Alexis A. Topjian, MD, MSCE

faculty photo
Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
Fellowship Director, Neurocritical Care to Pediatric ICU, Children's Hospital of Philadelphia, Philadelphia, PA
Director, Pediatric Neurocritical Care Program, Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Director, Faculty Development, Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Department: Anesthesiology and Critical Care

Contact information
Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
BA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
Permanent link
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Selected Publications

Hickson MR, Winters M, Thomas NH, Gardner MM, Kirschen MP, Nadkarni V, Berg R, Slomine BS, Pinto NP, Topjian A: Long-term function, quality of life and healthcare utilization among survivors of pediatric out-of-hospital cardiac arrest. Resuscitation March 2023.

Fung FW, Parikh DS, Massey SL, Fitzgerald MP, Valva L, Donnelly M, Jacobwitz M, Kessler SK, Xiao R, Topjian AA, Nicholas S: Periodic Discharges in Critically Ill Children: Predictors and Outcome. Journal of Clinical Neurophyisology September 2022.

Kirschen MP, Berman JI, Liu H, Ouyang M, Mondal A, Griffis H, Levow C, Winters M, Lang SS, Huh J, Huang H, Berg RA, Vossough A, Topjian A: Association Between Quantitative Diffusion Weighted Magnetic Resonance Neuroimaging and Outcome After Pediatric Cardiac Arrest. Neurology August 2022.

Piantino JA, Ruzas CM, Press CA, Subramanian S, Balakrishnan B, Panigraphy A, Pettersson D, Maloney JA, Vossough A, Topjian A, Kirschen MP, Doughty L, Chung MG, Maloney D, Haller T, Fabio A, Fink EL, for the POCCA Investigators: Use of magnetic resonance imaging in neuroprognostication after pediatric cardiac arrest: Survey of current practices. Pediatric Neurology June 2022.

Becker AE, Teixeira SR, Lunig NA, Mondal A, Fitzgerald JC, Topjian AA, Weiss SL, Griffis H, Schramm SE, Traynor DM, Vossough A, Kirschen MP: Sepsis-Related Brain MRI Abnormalities Are Associated With Mortality and Poor Neurological Outcome in Pediatric Sepsis. Pediatric Neurology 128: 1-8, March 2022.

Francoeur C, Landis WP, Winters M, Naim MY, Donoghue A, Dominick CL, Huh JW, MacDonald JM, Lang SS, Yuan I, Berg RA, Nadkarni VM, Killbaugh TJ, Sutton RM, Kirschen MP, Morgan RW, Topjian AA: Near-infrared spectroscopy during cardiopulmonary resuscitation for pediatric cardiac arrest: a prospective, observational study. Resuscitation March 2022 Notes: epub ahead of print.

Kirschen M, Majmudar T, Diaz-Arrastia R, Berg R, Abella RS, Topjian A, Balu R: Deviations from PRx-derived optimal blood pressure are associated with mortality after cardiac arrest. Resuscitation March 2022 Notes: doi:

Gardner MM, Kirschen MP, Wong HR, McKeone DJ, Halstead ES, Thompson JM, Himebauch S, Topjian AA, Yehya N: Biomarkers Associated with Mortality in Pediatric Patients with Cardiac Arrest and Acute Respiratory Distress Syndrome. Resuscitation 170: 184-193, January 2022.

Fink EL, Robertson CL, Wainwright MS, Roa JD, Lovett ME, Stulce C, Yacoub M, Potera RM, Zivick E, Holloway A, Nagpal A, Wellnitz K, Czech T, Even KM, Brunow de Carvalho W, Rodriguez IS, Schwartz SP, Walker TC, Campos-Miño S, Dervan LA, Geneslaw AS, Sewell TB, Pryce P, Silver WG, Lin JE, Vargas WS, Topjian A, Alcamo AM, McGuire JL, Domínguez Rojas JA, Muñoz JT, Hong SJ, Muller WJ, Doerfler M, Williams CN, Drury K, Bhagat D, Nelson A, Price D, Dapul H, Santos L, Kahoud R, Francoeur C, Appavu B, Guilliams KP, Agner SC, Walson KH, Rasmussen L, Janas A, Ferrazzano P, Farias-Moeller R, Snooks KC, Chang CH, Yun J, Schober ME; Global Consortium Study of Neurologic Dysfunction in COVID-19 (GCS-NeuroCOVID) Investigators.: Prevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-C. Pediatric Neurology In Press 2022.

Erklauer JC, Thomas AX, Hong SJ, Appavu BL, Carpenter JL, Chiriboga-Salazar NR, Ferrazzano PA, Goldstein Z, Griffith JL, Guilliams KP, Kirschen MP, Lidsky K, Lovett ME, Mclaughlin B, Pareja JCM, Murphy S, O'Donnell W, Riviello JJ, Schober ME, Topjian AA, Wainwright MS, Simon DW: A Virtual Community of Practice: An International Educational Series in Pediatric Neurocritical Care. Children In Press 2022.

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Last updated: 03/31/2023
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