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Debbie Cohen, MBBCH
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Professor of Medicine (Renal-Electrolyte and Hypertension) at the Hospital of the University of Pennsylvania
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Director of Hypertension Programs , Renal Division
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Director, Pheochromocytoma/Paraganglioma Program, Hospital of the University Of Pennsylvania
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Director of Clinical Research Renal Division, University of Pennsylvania
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Department: Medicine
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Contact information
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One Founders Pavilion
35 3400 Spruce Street
Philadelphia, PA 19104
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35 3400 Spruce Street
Philadelphia, PA 19104
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Office: 2156627544
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Email:
debbie.cohen@uphs.upenn.edu
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debbie.cohen@uphs.upenn.edu
Links
f9 Penn Kidney Medicine Comprehensive Hypertension Center (ASH-certified)
c5 Penn Medicine’s Neuroendocrine Tumor Program
121 Renal-Electrolyte and Hypertension Research Interests--Nephrology Clinical Research
135 Renal-Electrolyte and Hypertension Clinical Trials--Hypertension/SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED
de Penn's Renal-Electrolyte and Hypertension Division
ad Penn Kidney Medicine Dialysis Care
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f9 Penn Kidney Medicine Comprehensive Hypertension Center (ASH-certified)
c5 Penn Medicine’s Neuroendocrine Tumor Program
121 Renal-Electrolyte and Hypertension Research Interests--Nephrology Clinical Research
135 Renal-Electrolyte and Hypertension Clinical Trials--Hypertension/SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED
de Penn's Renal-Electrolyte and Hypertension Division
ad Penn Kidney Medicine Dialysis Care
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Education:
21 a MBBCH e ( ) c
50 University of Witwatersrand, Johannesburg, South Africa, 1990.
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Permanent link21 a MBBCH e ( ) c
50 University of Witwatersrand, Johannesburg, South Africa, 1990.
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Description of Research Expertise
64 complex hypertension, adrenal hypertension, pheochromocytoma, chronic kidney disease65
Description of Clinical Expertise
90 Chronic kidney disease, complex hypertension, pheochromocytoma,paraganglioma, adrenal hypertension and renovascular hypertension1a 29
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25e Dardari ZA, Yao Z, Zhang J, Bakoyannis G, Nan H, Staten LK, Jha KK, Tasdighi E, Jelwan Y, Burka S, Matsushita K, Simonsick EM, Lima JAC, Psaty BM, Cohen DL, Appel LJ, Khera A, Shah AM, Hall ME, Judd SE, Cole SA, Vasan RS, Benjamin EJ, Cawthon PM, Orwoll E, LaMonte MJ, Eaton CB, El Khoudary SR, Thurston RC, Derby CA, Lotufo PA, Bensenor IM, Bittencourt MS, Blaha MJ. : Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. Circulation. 153(10): 720-735, Mar 2026.
12f Sunderraj A, Cai X, Pasch A, Feinstein M, Mehta R, Srivastava A, Ricardo AC, Cohen DL, Isakova T. : Associations of calciprotein particle maturation time with echocardiographic measures in the CRIC Study. Am J Nephrol. Mar 2026.
1ac Estrada-Zuniga C, Liang R, Landry B, Alvarez A, Gonzalez-Cantu H, Nascimento da Conceição V, Trevino R, Gius D, Asa SL, Powers J, Prodanov T, Vaidya A, Toledo RA, Bayley JP, Cohen DL, Tischler AS, Pacak K, Li F, Dahia PLM.: Identifying TMEM127-deficient pheochromocytomas/paragangliomas via RET overexpression by immunohistochemistry. Res Sq Feb 2026.
1a9 Blinder AR, Sapiro D, Baker JE, Qin Z, Bancos I, Lyden ML, Young WF, Wachtel H, Cohen DL, Kürzinger L, Fassnacht M, Luther JM, Williams TA, Reincke M, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K. : Adrenal histologic and genetic characteristics of primary aldosteronism in late adulthood. Eur J Endocrinol. 194(2): 208-216, Feb 2026.
157 Pregnall AM, Wubbenhorst B, D'Andrea K, Pluta J, Amjad W, Shilan J, Cohen DL, Weathers B, Bennett B, Bonanni M, Montone K, Nathanson KL, Wachtel H.: Metastatic progression of pheochromocytoma and paraganglioma occurs via parallel evolution. NPJ Precis Oncol. Jan 2026.
1c0 White WB, Azizi M, Ferdinand K, Cohen DL, Nührenberg T, Lefkowitz M, Jiao R, Rizkala AR, Maboudian M, Williams B. : Natriuretic Peptide Receptor-1 Agonist for Resistant Hypertension: A Randomized Phase 2 Trial. J Am Coll Cardiol. 2026 Jan 13:S0735-1097(25)10351-3. doi: 10.1016/j.jacc.2025.11.045. Epub ahead of print. PMID: 41563174. S0735-1097(25): 10351-10353, Jan 2026.
24f Estrella MM, Ballew SH, Sang Y, Grams ME, Coresh J, Surapaneni A, Alencar de Pinho N, Ärnlöv J, Brenner H, Carrero JJ, Chen TK, Cohen DL, Cushman M, Gansevoort RT, Hwang SJ, Inker LA, Ix JH, Kabasawa K, Konta T, Lees JS, Polkinghorne KR, Shlipak MG, Vernooij RWM, Wheeler DC, Yadav AK, Levey AS, Eckardt KU; : Chronic Kidney Disease Prognosis Consortium Investigators and Collaborators. Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis. JAMA. 334(21): 1915-1926, Dec 2025.
2aa Tasdighi E, Yao Z, Dardari ZA, Jha KK, Osuji N, Rajan T, Boakye E, Matsushita K, Simonsick EM, Lima JAC, Lloyd-Jones DM, Cohen DL, Appel LJ, Khera A, Hall ME, Rodriguez CJ, Judd S, Cole SA, Ramachandran VS, Benjamin EJ, Lotufo PA, Bittencourt MS, El Khoudary SR, Thurston RC, Derby CA, Psaty BM, Eaton CB, LaMonte MJ, Cawthon PM, Orwoll ES, Bhatnagar A, DeFilippis AP, Blaha MJ. : Association between cigarette smoking status, intensity, and cessation duration with long-term incidence of nine cardiovascular and mortality outcomes: The Cross-Cohort Collaboration (CCC). PLoS Med. 22(11): e1004561, Nov 2025.
149 Shulman R, Yang W, Cohen DL, Reese PP, Cohen JB; CRIC Study Investigators. : Renin-Angiotensin System Inhibitors in Patients With Nonproteinuric Chronic Kidney Disease and Kidney Outcomes: Findings From the CRIC Study. Kidney Med. 8(1): 101159, Oct 2025.
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Selected Publications
1c1 Laffin LJ, Wang Q, Sarraju A, Touyz RM, Schlaich MP, Cohen DL, Mahfoud F, Mitchell LM, Mitchell J, Wolski K, Dennis P, Akere A, Li W, Chen G, Cohen YZ, Kim J, Cooper CG, Ramesan P, Edelberg JM, Nissen SE; : KARDINAL Investigators. Efficacy of Tonlamarsen in Patients With Uncontrolled Hypertension: The KARDINAL Phase 2 Randomized Clinical Trial. J Am Coll Cardiol. Mar 2026.25e Dardari ZA, Yao Z, Zhang J, Bakoyannis G, Nan H, Staten LK, Jha KK, Tasdighi E, Jelwan Y, Burka S, Matsushita K, Simonsick EM, Lima JAC, Psaty BM, Cohen DL, Appel LJ, Khera A, Shah AM, Hall ME, Judd SE, Cole SA, Vasan RS, Benjamin EJ, Cawthon PM, Orwoll E, LaMonte MJ, Eaton CB, El Khoudary SR, Thurston RC, Derby CA, Lotufo PA, Bensenor IM, Bittencourt MS, Blaha MJ. : Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. Circulation. 153(10): 720-735, Mar 2026.
12f Sunderraj A, Cai X, Pasch A, Feinstein M, Mehta R, Srivastava A, Ricardo AC, Cohen DL, Isakova T. : Associations of calciprotein particle maturation time with echocardiographic measures in the CRIC Study. Am J Nephrol. Mar 2026.
1ac Estrada-Zuniga C, Liang R, Landry B, Alvarez A, Gonzalez-Cantu H, Nascimento da Conceição V, Trevino R, Gius D, Asa SL, Powers J, Prodanov T, Vaidya A, Toledo RA, Bayley JP, Cohen DL, Tischler AS, Pacak K, Li F, Dahia PLM.: Identifying TMEM127-deficient pheochromocytomas/paragangliomas via RET overexpression by immunohistochemistry. Res Sq Feb 2026.
1a9 Blinder AR, Sapiro D, Baker JE, Qin Z, Bancos I, Lyden ML, Young WF, Wachtel H, Cohen DL, Kürzinger L, Fassnacht M, Luther JM, Williams TA, Reincke M, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K. : Adrenal histologic and genetic characteristics of primary aldosteronism in late adulthood. Eur J Endocrinol. 194(2): 208-216, Feb 2026.
157 Pregnall AM, Wubbenhorst B, D'Andrea K, Pluta J, Amjad W, Shilan J, Cohen DL, Weathers B, Bennett B, Bonanni M, Montone K, Nathanson KL, Wachtel H.: Metastatic progression of pheochromocytoma and paraganglioma occurs via parallel evolution. NPJ Precis Oncol. Jan 2026.
1c0 White WB, Azizi M, Ferdinand K, Cohen DL, Nührenberg T, Lefkowitz M, Jiao R, Rizkala AR, Maboudian M, Williams B. : Natriuretic Peptide Receptor-1 Agonist for Resistant Hypertension: A Randomized Phase 2 Trial. J Am Coll Cardiol. 2026 Jan 13:S0735-1097(25)10351-3. doi: 10.1016/j.jacc.2025.11.045. Epub ahead of print. PMID: 41563174. S0735-1097(25): 10351-10353, Jan 2026.
24f Estrella MM, Ballew SH, Sang Y, Grams ME, Coresh J, Surapaneni A, Alencar de Pinho N, Ärnlöv J, Brenner H, Carrero JJ, Chen TK, Cohen DL, Cushman M, Gansevoort RT, Hwang SJ, Inker LA, Ix JH, Kabasawa K, Konta T, Lees JS, Polkinghorne KR, Shlipak MG, Vernooij RWM, Wheeler DC, Yadav AK, Levey AS, Eckardt KU; : Chronic Kidney Disease Prognosis Consortium Investigators and Collaborators. Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis. JAMA. 334(21): 1915-1926, Dec 2025.
2aa Tasdighi E, Yao Z, Dardari ZA, Jha KK, Osuji N, Rajan T, Boakye E, Matsushita K, Simonsick EM, Lima JAC, Lloyd-Jones DM, Cohen DL, Appel LJ, Khera A, Hall ME, Rodriguez CJ, Judd S, Cole SA, Ramachandran VS, Benjamin EJ, Lotufo PA, Bittencourt MS, El Khoudary SR, Thurston RC, Derby CA, Psaty BM, Eaton CB, LaMonte MJ, Cawthon PM, Orwoll ES, Bhatnagar A, DeFilippis AP, Blaha MJ. : Association between cigarette smoking status, intensity, and cessation duration with long-term incidence of nine cardiovascular and mortality outcomes: The Cross-Cohort Collaboration (CCC). PLoS Med. 22(11): e1004561, Nov 2025.
149 Shulman R, Yang W, Cohen DL, Reese PP, Cohen JB; CRIC Study Investigators. : Renin-Angiotensin System Inhibitors in Patients With Nonproteinuric Chronic Kidney Disease and Kidney Outcomes: Findings From the CRIC Study. Kidney Med. 8(1): 101159, Oct 2025.
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