Kevin J Downes, MD
Assistant Professor of Pediatrics (Infectious Diseases) at the Children's Hospital of Philadelphia
Faculty, Clinical Futures, Children's Hospital of Philadelphia
Clinical Director of Solid Organ Transplant Infectious Diseases, Division of Infectious Diseases, CHOP
Program Director, Clinical Pharmacology T32 Training Program, CHOP
Associate Director, Small Molecules & Metabolites Core Laboratory, CHOP
Faculty, Center for the Study of Antimicrobial Resistance, University of Pennsylvania
Director, Pediatric Clinical and Translational Pharmacology Research Center, CHOP
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Infectious Diseases
2716 South Street, Suite 10360
Philadelphia, PA 19146
Division of Infectious Diseases
2716 South Street, Suite 10360
Philadelphia, PA 19146
Office: 2155904024
Email:
downeskj@chop.edu
downeskj@chop.edu
Publications
Education:
BA (Law, Jurisprudence & Social Thought)
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Permanent linkBA (Law, Jurisprudence & Social Thought)
Amherst College, 2001.
MD
University of Pennsylvania School of Medicine, 2008.
Description of Clinical Expertise
Pediatric Infectious DiseasesTransplant Infectious Diseases
Description of Research Expertise
Antimicrobial pharmacokinetics/pharmacodynamicsAcute kidney injury
Pharmacoepidemiology
Clinical research
Solid organ transplant infectious diseases
Therapeutic drug monitoring
Selected Publications
Alghanem SS, Downes KJ, Desai A, Avedissian SN, Awad AI: Awareness, Use, Attitudes, and Implementation Challenges of Bayesian Dose Prediction Software in Clinical Practice: A Multi-Organizational Survey. Frontiers in Pharmacology 2026 (Accepted).Nicolas Bamat, Matthew Huber, Heidi Morris, Timothy Nelin, Kevin Downes, Anna O'Brien, Benjamin Laskin, Erik Jensen, Sara DeMauro, Eric Eichenwald, Scott Lorch: Association between route of furosemide administration and diuretic response in very preterm infants with bronchopulmonary dysplasia. Journal of Perinatology 2026 (Accepted).
Vader DT, Shu D, Hubbard RA, Boge C, Sharova A, Downes K, Li Y: Informed presence in electronic health record data: illustrating bias and bias reduction approaches in longitudinal analyses. Epidemiology Mar 2026.
Coggns SA, Wade KC, Downes KJ: Advances in Pediatric Therapeutic Drug Monitoring. Pediatrics 157(1): e2025073013, Jan 2026.
Downes KJ: Tularemia (Francisella tularensis). Nelson Textbook of Pediatrics. Robert M. Kliegman, Joseph W. St. Geme, III (eds.). Elsevier, 2026 Notes: Chapter.
Downes KJ: Brucella. Nelson Textbook of Pediatrics. Robert M. Kliegman, Joseph W. St. Geme, III (eds.). Elsevier, 2026 Notes: Chapter.
Nguyen MT, Neely MN, Åsberg A, Boge CLK, Downes KJ: A Matched Case-Control Study to Evaluate Predicted Drug Exposures and Neutropenia during Valganciclovir Prophylaxis in Pediatric Solid Organ Transplant Recipients. Transpl Infect Dis e70146, Dec 2025.
Liversedge M, Wang J, Boustany M, Sharova A, Lin KY, O’Connor MJ, Danziger-Isakov LA, Ryan TD, Downes KJ, Otto WR.: Epidemiology of Invasive Fungal Disease in Pediatric Heart Transplant Recipients. Jour Pediatr Infect Dis Soc piaf101, Nov 2025.
Nguyen UM, Neely M, Asberg A, Downes KJ: Comparing Valganciclovir Exposures to Predict Neutropenia in Pediatric Solid Organ Transplant Recipients. IDWeek 2025, Atlanta, GA, Poster Oct 2025.
Marianski S, Amajor V, Shiau J, Bwint A, Sharova A, Hall M, Zuppa A, Rhodes NJ, Downes KJ, Scheetz M, PALISI Study Investigators : Evaluation of Ceftriaxone Population Pharmacokinetics (PK) and Pharmacodynamics (PD) in Critically Ill Pediatric Population. IDWeek 2025, Atlanta, GA, Poster Oct 2025.