Kevin J Downes, MD
Assistant Professor of Pediatrics (Infectious Diseases) at the Children's Hospital of Philadelphia
Faculty member, Clinical Futures, Children's Hospital of Philadelphia
Clinical Director of Solid Organ Transplant Infectious Diseases, Division of Infectious Diseases, Children's Hospital of Philadelphia
Associate Director, Small Molecules & Metabolites Core Laboratory, Children's Hospital of Philadelphia Research Institute
Co-Director, Clinical Pharmacology Research Affinity Group, Children's Hospital of Philadelphia
Mechanisms of Disease & Therapeutic Intervention (MDTI) Clinical Pharmacology Course Director, Perelman School of Medicine of the University of Pennsylvania
Department: Pediatrics
Contact information
Division of Infectious Diseases
Children's Hospital of Philadelphia
2716 South Street, Suite 10360
Philadelphia, PA 19146
Children's Hospital of Philadelphia
2716 South Street, Suite 10360
Philadelphia, PA 19146
Office: 2155904024
Email:
downeskj@chop.edu
downeskj@chop.edu
Publications
Education:
BA
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Permanent linkBA
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Description of Clinical Expertise
Pediatric Infectious DiseasesTransplant Infectious Diseases
Description of Research Expertise
Antimicrobial pharmacokinetics/pharmacodynamicsAcute kidney injury
Pharmacoepidemiology
Clinical research
Solid organ transplant infectious diseases
Therapeutic drug monitoring
Selected Publications
Meesters K, Balbas-Martinez V, Allegaert K, Downes KJ, Michelet R.: Personalized Dosing of Medicines for Children: A Primer on Pediatric Pharmacometrics for Clinicians. Paediatr Drugs May 2024.Stitt G, Spinella PC, Bochicchio GV, Roberts I, Downes KJ, Zuppa AF: Population pharmacokinetic modelling and simulation of tranexamic acid in adult trauma patients. Br J Clin Pharmacol May 2024.
Morales Junior R, Amajor V, Paice K, Kyler KE, Hambrick HR, Pavia KE, Haynes AS, Gooden F, Pais GM, Downes KJ, Ramsey LB, Wagner J, Tang Girdwood S: From Dose to Exposure: Shifting the Paradigm of Pediatric Clinical Pharmacology Research and Education. Clin Pharmacol Ther Apr 2024.
Valencia Deray KG, Danziger-Isakov LA, Downes KJ.: Current and Emerging Antiviral Agents in the Prevention and Treatment of Cytomegalovirus in Pediatric Transplant Recipients. J Pediatric Infect Dis Soc. 13; Supplement, Feb 2024.
Takyi-Williams J, Leino AD, Li R, Downes KJ, Zuppa AF, Bwint A, Wen B, Sun D, Scheetz MH, Pai MP: Bioanalysis of Six Antibiotics from Volumetric Microsamples: A New Tool for Precision Dosing in Critically Ill Children. Bioanalysis 16(1): 19-31, Jan 2024.
Jorger T, Hayes M, Stinson C, Mikhail I, Downes KJ: Incidence of Antimicrobial Associated Acute Kidney Injury in Children: A Structured Review. Pediatr Drugs 26(1): 59-70, Jan 2024.
Coggins SA, Mukhopadhyay S, Triebwasser J, Downes KJ, Christie JD, Puopolo KM: Association of delivery risk phenotype with early-onset sepsis in preterm infants. J Perinatol 43(9): 1166-1172, Sept 2023.
Hong LT, Downes KJ, FakhriRavari A, Abdul-Mutakabbir JC, Kuti JL, Jorgensen S, Young DC, Alshaer MH, Bassetti M, Bonomo RA, Gilchrist M, Jang SM, Lodise T, Roberts JA, Tängdén T, Zuppa A, Scheetz MH: International consensus recommendations for the use of prolonged-infusion beta-lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists: An executive summary. Pharmacotherapy 43(8): 736-739, Aug 2023.
Zaoutis T, Shaikh N, Fisher BT, Coffin SE, Bhatnagar S, Downes KJ, Gerber JS, Shope TR, Martin JM, Muniz GB, Green M, Nagg JP, Myers SR, Mistry RD, O'Connor S, Faig W, Black S, Rowley E, Liston K, Hoberman A. : Short-Course Therapy for Urinary Tract Infections in Children: The SCOUT Randomized Clinical Trial. JAMA Pediatr Jun 2023.
Downes KJ, Zuppa AF, Sharova A, Neely MN: Optimizing Vancomycin Therapy in Critically Ill Children: A Population Pharmacokinetics Study to Inform Vancomycin Area under the Curve Estimation Using Novel Biomarkers. Pharmaceutics 15(5): 1336, Apr 2023.