Debbie Cohen, MBBCH
Professor of Medicine (Renal-Electrolyte and Hypertension) at the Hospital of the University of Pennsylvania
Director of Hypertension Programs , Renal Division
Director, Pheochromocytoma/Paraganglioma Program, Hospital of the University Of Pennsylvania
Director of Clinical Research Renal Division, University of Pennsylvania
Department: Medicine
Contact information
One Founders Pavilion
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Office: 2156627544
Email:
debbie.cohen@uphs.upenn.edu
debbie.cohen@uphs.upenn.edu
Links
Penn Kidney Medicine Comprehensive Hypertension Center (ASH-certified)
Renal-Electrolyte and Hypertension Research Interests--Nephrology Clinical Research
Penn Medicine’s Neuroendocrine Tumor Program
Renal-Electrolyte and Hypertension Clinical Trials--Hypertension/SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED
Penn's Renal-Electrolyte and Hypertension Division
Penn Kidney Medicine Dialysis Care
Penn Kidney Medicine Comprehensive Hypertension Center (ASH-certified)
Renal-Electrolyte and Hypertension Research Interests--Nephrology Clinical Research
Penn Medicine’s Neuroendocrine Tumor Program
Renal-Electrolyte and Hypertension Clinical Trials--Hypertension/SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED
Penn's Renal-Electrolyte and Hypertension Division
Penn Kidney Medicine Dialysis Care
Education:
MBBCH ( )
University of Witwatersrand, Johannesburg, South Africa, 1990.
Permanent linkMBBCH ( )
University of Witwatersrand, Johannesburg, South Africa, 1990.
Description of Research Expertise
complex hypertension, adrenal hypertension, pheochromocytoma, chronic kidney diseaseDescription of Clinical Expertise
Chronic kidney disease, complex hypertension, pheochromocytoma,paraganglioma, adrenal hypertension and renovascular hypertensionSelected Publications
Blinder AR, Sapiro D, Baker JE, Qin Z, Bancos I, Lyden ML, Young WF, Wachtel H, Cohen DL, Kürzinger L, Fassnacht M, Luther JM, Williams TA, Reincke M, Turcu AF, Else T, Giordano TJ, Udager AM, Rainey WE, Nanba K. : Adrenal histologic and genetic characteristics of primary aldosteronism in late adulthood. Eur J Endocrinol. Jan 2026.White WB, Azizi M, Ferdinand K, Cohen DL, Nührenberg T, Lefkowitz M, Jiao R, Rizkala AR, Maboudian M, Williams B. : Natriuretic Peptide Receptor-1 Agonist for Resistant Hypertension: A Randomized Phase 2 Trial. J Am Coll Cardiol. 2026 Jan 13:S0735-1097(25)10351-3. doi: 10.1016/j.jacc.2025.11.045. Epub ahead of print. PMID: 41563174. S0735-1097(25): 10351-10353, Jan 2026.
Pregnall AM, Wubbenhorst B, D'Andrea K, Pluta J, Amjad W, Shilan J, Cohen DL, Weathers B, Bennett B, Bonanni M, Montone K, Nathanson KL, Wachtel H.: Metastatic progression of pheochromocytoma and paraganglioma occurs via parallel evolution. NPJ Precis Oncol. Jan 2026.
Estrella MM, Ballew SH, Sang Y, Grams ME, Coresh J, Surapaneni A, Alencar de Pinho N, Ärnlöv J, Brenner H, Carrero JJ, Chen TK, Cohen DL, Cushman M, Gansevoort RT, Hwang SJ, Inker LA, Ix JH, Kabasawa K, Konta T, Lees JS, Polkinghorne KR, Shlipak MG, Vernooij RWM, Wheeler DC, Yadav AK, Levey AS, Eckardt KU; : Chronic Kidney Disease Prognosis Consortium Investigators and Collaborators. Discordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis. JAMA. 334(21): 1915-1926, Dec 2025.
Tasdighi E, Yao Z, Dardari ZA, Jha KK, Osuji N, Rajan T, Boakye E, Matsushita K, Simonsick EM, Lima JAC, Lloyd-Jones DM, Cohen DL, Appel LJ, Khera A, Hall ME, Rodriguez CJ, Judd S, Cole SA, Ramachandran VS, Benjamin EJ, Lotufo PA, Bittencourt MS, El Khoudary SR, Thurston RC, Derby CA, Psaty BM, Eaton CB, LaMonte MJ, Cawthon PM, Orwoll ES, Bhatnagar A, DeFilippis AP, Blaha MJ. : Association between cigarette smoking status, intensity, and cessation duration with long-term incidence of nine cardiovascular and mortality outcomes: The Cross-Cohort Collaboration (CCC). PLoS Med. 22(11): e1004561, Nov 2025.
Shulman R, Yang W, Cohen DL, Reese PP, Cohen JB; CRIC Study Investigators. : Renin-Angiotensin System Inhibitors in Patients With Nonproteinuric Chronic Kidney Disease and Kidney Outcomes: Findings From the CRIC Study. Kidney Med. 8(1): 101159, Oct 2025.
van Rooyen D, Bandulik S, Coon GA, Laukemper M, Kumar-Sinha C, Udager AM, Lerario AM, Lee C, Wachtel H, Cohen DL, Luther JM, Giordano TJ, Scholl UI, Butz F, Popp B, Turcu AF, Warth R, Rainey WE, Rege J.: Somatic Mutations in MCOLN3 Are Associated With Aldosterone-Producing Adenomas. Hypertension. Aug 2025.
Byfield RL, Zhang R, Cohen DL, Townsend R, Hossain A, Shimbo D, Cohen JB; CRIC Study Investigators. : Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort. Am J Hypertens Jun 2025.
McCoy IE, Yang J, Go AS, Rincon-Choles H, Taliercio J, Rosas SE, Unruh M, Shah V, Cohen DL, He J, Chen J, Sondheimer J, Parsa A, Yang W, Rao PS, Hsu CY; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. : Complex Etiologies of the Discordance Between Cystatin C- and Creatinine-Based Estimated GFR and Its Adverse Associations: Findings From the CRIC Study. Am J Kidney Dis 13, May 2025.
Laffin LJ, Kopjar B, Melgaard C, Wolski K, Ibbitson J, Bhikam S, Weir MR, Ofili EO, Mehra R, Luther JM, Cohen DL, Sarraju A, Wilkinson MJ, Flack JM, Rodman D, Nissen SE; Advance-HTN Investigators.: Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension. N Engl J Med. 392(18): 1813-1823, May 2025.