the American Heart Association’s Get With The Guidelines, ®-Resuscitation Investigators: Trends in cardiac arrest outcomes & management in children with cardiac illness category compared to non-cardiac illness category: An analysis from the AHA Get With The Guidelines®-Resuscitation Registry. Resuscitation 205, December 2024.
Ushpol A, Je S, Christoff A, Nuthall G, Scholefield B, Morgan RW, Nadkarni V, Gangadharan S; pediRES-Q investigators: Evaluating post-cardiac arrest blood pressure thresholds associated with neurologic outcome in children: Insights from the pediRES-Q database. Resuscitation Online ahead of print, December 2024.
Fowler JC, Morgan RW, O'Halloran A, Gardner MM, Appel S, Wolfe H, Kienzle MF, Raymond TT, Scholefield RB, Guerguerian A, Bembea MM, Nadkarni V, Berg RA, Topjian AA, American Heart Association’s Get With The Guidelines®-Resuscitation Investigators: The Impact of Pediatric Post-Cardiac Arrest Care on Survival: A Multicenter Review from the AHA Get With The Guidelines®-Resuscitation Post-Cardiac Arrest Care Registry. Resuscitation 202: 110301, September 2024 Notes: Multicenter Study.
Liu R, Majumdar T, Gardner MM, Burnett R, Graham K, Beaulieu F, Sutton RM, Nadkarni VM, Berg RA, Morgan RW, Topjian AA, Kirschen MP: Association of Postarrest Hypotension Burden With Unfavorable Neurologic Outcome After Pediatric Cardiac Arrest. Crit Care Med 52, Sept 2024.
Mazzio EL, Topjian AA, Reeder RW, Sutton RM, Morgan RW, Berg RA, Nadkarni VM, Wolfe HA, Graham K, Naim MY, Friess SH, Abend NS, Press CA; ICU-RESUS Eunice Kennedy Shriver National Institute of Child Health; Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups.: Association of EEG characteristics with outcomes following pediatric ICU cardiac arrest: A secondary analysis of the ICU-RESUScitation trial. Resuscitation 201, Aug 2024.