Kevin J Downes, MD
Assistant Professor of Pediatrics (Infectious Diseases) at the Children's Hospital of Philadelphia
Faculty, Clinical Futures, Children's Hospital of Philadelphia
Clinical Director of Solid Organ Transplant Infectious Diseases, Division of Infectious Diseases, Children's Hospital of Philadelphia
Program Director, Clinical Pharmacology T32 Training Program, Children's Hospital of Philadelphia
Associate Director, Small Molecules & Metabolites Core Laboratory, Children's Hospital of Philadelphia Research Institute
Co-Director, Clinical Pharmacology Research Affinity Group, Children's Hospital of Philadelphia
Faculty, Center for the Study of Antimicrobial Resistance, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Infectious Diseases
2716 South Street, Suite 10360
Philadelphia, PA 19146
Division of Infectious Diseases
2716 South Street, Suite 10360
Philadelphia, PA 19146
Office: 2155904024
Email:
downeskj@chop.edu
downeskj@chop.edu
Publications
Education:
BA (Law, Jurisprudence & Social Thought)
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Permanent linkBA (Law, Jurisprudence & Social Thought)
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Description of Clinical Expertise
Pediatric Infectious DiseasesTransplant Infectious Diseases
Description of Research Expertise
Antimicrobial pharmacokinetics/pharmacodynamicsAcute kidney injury
Pharmacoepidemiology
Clinical research
Solid organ transplant infectious diseases
Therapeutic drug monitoring
Selected Publications
Bamat NA, Huber M, DeMauro SB, Feng R, Fitzgerald JC, Feudtner C, Nelin TD, Downes KJ: Changes in diuretic response to furosemide during postnatal maturation in very preterm infants. American Thoracic Society Meeting, San Francisco, CA, Poster May 2025.Hewlett JL, Goka S, Nwaogazie U, Finkel R, Galea L, Lopez S, Laskin B, LaRosa C, Downes KJ, Amaral S, Savant JD, Viteri B.: A Case Report of Successful Use of Phenytoin/Fosphenytoin in a Pediatric Kidney Transplant Recipient With Nirmatrelvir/Ritonavir-Induced Tacrolimus Allograft Injury. Pediatr Transplant 29(3), May 2025.
Kotton CN, Kumar D, Manuel O, Chou S, Hayden RT, Danziger-Isakov L, Asberg A, Tedesco-Silva H, Humar A; Transplantation Society International CMV Consensus Group.: The Fourth International Consensus Guidelines on the Management of Cytomegalovirus in Solid Organ Transplantation. Transplantation Apr 2025.
Coggins SA, Wade KC, Watt KM, Downes KJ, Puopolo KM.: Vancomycin Concentrations in Umbilical Cord Blood After Intrapartum Exposure. Obstet Gynecol 145(4), Apr 2025.
Searns JB, Hall M, Birkholz M, Downes KJ, Hubbell BB, Kern-Goldberger AS, Markham JL, Newland JG, Rolsma SL, Wang ME, O'Leary ST, Dominguez SR, Parker SK, Kronman MP: Accuracy of pathogen diagnostic codes for acute hematogenous musculoskeletal infections in children. J Hosp Med Page: doi: 10.1002, Mar 2025 Notes: epub ahead of print.
Downes KJ, Sharova A, Amajor V, Gianchetti L, Himebauch AS, Fitzgerald JC, Zuppa AF: Urinary Biomarkers and Attainment of Cefepime Therapeutic Targets in Critically Ill Children. Pediatr Infect Dis J Mar 2025.
Downes KJ, Sharova A, Malone J, Odom John AR, Zuppa AF, Neely MN: Multiple Model Optimal Sampling Promotes Accurate Vancomycin Area-Under-the-Curve Estimation Using a Single Sample in Critically Ill Children. Ther Drug Monit Page: doi: 10.1097, Mar 2025 Notes: epub ahead of print.
Bamat NA, Huber M, DeMauro SB, Feng R, Fitzgerald JC, Feudtner C, Nelin TD, Downes KJ: Changes in diuretic response to furosemide during postnatal maturation in very preterm infants. Eastern Society for Pediatric Research, Philadelphia PA, Podium Mar 2025.
Coggins SA, Wade KC, Watt KM, Downes KJ, Puopolo KM.: Umbilical cord blood gentamicin concentrations following maternally-administered intrapartum exposures. Pediatr Res Page: doi: 10.1038, Mar 2025 Notes: epub ahead of print.
Downes KJ, Alemayehu T, Ashkenazi-Hoffnung L: ID Consultant: Laboratory monitoring during long-term use of oral antimicrobials in pediatric patients. J Pediatric Infect Dis Soc 13(10): 551-560, Nov 2024.