Natalie E. Rintoul, MD

faculty photo
Professor of Clinical Pediatrics (Neonatology & Newborn Services)
Attending Physician, Children's Hospital of Philadelphia
Fetal Consultant, Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia
ECMO Resource Attending, Children's Hospital of Philadelphia
Medical Director, Neonatal Extracorporeal Membrane Oxygenation (ECMO), Children's Hospital of Philadelphia
Medical Director, Neonatal Surgical Service, Children's Hospital of Philadelphia
Medical Co-Director Neonatal SDU Service, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Department of Neonatology
34th and Civic Center Boulevard
Philadelphia, PA 19104
Email: rintoul@email.chop.edu
Education:
(General Science)
McGill University, 1987.
 BS (Science)
Queen's University, 1991.
 MD
Queen's University, 1995.
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Description of Research Expertise

IRB 13-010759
Protocol Name: Reintubation of post surgical neonates
PI: David Cohen
Study Contact Theodora Goebel
Primary Funder: Children's Anesthesiology Associate

Fetal Tracheal Occlusion Congenital Diaphragmatic Hernia

IRB 3779
Pulmonary Hypoplasia Program

Milrinone IRB
Gastroschisis IRB
Maternal Progesterone/Fetal Neuroprotection IRB
Gastroschisis Imaging IRB

Re: IRB 17-013902, Protocol Title: Congenital renal and urinary tract anomalies with associated pulmonary hypoplasia: A case series (2017)
PI: Natalie Rintoul

Re: IRB 18-014829
Protocol Title: Delivery Room Management of Transposition of the Great Arteries (TGA) and Short Term Outcomes: A Descriptive Study (2018)
PI: Natalie Rintoul

IRB 18-014850
Outcomes in ECMO treated neonates
Sara Demauro, Faith Kim Natalie Rintoul

A pilot feasibility and safety multi center trial of administering weight adjusted fixed dose of low molecular weight heparin (enoxaparin) to neonates with thrombosis (FiXET): study protocol
Leslie Raffini, MD; Natalie Rintoul, MD (co-investigator)

Description of Clinical Expertise

Care of the Surgical Neonate
Resuscitation of the Anomalous Neonate
Palliative Care
Perioperative Care of Newborns/Infants
Neonatal, Extracorporeal Membrane Oxygenation (ECMO)

Melomeningocele care map (Heuer G, Flibotte J)
Lymphangioma sleep disorders

PreOp Guideline in the Fetal/SDU Section of the Guideline for Neonates with Critical Heart Defects Undergoing Intervention, CHOP Neonatal Critical Heart Defects (CHD) Cardiology QI Project, 2018-2019.
Notes: Educational and procedural material for the Special Delivery Unit at Children's Hospital of Philadelphia

Selected Publications

Johng S, Rintoul N, Puia-Dumitrescu M, Handley S, Billimoria Z, Lichtsinn K, Yalon L, Connelly J, Carr N , Heyrend C, Miquel-Verges F, McCulley D, Yang M, Lusk L, Gowda S, Montgomery K, DiGeronimo R on behalf of the CHNC ECMO Focus Group: Anticoagulation Practices for Neonatal Respiratory ECMO Therapy within the Children’s Hospitals Neonatal Consortium. Pediatric Academic Societies (PAS), Honolulu, Hawaii April 2025 Notes: Poster Presentation.

 Johng S, Radack J, DeMauro S, DiGeronimo R, Raffini L, Keene S, Mathew L, Connelly J, Hedrick H, Rintoul N: Bleeding and Thrombotic Events in Neonates Supported with VA ECMO: An Analysis of the ELSO Registry. Pediatric Academic Societies (PAS), Honolulu, Hawaii April 2025 Notes: Platform Presentation.

 Carr N, Fulmer M, Rumpel J, Makkar A, Mahmood B, Keene S, Rintoul N, Wild KT, Ashrafi A, Gogcu S, Rau C, Mankouski A, Pattison D, Best H, Boyden S, Mao R, Brunelli L: Efficacy of Universal Genome Sequencing in Infant Extracorporeal Membrane Oxygenation. Pediatric Academic Societies (PAS), Honolulu, Hawaii April 2025 Notes: Poster Presentation.

 Johng S, DiGeronimo R, Puia-Dumitrescu M, Handley S, Billimoria Z, Lichtsinn K, Yalon L, Connelly J, Carr N , Heyrend C, Miquel-Verges F, McCulley D, Yang M, Lusk L, Gowda S, Montgomery K, Rintoul N on behalf of the CHNC ECMO Focus Group : Management of Bivalirudin for Primary Anticoagulation in Neonatal Respiratory ECMO Therapy within the Children’s Hospitals Neonatal Consortium. Pediatric Academic Societies (PAS), Honolulu, Hawaii April 2025 Notes: Poster Presentation.

 Johng S, Rintoul N, Puia-Dumitrescu M, Handley S, Billimoria Z, Lichtsinn K, Yalon L, Connelly J, Carr N , Heyrend C, Miquel-Verges F, McCulley D, Yang M, Lusk L, Gowda S, Montgomery K, DiGeronimo R on behalf of the CHNC ECMO Focus Group: Anticoagulation Practices for Neonatal Respiratory ECMO Therapy within the Children’s Hospitals Neonatal Consortium. 41st Annual Children's National Symposium: ECMO and the Advanced Therapies for Cardiovascular and Respiratory Failure Symposium, Keystone, Colorado March 2025 Notes: Platform Presentation.

 Moon, J, Yuan I, Oluwalade B, Rintoul N, Wild T, Chen S, Simpao A, Nelson O: “Short term outcomes in infants following primary ventriculoperitoneal (VP) shunt insertion” Society for Pediatric Anesthesiology (SPA-AAP), Orlando, FL March 2025 Notes: Oral Presentation.

 Arens J, Barlett R, Church J, Hirschl R, Mychaliska G, Rintoul N, Zwischenberger: "ECLS of the Future - Where Will We Be in 25 Years?" 41st Annual Children's National Symposium: ECMO and the Advanced Therapies for Cardiovascular and Respiratory Failure Symposium, Keystone, Colorado March 2025 Notes: Oral Presentation.

 Johng S, DiGeronimo R, Puia-Dumitrescu M, Handley S, Billimoria Z, Lichtsinn K, Yalon L, Connelly J, Carr N , Heyrend C, Miquel-Verges F, McCulley D, Yang M, Lusk L, Gowda S, Montgomery K, Rintoul N on behalf of the CHNC ECMO Focus Group: Management of Bivalirudin for Primary Anticoagulation in Neonatal Respiratory ECMO Therapy within the Children’s Hospitals Neonatal Consortium. 41st Annual Children's National Symposium: ECMO and the Advanced Therapies for Cardiovascular and Respiratory Failure Symposium, Keystone, Colorado March 2025 Notes: Platform Presentation.

 Johng S, Rintoul N, Puia-Dumitrescu M, Billimoria Z, Handley S, Lichtsinn K, Yalon L, Connelly J, Carr N, Heyrend C, Miquel-Verges F, Lusk L, Yang M, McCulley D, DiGeronimo R on behalf of the CHNC ECMO Focus Group: Anticoagulation practices for neonatal respiratory ECMO therapy within the Children’s Hospitals Neonatal Consortium. CHNC Annual Symposium, Denver, Colorado October 2024 Notes: Poster presentation.

 Johng S, DiGeronimo R, Puia-Dumitrescu M, Billimoria Z, Handley S, Lichtsinn K, Yalon L, Connelly J, Carr N, Heyrend C, Miquel-Verges F, Lusk L, Yang M, McCulley D, Rintoul N on behalf of the CHNC ECMO Focus Group: Management of Bivalirudin for Primary Anticoagulation in Neonatal Respiratory ECMO Therapy within the Children’s Hospitals Neonatal Consortium. CHNC Annual Symposium, Denver, Colorado October 2024 Notes: Platform presentation.
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Last updated: 03/07/2025
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