Kevin J Downes, MD
Assistant Professor of Pediatrics (Infectious Diseases) at the Children's Hospital of Philadelphia
Faculty member, Clinical Futures, Children's Hospital of Philadelphia
Clinical Director of Solid Organ Transplant Infectious Diseases, Division of Infectious Diseases, Children's Hospital of Philadelphia
Associate Director, Small Molecules & Metabolites Core Laboratory, Children's Hospital of Philadelphia Research Institute
Co-Director, Clinical Pharmacology Research Affinity Group, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Division of Infectious Diseases
Children's Hospital of Philadelphia
2716 South Street, Suite 10360
Philadelphia, PA 19146
Children's Hospital of Philadelphia
2716 South Street, Suite 10360
Philadelphia, PA 19146
Office: 2155904024
Email:
downeskj@chop.edu
downeskj@chop.edu
Publications
Education:
BA
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Permanent linkBA
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Description of Clinical Expertise
Pediatric Infectious DiseasesTransplant Infectious Diseases
Description of Research Expertise
Antimicrobial pharmacokinetics/pharmacodynamicsAcute kidney injury
Pharmacoepidemiology
Clinical research
Solid organ transplant infectious diseases
Therapeutic drug monitoring
Selected Publications
Coggins SA, Mukhopadhyay S, Triebwasser J, Downes KJ, Christie JD, Puopolo KM: Association of delivery risk phenotype with early-onset sepsis in preterm infants. J Perinatol 43(9): 1166-1172, Sept 2023.Coggins SA, Mukhopadhyay S, Triebwasser J, Downes KJ, Christie JD, Puopolo KM.: Association of delivery risk phenotype with early-onset sepsis in preterm infants. J Perinatal 43(9): 1166-1172, Sep 2023.
Hong LT, Downes KJ, FakhriRavari A, Abdul-Mutakabbir JC, Kuti JL, Jorgensen S, Young DC, Alshaer MH, Bassetti M, Bonomo RA, Gilchrist M, Jang SM, Lodise T, Roberts JA, Tängdén T, Zuppa A, Scheetz MH: International consensus recommendations for the use of prolonged-infusion beta-lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists: An executive summary. Pharmacotherapy 43(8): 736-739, Aug 2023.
Hong LT, Downes KJ, FakhriRavari A, Abdul-Mutakabbir JC, Kuti JL, Jorgensen S, Young DC, Alshaer MH, Bassetti M, Bonomo RA, Gilchrist M, Jang SM, Lodise T, Roberts JA, Tängdén T, Zuppa A, Scheetz MH.: International consensus recommendations for the use of prolonged-infusion beta-lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists. Pharmacotherapy 43(8): 740-777, Aug 2023.
Zaoutis T, Shaikh N, Fisher BT, Coffin SE, Bhatnagar S, Downes KJ, Gerber JS, Shope TR, Martin JM, Muniz GB, Green M, Nagg JP, Myers SR, Mistry RD, O'Connor S, Faig W, Black S, Rowley E, Liston K, Hoberman A. : Short-Course Therapy for Urinary Tract Infections in Children: The SCOUT Randomized Clinical Trial. JAMA Pediatr Jun 2023.
Downes KJ, Zuppa AF, Sharova A, Neely MN: Optimizing Vancomycin Therapy in Critically Ill Children: A Population Pharmacokinetics Study to Inform Vancomycin Area under the Curve Estimation Using Novel Biomarkers. Pharmaceutics 15(5): 1336, Apr 2023.
Searns JB, Rice JD, Bertin KB, Birkholz M, Barganier LB, Creech CB, Downes KJ, Hubbell BB, Kronman MP, Rolsma SL, Sydney GI, O'Leary ST, Parker SK, Dominguez SR.: Using Administrative Billing Codes to Identify Acute Musculoskeletal Infections in Children. Hosp Pediatr 13(2): 182-195, Feb 2023.
Westling T, Downes KJ, Small DSS: Nonparametric Maximum Likelihood Estimation Under a Likelihood Ratio Order. Statistica Sinica 33: 1-19, 2023.
Meesters K, Alemayehu T, Benou S, Buonsenso D, Decloedt EH, Pillay-Fuentes Lorente V, Downes KJ, Allegaert K: Pharmacokinetics of Antimicrobials in Children with Emphasis on Challenges Faced by Low and Middle Income Countries, a Clinical Review. Antibiotics 12(1), 2023.
Downes KJ, Stitt G, Zuppa AF: Pharmacology. Rogers’ Textbook of Pediatric Intensive Care, 6th edition. Wolters Kluwer, 2023.