Alexis A. Topjian, MD, MSCE

faculty photo
Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
Fellowship Director, Pediatric Neurocritical Care , Children's Hospital of Philadelphia, Philadelphia, PA
Director, Pediatric Neurocritical Care Program, Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Associate Chief, Faculty Affairs, Critical Care Medicine, Children's Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Education:
BA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Selected Publications

Francoeur C, Alcamo AM, Robertson CL, Wainwright MS, Roa JD, Lovett ME, Stulce C, Yacoub M, Potera RM, Zivick E, Holloway A, Nagpal A, Wellnitz K, Even KM, Brunow de Carvalho W, Rodriguez IS, Schwartz SP, Walker TC, Campos-Miño S, Dervan LA, Geneslaw AS, Sewell TB, Pryce P, Silver WG, Lin JE, Vargas WS, Topjian A, McGuire JL, Domínguez Rojas JA, Tasayco-Muñoz J, Hong SJ, Muller WJ, Doerfler M, Williams CN, Drury K, Bhagat D, Nelson A, Price D, Dapul H, Santos L, Kahoud R, Appavu B, Guilliams KP, Agner SC, Walson KH, Rasmussen L, Pal R, Janas A, Ferrazzano P, Farias-Moeller R, Snooks KC, Chang CH, Iolster T, Erklauer JC, Jorro Baron F, Wassmer E, Yoong M, Jardine M, Mohammad Z, Deep A, Kendirli T, Lidsky K, Dallefeld S, Flockton H, Agrawal S, Siruguppa KS, Waak M, Gutiérrez-Mata A, Butt W, Bogantes-Ledezma S, Sevilla-Acosta F, Umaña-Calderón A, Ulate-Campos A, Yock-Corrales A, Talisa VB, Kanthimathinathan HK, Schober ME, Fink EL: Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity. Jama Network Open 7(6): e2414122, June 2024.

Barreto JA, Wenger J, Dewan M, Topjian A, Roberts J: Postcardiac Arrest Care Delivery in Pediatric Intensive Care Units: A Plan and Call to Action. Pediatr Qual Saf 9(3): e727, June 2024.

Mazzio EL, Topjian AA, Reeder RW, Sutton RM, Morgan RW, Berg RA, Nadkarni VM, Wolfe HA, Graham K, Naim MY, Friess SH, Abend NS, Press CA; ICU-RESUS Eunice Kennedy Shriver National Institute of Child Health, Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups: Association of EEG Characteristics with Outcomes Following Pediatric ICU Cardiac Arrest: A Secondary Analysis of the ICU-RESUScitation Trial Resuscitation Online ahead of print, June 2024.

Liu R, Majumdar T, Gardner MM, Burnett R, Graham K, Beaulieu F, Sutton RM, Nadkarni VM, Berg RA, Morgan RW, Topjian AA, Kirschen MP: Association of Postarrest Hypotension Burden With Unfavorable Neurologic Outcome After Pediatric Cardiac Arrest. Crit Care Med Online ahead of print, June 2024.

Jacobwitz M, Mulvihill C, Kaufman MC, Gonzalez AK, Resendiz K, Francoeur C, Helbig I, Topjian AA, Abend NS: A Comparison of Ketamine Versus Midazolam as First-Line Anesthetic Infusions for Pediatric Status Epilepticus. Neurocritical Care 40(3): 984-995, June 2024.

Mazzio EL, Topjian AA, Reeder RW, Sutton RM, Morgan RW, Berg RA, Nadkarni VM, Wolfe HA, Graham K, Naim MY, Friess SH, Abend NS, Press CA; ICU-RESUS Eunice Kennedy Shriver National Institute of Child Health; Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups: Association of EEG characteristics with outcomes following pediatric ICU cardiac arrest: A secondary analysis of the ICU-RESUScitation trial. Resuscitation Online ahead of print, June 2024.

Raymond T, Topjian AA, Lasa J, Nadkarni VM, Kirschen MP, Petersen T, Wakeham M, Esangbedo I, Rajapreyar P, Sangmo Je, Griffis H, Zhang X, Francoeur: Cerebral Oximetry During Pediatric In-hospital Cardiac Arrest: A Multicenter Study of Survival and Neurologic Outcome. Critical Care Medicine 52(5): 775-785, May 2024.

Alcamo AM, Becker AE, Barren GJ, Hayes K, Pennington JW, Curley MAQ, Tasker RC, Balamuth F, Weiss SL, Fitzgerald JC, Topjian AA: Diagnostic Identification of Acute Brain Dysfunction in Pediatric Sepsis and Septic Shock in the Electronic Health Record: A Comparison of Four Definitions in a Reference Dataset. Pediatric Critical Care Medicine Epub ahead of print, May 2024.

Fung FW, Parikh DS, Massey SL, Fitzgerald MP, Vala L, Donnelly M, Jacobwitz M, Kessler SK, Xiao R, Topjian AA, Abend NS: Periodic Discharges in Critically Ill Children: Predictors and Outcome. Journal of Clinical Neurophysiology 41(4): 297-304, May 2024.

Loaec M, Himebauch AS, Reeder R, Alvey JS, Race JA, Su L, Lasa JJ, Slovis JC, Raymond TT, Coleman R, Barney BJ, Kilbaugh TJ, Topjian AA, Sutton RM, Morgan RW, and the American Heart Association's Get With The Guidelines-Resuscitation Investigators: Outcomes of Extracorporeal Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest Among Children with Non-Cardiac Illness Categories. Critical Care Medicine 52(4): 551-562, April 2024.

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Last updated: 06/26/2024
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