Kevin J Downes, MD
Assistant Professor of Pediatrics (Infectious Diseases) at the Children's Hospital of Philadelphia
Faculty, Clinical Futures, Children's Hospital of Philadelphia
Clinical Director of Solid Organ Transplant Infectious Diseases, Division of Infectious Diseases, CHOP
Program Director, Clinical Pharmacology T32 Training Program, CHOP
Associate Director, Small Molecules & Metabolites Core Laboratory, CHOP
Faculty, Center for the Study of Antimicrobial Resistance, University of Pennsylvania
Director, Center for Pediatric Clinical and Translational Pharmacology Research, CHOP
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Infectious Diseases
2716 South Street, Suite 10360
Philadelphia, PA 19146
Division of Infectious Diseases
2716 South Street, Suite 10360
Philadelphia, PA 19146
Office: 2155904024
Email:
downeskj@chop.edu
downeskj@chop.edu
Publications
Education:
BA (Law, Jurisprudence & Social Thought)
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Permanent linkBA (Law, Jurisprudence & Social Thought)
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Description of Clinical Expertise
Pediatric Infectious DiseasesTransplant Infectious Diseases
Description of Research Expertise
Antimicrobial pharmacokinetics/pharmacodynamicsAcute kidney injury
Pharmacoepidemiology
Clinical research
Solid organ transplant infectious diseases
Therapeutic drug monitoring
Selected Publications
Nguyen MT, Neely MN, Åsberg A, Boge CLK, Downes KJ: A Matched Case-Control Study to Evaluate Predicted Drug Exposures and Neutropenia during Valganciclovir Prophylaxis in Pediatric Solid Organ Transplant Recipients. Transpl Infect Dis e70146, Dec 2025.Coggns SA, Wade KC, Downes KJ: Advances in Pediatric Therapeutic Drug Monitoring. Pediatrics Page: e2025073013, Dec 2025.
Liversedge M, Wang J, Boustany M, Sharova A, Lin KY, O’Connor MJ, Danziger-Isakov LA, Ryan TD, Downes KJ, Otto WR.: Epidemiology of Invasive Fungal Disease in Pediatric Heart Transplant Recipients. Jour Pediatr Infect Dis Soc piaf101, Nov 2025.
Nguyen UM, Neely M, Asberg A, Downes KJ: Comparing Valganciclovir Exposures to Predict Neutropenia in Pediatric Solid Organ Transplant Recipients. IDWeek 2025, Atlanta, GA, Poster Oct 2025.
Shiau J, Amajor V, Marianski S, Bwint A, Sharova A, Rhodes NJ, Zuppa A, Hall M, Pai M, Wen B, Downes KJ, Scheetz MH, PALISI Study Investigators : Vancomycin Population Pharmacokinetics and Toxicity-Exposure Relationships in Children with Multiple Organ Dysfunction Syndrome. IDWeek 2025, Atlanta, GA, Poster Oct 2025.
Marianski S, Amajor V, Shiau J, Bwint A, Sharova A, Hall M, Zuppa A, Rhodes NJ, Downes KJ, Scheetz M, PALISI Study Investigators : Evaluation of Ceftriaxone Population Pharmacokinetics (PK) and Pharmacodynamics (PD) in Critically Ill Pediatric Population. IDWeek 2025, Atlanta, GA, Poster Oct 2025.
Searns JB, Hall M, Birkholz M, Downes KJ, Hubbell BB, Kern-Goldberger AS, Markham JL, Newland JG, Rolsma SL, Wang ME, O'Leary ST, Dominguez SR, Parker SK, Kronman MP: Accuracy of pathogen diagnostic codes for acute hematogenous musculoskeletal infections in children. J Hosp Med 20(8): 853-857, Aug 2025.
Downes KJ, Danziger-Isakov L, Varela-Fascinetto G, Herold BC, Green M, L’Huillier AG: Debates in management and treatment of CMV in pediatric solid organ transplant recipients: a case-based discussion. Pediatr Transplant 29(5): e70135, Aug 2025.
Bamat NA, Huber M, DeMauro SB, Feng R, Fitzgerald JC, Feudtner C, Nelin TD, Downes KJ: Changes in diuretic response to furosemide during postnatal maturation in very preterm infants. American Thoracic Society Meeting, San Francisco, CA, Poster May 2025.
Downes KJ, Sharova A, Malone J, Odom John AR, Zuppa AF, Neely MN: Multiple Model Optimal Sampling Promotes Accurate Vancomycin Area-Under-the-Curve Estimation Using a Single Sample in Critically Ill Children. Ther Drug Monit 47(4): 512-519, May 2025.