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Brenda Barber Hoffman, MD
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Professor of Clinical Medicine (Renal-Electrolyte and Hypertension)
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Medical Director, Acute Dialysis Program, Penn Presbyterian Medical Center,Philadelphia, PA
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Department: Medicine
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Contact information
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240 Medical Office Building
28 Penn Presbyterian Medical Center
37 39th & Market Street
Philadelphia, PA 19104
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28 Penn Presbyterian Medical Center
37 39th & Market Street
Philadelphia, PA 19104
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Office: 215-662-8730
32 Fax: 215-243-4686
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32 Fax: 215-243-4686
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Links
ae Penn Kidney Medicine Dialysis Care
de Penn's Renal-Electrolyte and Hypertension Division
ba Penn Presbyterian Medical Center
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ae Penn Kidney Medicine Dialysis Care
de Penn's Renal-Electrolyte and Hypertension Division
ba Penn Presbyterian Medical Center
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Education:
21 9 B.A. 14 (Biology) c
36 Franklin and Marshall College, 1985.
21 9 M.D. c
33 University of Pennsylvania, 1989.
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Permanent link21 9 B.A. 14 (Biology) c
36 Franklin and Marshall College, 1985.
21 9 M.D. c
33 University of Pennsylvania, 1989.
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Description of Clinical Expertise
a0 Chronic kidney disease, Acute kidney injury, In center hemodialysis, Peritoneal dialysis, Acute dialysis, Kidney stones, Diabetic kidney disease1a 29
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105 Barbieri J, Seshasai R, Shemash A, Sedrak M, Hoffman B, Alley E: Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. Journal of Thoracic Oncology 8(6): e57-8, June 2013.
f0 Tan A, Hoffman B, Rosas SE: Patient perception of risk factors associated with chronic kidney disease morbidity and mortality. Ethnicity and Disease 20: 106-108, 2010.
52 Hoffman BB: Peritoneal Dialysis 2 2 2 2 2 2 2 2 2 2 8f Current Diagnosis and Treatment in Nephrology and Hypertension. McGraw-Hill, Chapter 51(Section 8): 444-452, Jan 2009.
e1 Hoffman BB: Surgery in the Patient with Kidney Disease. Medical Management of the Surgical Patient 3rd edition. Elsevier, Chapter 18: 605-632, Feb 2008.
111 Chen S, Hoffman BB, Jim B, Lee JS, Kopp JB, Ziyadeh FN: Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose. Kidney Intl 65: 1191-1204, 2004.
102 Chen S, Lee JS, Hoffman BB, Ziyadeh FN: Cultured tubule cells from TGF-beta 1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose JASN 14: 128A, 2003.
126 Isono M, Mogyorosi A, Han DC, Hoffman BB, Ziyadeh FN: Stimulation of TGF-B type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney. Amer Journal of Physiology 278: F830-F838, 2000.
110 Dell M, Hoffman BB, Leonard MB, Ziyadeh FN, Schulman SL: Increased urinary transforming growth factor beta-1 (TGF-B1) excretion in children with posterior urethral valves. Urology 56(2): 311-4, 2000.
1a5 Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice. PNAS 97(14): 8015-20, 2000.
10e Han DC, Hoffman BB, Guo J, Ziyadeh FN: Therapy with antisense TGF-B1 oligodeoxynucleotides reduces kidney weight and matrix mRNA's in diabetic mice. Amer Journal of Physiology 278: F628-F634, 2000.
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Selected Publications
35 Boyle, SM b Jacobs, B b Sayni, FA a1 Hoffman, B: Management of the Dialysis Patient with Sickle Cell Disease. Seminars in Dialysis 29(1): 62-70, January/February 2016.105 Barbieri J, Seshasai R, Shemash A, Sedrak M, Hoffman B, Alley E: Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. Journal of Thoracic Oncology 8(6): e57-8, June 2013.
f0 Tan A, Hoffman B, Rosas SE: Patient perception of risk factors associated with chronic kidney disease morbidity and mortality. Ethnicity and Disease 20: 106-108, 2010.
52 Hoffman BB: Peritoneal Dialysis 2 2 2 2 2 2 2 2 2 2 8f Current Diagnosis and Treatment in Nephrology and Hypertension. McGraw-Hill, Chapter 51(Section 8): 444-452, Jan 2009.
e1 Hoffman BB: Surgery in the Patient with Kidney Disease. Medical Management of the Surgical Patient 3rd edition. Elsevier, Chapter 18: 605-632, Feb 2008.
111 Chen S, Hoffman BB, Jim B, Lee JS, Kopp JB, Ziyadeh FN: Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose. Kidney Intl 65: 1191-1204, 2004.
102 Chen S, Lee JS, Hoffman BB, Ziyadeh FN: Cultured tubule cells from TGF-beta 1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose JASN 14: 128A, 2003.
126 Isono M, Mogyorosi A, Han DC, Hoffman BB, Ziyadeh FN: Stimulation of TGF-B type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney. Amer Journal of Physiology 278: F830-F838, 2000.
110 Dell M, Hoffman BB, Leonard MB, Ziyadeh FN, Schulman SL: Increased urinary transforming growth factor beta-1 (TGF-B1) excretion in children with posterior urethral valves. Urology 56(2): 311-4, 2000.
1a5 Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice. PNAS 97(14): 8015-20, 2000.
10e Han DC, Hoffman BB, Guo J, Ziyadeh FN: Therapy with antisense TGF-B1 oligodeoxynucleotides reduces kidney weight and matrix mRNA's in diabetic mice. Amer Journal of Physiology 278: F628-F634, 2000.
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