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Alexis A. Topjian, MD, MSCE
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Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
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Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
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Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
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Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
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Associate Chair, Faculty Affairs, Children's Hospital of Philadephia
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Department: Anesthesiology and Critical Care
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Contact information
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Children's Hospital of Philadelphia
3b Department of Anesthesia and Critical Care Medicine
3e 3401 Civic Center Boulevard
Philadelphia, PA 19104
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3b Department of Anesthesia and Critical Care Medicine
3e 3401 Civic Center Boulevard
Philadelphia, PA 19104
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Office: 215-590-3915
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Email:
topjian@email.chop.edu
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topjian@email.chop.edu
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Education:
21 7 BA 14 (Biology) c
28 Harvard College, 1996.
21 7 MD 15 (Medicine) c
42 Columbia College of Physicians & Surgeons, 2001.
21 9 MSCE 3f (Masters in Clinical Epidemiology and Biostatistics) c
46 University of Pennsylvania School of Medicine, 2011.
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Permanent link21 7 BA 14 (Biology) c
28 Harvard College, 1996.
21 7 MD 15 (Medicine) c
42 Columbia College of Physicians & Surgeons, 2001.
21 9 MSCE 3f (Masters in Clinical Epidemiology and Biostatistics) c
46 University of Pennsylvania School of Medicine, 2011.
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1bc Shepard LN, Napolitano N, Dominick C, Nickel AJ, Shults J, Laverriere McGovern E, Bruins BB, O'Halloran A, Huh J, Topjian A, Kirschen MP, Morgan RW, Sutton RM, Nadkarni VM, Nishisaki A: Quality of Bag-Mask Ventilation for Children Before Intubation: Single-Center PICU Pilot Observational Study, 2019–2022. Pediatr Crit Care Med March 2026 Notes: Online ahead of print.
162 Loaec M, Patterson E, Reeder R, Graham K, Donoghue M, Sawhney S, Pradhan A, Topjian AA, Sutton RM, Berg RA, Morgan RW.: Diastolic Blood Pressure During Pediatric In-Hospital Cardiac Arrest: Trends and Associations With Outcomes. Crit Care Med Mar 2026 Notes: online ahead of print.
148 Alcamo AM, Lieberman L, Sherry N, Ford HR, Fitzgerald JC, Topjian AA, Carcillo JA, Kochanek PM, Viaene AN, Aneja RK: Neuropathologic Autopsy Findings in Pediatric Sepsis: A Two-Center, Retrospective Study. Pediatr Crit Care Med 27(3): 253-263, March 2026.
13b Silva LEV, Balcarcel D, Ko TS, Morgan RW, Berg RA, Topjian A, Tsui FR, Kirschen MP: Prediction of neurological outcome after pediatric cardiac arrest using heart rate variability and machine learning. Resuscitation 219: 110961, February 2026.
17d Ullman NL, Reeder RW, Topjian A, Morgan RW, Berg RA, Nadkarni VM, Palmer CA, Sutton RM, Press CA, Kirschen MP; ICU-RESUS, CPCCRN Investigators: Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest. Resuscitation 218: 110886, January 2026.
16d Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo A, Huh JW, Lang S-S, Berg RA, Topjian AA, Press C, Kirschen MP: Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury. Neurocritical Care January 2026 Notes: Online ahead of print.
160 McSherry ML, Graham K, Woods-Hill CZ, Herrmann JR, Kirschen MP, Fowler JC, Gardner MM, Morgan RW, Sutton RM, Topjian A: Timing and mode of death after pediatric in- and out-of-hospital cardiac arrest: a single center retrospective study. Resuscitation 217: 110902, December 2025.
172 Shepard LN, Reeder RW, Hsu J, Keim G, Berg RA, Sutton RM, Topjian AA, Yehya N, Morgan RW; American Heart Association’s Get With The Guidelines–Resuscitation Investigators: Intubation Trends and Survival in Pediatric In-Hospital Cardiac Arrest. Jama Network Open 8(11): e2544365, November 2025.
162 Silva LEV, Chen CC, Press CA, Graham K, Shi L, Abend NS, Morgan RW, Topjian A, Tsui FR, Kirschen MP: Pediatric cardiac arrest outcome prediction using data-driven machine learning of early quantitative electroencephalogram (qEEG) features. Resuscitation 216: 110854, November 2025.
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Selected Publications
12f Loaec M, Vossough A, Francoeur C, Graham K, Morgan RW, Topjian AA, Kirschen MP: Spinal cord ischemia following pediatric cardiac arrest: An unexplored complication of hypoxic ischemic injury. J Clin Neurosci 147: 111916, May 2026.1bc Shepard LN, Napolitano N, Dominick C, Nickel AJ, Shults J, Laverriere McGovern E, Bruins BB, O'Halloran A, Huh J, Topjian A, Kirschen MP, Morgan RW, Sutton RM, Nadkarni VM, Nishisaki A: Quality of Bag-Mask Ventilation for Children Before Intubation: Single-Center PICU Pilot Observational Study, 2019–2022. Pediatr Crit Care Med March 2026 Notes: Online ahead of print.
162 Loaec M, Patterson E, Reeder R, Graham K, Donoghue M, Sawhney S, Pradhan A, Topjian AA, Sutton RM, Berg RA, Morgan RW.: Diastolic Blood Pressure During Pediatric In-Hospital Cardiac Arrest: Trends and Associations With Outcomes. Crit Care Med Mar 2026 Notes: online ahead of print.
148 Alcamo AM, Lieberman L, Sherry N, Ford HR, Fitzgerald JC, Topjian AA, Carcillo JA, Kochanek PM, Viaene AN, Aneja RK: Neuropathologic Autopsy Findings in Pediatric Sepsis: A Two-Center, Retrospective Study. Pediatr Crit Care Med 27(3): 253-263, March 2026.
13b Silva LEV, Balcarcel D, Ko TS, Morgan RW, Berg RA, Topjian A, Tsui FR, Kirschen MP: Prediction of neurological outcome after pediatric cardiac arrest using heart rate variability and machine learning. Resuscitation 219: 110961, February 2026.
17d Ullman NL, Reeder RW, Topjian A, Morgan RW, Berg RA, Nadkarni VM, Palmer CA, Sutton RM, Press CA, Kirschen MP; ICU-RESUS, CPCCRN Investigators: Severe intracranial hemorrhage or ischemia associated with unfavorable outcomes after pediatric in-hospital cardiac arrest. Resuscitation 218: 110886, January 2026.
16d Mazzio EL, Catenaccio E, Liu R, Vossough A, Abend NS, Alcamo A, Huh JW, Lang S-S, Berg RA, Topjian AA, Press C, Kirschen MP: Association of EEG Response to Hypertonic Saline and Neurologic Outcomes in Pediatric Acute Brain Injury. Neurocritical Care January 2026 Notes: Online ahead of print.
160 McSherry ML, Graham K, Woods-Hill CZ, Herrmann JR, Kirschen MP, Fowler JC, Gardner MM, Morgan RW, Sutton RM, Topjian A: Timing and mode of death after pediatric in- and out-of-hospital cardiac arrest: a single center retrospective study. Resuscitation 217: 110902, December 2025.
172 Shepard LN, Reeder RW, Hsu J, Keim G, Berg RA, Sutton RM, Topjian AA, Yehya N, Morgan RW; American Heart Association’s Get With The Guidelines–Resuscitation Investigators: Intubation Trends and Survival in Pediatric In-Hospital Cardiac Arrest. Jama Network Open 8(11): e2544365, November 2025.
162 Silva LEV, Chen CC, Press CA, Graham K, Shi L, Abend NS, Morgan RW, Topjian A, Tsui FR, Kirschen MP: Pediatric cardiac arrest outcome prediction using data-driven machine learning of early quantitative electroencephalogram (qEEG) features. Resuscitation 216: 110854, November 2025.
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