Brenda Barber Hoffman, MD

faculty photo
Associate Professor of Clinical Medicine
Department: Medicine

Contact information
240 Medical Office Building
Penn Presbyterian Medical Center
39th & Market Street
Philadelphia, PA 19104
Office: 215-662-8730
Fax: 215-243-4686
B.A. (Biology)
Franklin and Marshall College, 1985.
University of Pennsylvania, 1989.
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Description of Clinical Expertise

Chronic kidney disease, Acute kidney injury, In center hemodialysis, Peritoneal dialysis, Acute dialysis, Kidney stones, Diabetic kidney disease

Selected Publications

Boyle, SM Jacobs, B Sayni, FA Hoffman, B: Management of the Dialysis Patient with Sickle Cell Disease. Seminars in Dialysis 29(1): 62-70, January/February 2016.

Barbieri J, Seshasai R, Shemash A, Sedrak M, Hoffman B, Alley E: Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. Journal of Thoracic Oncology 8(6): e57-8, June 2013.

Tan A, Hoffman B, Rosas SE: Patient perception of risk factors associated with chronic kidney disease morbidity and mortality. Ethnicity and Disease 20: 106-108, 2010.

Hoffman BB: Peritoneal Dialysis Current Diagnosis and Treatment in Nephrology and Hypertension. McGraw-Hill, Chapter 51(Section 8): 444-452, Jan 2009.

Hoffman BB: Surgery in the Patient with Kidney Disease. Medical Management of the Surgical Patient 3rd edition. Elsevier, Chapter 18: 605-632, Feb 2008.

Chen S, Hoffman BB, Jim B, Lee JS, Kopp JB, Ziyadeh FN: Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose. Kidney Intl 65: 1191-1204, 2004.

Chen S, Lee JS, Hoffman BB, Ziyadeh FN: Cultured tubule cells from TGF-beta 1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose JASN 14: 128A, 2003.

Isono M, Mogyorosi A, Han DC, Hoffman BB, Ziyadeh FN: Stimulation of TGF-B type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney. Amer Journal of Physiology 278: F830-F838, 2000.

Dell M, Hoffman BB, Leonard MB, Ziyadeh FN, Schulman SL: Increased urinary transforming growth factor beta-1 (TGF-B1) excretion in children with posterior urethral valves. Urology 56(2): 311-4, 2000.

Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice. PNAS 97(14): 8015-20, 2000.

Han DC, Hoffman BB, Guo J, Ziyadeh FN: Therapy with antisense TGF-B1 oligodeoxynucleotides reduces kidney weight and matrix mRNA's in diabetic mice. Amer Journal of Physiology 278: F628-F634, 2000.

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Last updated: 12/19/2017
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