Alexis A. Topjian, MD, MSCE

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Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
Fellowship Director, Pediatric Neurocritical Care , Children's Hospital of Philadelphia, Philadelphia, PA
Director, Pediatric Neurocritical Care Program, Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Associate Chief, Faculty Affairs, Critical Care Medicine, Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Education:
BA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Selected Publications

Alcamo AM, Becker AE, Barren GJ, Hayes K, Pennington JW, Curley MAQ, Tasker RC, Balamuth F, Weiss SL, Fitzgerald JC, Topjian AA: Diagnostic Identification of Acute Brain Dysfunction in Pediatric Sepsis and Septic Shock in the Electronic Health Record: A Comparison of Four Definitions in a Reference Dataset. Pediatric Critical Care Medicine Epub ahead of print, May 2024.

Loaec M, Himebauch AS, Reeder R, Alvey JS, Race JA, Su L, Lasa JJ, Slovis JC, Raymond TT, Coleman R, Barney BJ, Kilbaugh TJ, Topjian AA, Sutton RM, Morgan RW, and the American Heart Association's Get With The Guidelines-Resuscitation Investigators: Outcomes of Extracorporeal Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest Among Children with Non-Cardiac Illness Categories. Critical Care Medicine 52(4): 551-562, April 2024.

Coleman K, Fung FW, Topjian A, Abend NS, Xiao R: Optimizing EEG monitoring in critically ill children at risk for electroencephalographic seizures. Seizure April 2024.

Bach AM, Kirschen MP, Fung FW, Abend NS, Ampah S, Mondal A, Huh JW, Chen SL, Yuan I, Graham K, Berman JI, Vossough A, Topjian A: Association of EEG Background With Diffusion-Weighted Magnetic Resonance Neuroimaging and Short-Term Outcomes After Pediatric Cardiac Arrest. Neurology 102(5): e209134, March 2024.

Frazier AH, Topjian AA, Reeder RW, Morgan RW, Fink EL, Franzon D, Graham K, Harding ML, Mourani PM, Nadkarni VM, Wolfe HA, Ahmed T, Bell MJ, Burns C, Carcillo JA, Carpenter TC, Diddle JW, Federman M, Friess SH, Hall M, Hehir DA, Horvat CM, Huard LL MD, Maa T, Meert KL, Naim MY, Notterman D, Pollack MM, Schneiter C, Sharron MP, Srivastava N, Viteri S, Wessel D, Yates AR, Sutton RM, Berg RA: Association of Pediatric Post-Cardiac Arrest Ventilation and Oxygenation with Survival Outcomes. Ann Am Thorac Soc Epub ahead of print, March 2024.

Kirschen MP, Ouyang M, Patel B, Berman JI, Burnett R, Berg RA, Diaz-Arrastia R, Topjian A, Huang H, Vossough A: Association between ASL MRI-derived cerebral blood flow and outcomes after pediatric cardiac arrest. Resuscitation Epub ahead of print, February 2024.

Raymond T, Topjian AA, Lasa J, Nadkarni VM, Kirschen MP, Petersen T, Wakeham M, Esangbedo I, Rajapreyar P, Sangmo Je, Griffis H, Zhang X, Francoeur: Cerebral Oximetry During Pediatric In-hospital Cardiac Arrest: A Multicenter Study of Survival and Neurologic Outcome. Critical Care Medicine Online ahead of print, January 2024.

Abend NS, Fung FW, Parikh D, Walsh K, Fitzgerald MP, Massey S, Topjian AA: Late Onset Findings During Extended EEG Monitoring Are Rare in Critically Ill Children. Journal of Clinical Neurophysiology Accepted 2024.

Fink E, Lovett M, Agners C, Guilliams K, Rodriguez I, Stulce C, Williams C, Drury K, Dapul H, Santos L, Robertson C, Francoeur C, Ferrazzano P, Schober M, Schober M, Dervan L, Wainwright M, Appavu B, Farias-Moeller R, Farias R, Snooks K, krishnan H, Giraldo J, Yacoub M, Emrath E, Holloway A, Nagpal A, Wellnitz K, Czech T, Even K, de Carvalho WB, Schwartz S, Walker T, Minos S, Geneslaw A, Deming WV, Silver WG, Topjian AA, Alcamo AM, McGuire J, Dominguez J, Hong S, Muller W, Doerfler M, Bhagat D, Nelson A, Price D, Walson K, Rasmussen LK, Chang CH, Yun J, Sherry C : Severe Neurologic Manifestations with SARS-CoV-2 Conditions and Outcomes in Hospitalized Children. JAMA Network Open Accepted 2024.

Ushpol A, Je S, Niles D, Majmudar T, Kirschen M, Del Castillo J, Buysse C, Topjian A, Nadkarni V, Gangadharan S; PediRES-Q investigators: Association of blood pressure with neurologic outcome at hospital discharge after pediatric cardiac arrest resuscitation. Resuscitation December 2023.

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Last updated: 05/20/2024
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