Alexis A. Topjian, MD, MSCE

faculty photo
Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Attending Physician, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Member, Medical Staff, Hospital of the University of Pennsylvania, Philadelphia, PA
Faculty Member, Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA
Director, Pediatric Neurocritical Care Program, Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Associate Chief, Faculty Affairs, Critical Care Medicine, Children's Hospital of Philadelphia
Associate Chair, Faculty Affairs, Children's Hospital of Philadephia
Department: Anesthesiology and Critical Care

Contact information
Children's Hospital of Philadelphia
Department of Anesthesia and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-3915
Fax: 215-590-4327
Education:
BA (Biology)
Harvard College, 1996.
MD (Medicine)
Columbia College of Physicians & Surgeons, 2001.
MSCE (Masters in Clinical Epidemiology and Biostatistics)
University of Pennsylvania School of Medicine, 2011.
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Selected Publications

Fung FW, Parikh DS, Donnelly M, Xiao R, Topjian AA, Abend NS: Electrographic Seizure Characteristics and Electrographic Status Epilepticus Prediction. Journal of Clinical Neurophysiology 42(1): 64-72, January 2025.

Kirschen MP, Ullman NL, Reeder RW, Ahmed T, Bell MJ, Berg RA, Burns C, Carcillo JA, Carpenter TC, Diddle J, Federman M, Fink EL, Frazier AH, Friess SH, Graham K, Horvat CM, Huard LL, Kilbaugh TJ, Maa T, Manga A, McQuillen PS, Meert KL, Morgan RW, Mourani PM, Nadkarni VM, Naim MY, Notterman D, Palmer CA, Pollack MM, Sapru A, Sharron MP, Srivastava N, Tilford B, Viteri S, Wolfe HA, Yates AR, Topjian A, Sutton RM, Press CA: Practice patterns for acquiring neuroimaging after pediatric in-hospital cardiac arrest. Resuscitation 207: 110506, January 2025.

VanBuren JM, Yeatts SD, Holubkov R, Moler FW, Topjian A, Page K, Clevenger RG, Meurer WJ: The Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP): Statistical Methods Planned in the Bayesian, Adaptive, Duration Finding Trial. Pediatric Critical Care Medicine Online ahead of print, December 2024.

Ushpol A, Je S, Christoff A, Nuthall G, Scholefield B, Morgan RW, Nadkarni V, Gangadharan S; pediRES-Q investigators: Evaluating post-cardiac arrest blood pressure thresholds associated with neurologic outcome in children: Insights from the pediRES-Q database. Resuscitation Online ahead of print, December 2024.

Gardner MM, Morgan RW, Reeder R, Ghaffari K, Ortmann L, Raymond T, Lasa JJ, Fowler J, Dewan M, Nadkarni VM, Berg R, Sutton R, Topjian AA, for the American Heart Association’s Get With The Guidelines, ®-Resuscitation Investigators: Trends in cardiac arrest outcomes & management in children with cardiac illness category compared to non-cardiac illness category: An analysis from the AHA Get With The Guidelines®-Resuscitation Registry. Resuscitation 205, December 2024.

Fowler JC, Morgan RW, O'Halloran A, Gardner MM, Appel S, Wolfe H, Kienzle MF, Raymond TT, Scholefield RB, Guerguerian A, Bembea MM, Nadkarni V, Berg RA, Topjian AA, American Heart Association’s Get With The Guidelines®-Resuscitation Investigators: The Impact of Pediatric Post-Cardiac Arrest Care on Survival: A Multicenter Review from the AHA Get With The Guidelines®-Resuscitation Post-Cardiac Arrest Care Registry. Resuscitation 202: 110301, September 2024 Notes: Multicenter Study.

O'Halloran A, Morgan RW, Kennedy K, Berg RA, Gathers CA, Naim MY, Nadkarni V, Reeder R, Topjian A, Wolfe H, Kleinman M, Chan PS, Sutton RM; American Heart Association’s Get With the Guidelines–Resuscitation Investigators: Characteristics of Pediatric In-Hospital Cardiac Arrests and Resuscitation Duration. JAMA Network Open 7(7): e2424670, July 2024.

O'Halloran AJ, Reeder RW, Berg RA, Ahmed T, Bell MJ, Bishop R, Bochkoris M, Burns C, Carcillo JA, Carpenter TC, Dean JM, Diddle JW, Federman M, Fernandez R, Fink EL, Franzon D, Frazier AH, Friess SH, Graham K, Hall M, Hehir DA, Horvat CM, Huard LL, Kienzle MF, Kilbaugh TJ, Maa T, Manga A, McQuillen PS, Meert KL, Mourani PM, Nadkarni VM, Naim MY, Notterman D, Pollack MM, Sapru A, Schneiter C, Sharron MP, Srivastava N, Tilford B, Topjian AA, Viteri S, Wessel D, Wolfe HA, Yates AR, Zuppa AF, Sutton RM, Morgan RW: Early bolus epinephrine administration during pediatric cardiopulmonary resuscitation for bradycardia with poor perfusion: an ICU-resuscitation study. Crit Care 28(1): 242, July 2024.

Francoeur C, Alcamo AM, Robertson CL, Wainwright MS, Roa JD, Lovett ME, Stulce C, Yacoub M, Potera RM, Zivick E, Holloway A, Nagpal A, Wellnitz K, Even KM, Brunow de Carvalho W, Rodriguez IS, Schwartz SP, Walker TC, Campos-Miño S, Dervan LA, Geneslaw AS, Sewell TB, Pryce P, Silver WG, Lin JE, Vargas WS, Topjian A, McGuire JL, Domínguez Rojas JA, Tasayco-Muñoz J, Hong SJ, Muller WJ, Doerfler M, Williams CN, Drury K, Bhagat D, Nelson A, Price D, Dapul H, Santos L, Kahoud R, Appavu B, Guilliams KP, Agner SC, Walson KH, Rasmussen L, Pal R, Janas A, Ferrazzano P, Farias-Moeller R, Snooks KC, Chang CH, Iolster T, Erklauer JC, Jorro Baron F, Wassmer E, Yoong M, Jardine M, Mohammad Z, Deep A, Kendirli T, Lidsky K, Dallefeld S, Flockton H, Agrawal S, Siruguppa KS, Waak M, Gutiérrez-Mata A, Butt W, Bogantes-Ledezma S, Sevilla-Acosta F, Umaña-Calderón A, Ulate-Campos A, Yock-Corrales A, Talisa VB, Kanthimathinathan HK, Schober ME, Fink EL: Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity. Jama Network Open 7(6): e2414122, June 2024.

Jacobwitz M, Mulvihill C, Kaufman MC, Gonzalez AK, Resendiz K, Francoeur C, Helbig I, Topjian AA, Abend NS: A Comparison of Ketamine Versus Midazolam as First-Line Anesthetic Infusions for Pediatric Status Epilepticus. Neurocritical Care 40(3): 984-995, June 2024.

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Last updated: 04/28/2025
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