Natalie E. Rintoul, MD
Professor of Clinical Pediatrics (Neonatology & Newborn Services)
Attending Physician, Children's Hospital of Philadelphia
Fetal Consultant, Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia
ECMO Resource Attending, Children's Hospital of Philadelphia
Medical Director, Neonatal Extracorporeal Membrane Oxygenation (ECMO), Children's Hospital of Philadelphia
Medical Director, Neonatal Surgical Service, Children's Hospital of Philadelphia
Medical Co-Director Neonatal SDU Service, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Department of Neonatology
34th and Civic Center Boulevard
Philadelphia, PA 19104
Department of Neonatology
34th and Civic Center Boulevard
Philadelphia, PA 19104
Email:
rintoul@email.chop.edu
rintoul@email.chop.edu
Education
(General Science)
McGill University, 1987.
BS (Science)
Queen's University, 1991.
MD
Queen's University, 1995.
Permanent link(General Science)
McGill University, 1987.
BS (Science)
Queen's University, 1991.
MD
Queen's University, 1995.
Description of Research Expertise
IRB 13-010759Protocol Name: Reintubation of post surgical neonates
PI: David Cohen
Study Contact Theodora Goebel
Primary Funder: Children's Anesthesiology Associate
Fetal Tracheal Occlusion Congenital Diaphragmatic Hernia
IRB 3779
Pulmonary Hypoplasia Program
Milrinone IRB
Gastroschisis IRB
Maternal Progesterone/Fetal Neuroprotection IRB
Gastroschisis Imaging IRB
Re: IRB 17-013902, Protocol Title: Congenital renal and urinary tract anomalies with associated pulmonary hypoplasia: A case series (2017)
PI: Natalie Rintoul
Re: IRB 18-014829
Protocol Title: Delivery Room Management of Transposition of the Great Arteries (TGA) and Short Term Outcomes: A Descriptive Study (2018)
PI: Natalie Rintoul
IRB 18-014850
Outcomes in ECMO treated neonates
Sara Demauro, Faith Kim Natalie Rintoul
A pilot feasibility and safety multi center trial of administering weight adjusted fixed dose of low molecular weight heparin (enoxaparin) to neonates with thrombosis (FiXET): study protocol
Leslie Raffini, MD; Natalie Rintoul, MD (co-investigator)
Description of Clinical Expertise
Care of the Surgical NeonateResuscitation of the Anomalous Neonate
Palliative Care
Perioperative Care of Newborns/Infants
Neonatal, Extracorporeal Membrane Oxygenation (ECMO)
Melomeningocele care map (Heuer G, Flibotte J)
Lymphangioma sleep disorders
PreOp Guideline in the Fetal/SDU Section of the Guideline for Neonates with Critical Heart Defects Undergoing Intervention, CHOP Neonatal Critical Heart Defects (CHD) Cardiology QI Project, 2018-2019.
Notes: Educational and procedural material for the Special Delivery Unit at Children's Hospital of Philadelphia
Selected Publications
Blair J, Carratu K, Rintoul NE, Hedrick HL, Peranteau WH, Avitabile CM, McWalter K, Kruszka P, Krantz ID, Wild KT: Genomic Contributors to Congenital Diaphragmatic Hernia: Results of Exome Sequencing in 560 Probands and Cross Reference of Findings in an Independent Cohort. Am J Med Genet A 200(8): 1821-1831, August 2026 Notes: doi: 10.1002/ajmg.a.70145. Epub 2026 Apr 6.Gist KM, Selewski DT, Kashani KB, Akcan-Arikan A, Annich G, Antonini MV, Askenazi D, Awdishu L, Bridges BC, Connor MJ Jr, Forni LG, Fuhrman DY, Goldstein SL, Gorga SM, Guru PK, Kaddourah A, Lepage-Farrell A, McMullan DM, Mehta RL, Menon S, Mottes T, Müeller T, Ostermann M, Paden ML, Rintoul NE, Reis T, Ronco C, See E, Singh G, Bagshaw SM, MacLaren G: Extracorporeal membrane oxygenation, acute kidney injury, fluid balance, and continuous renal replacement therapy: Acute Disease Quality Initiative (ADQI) and Extracorporeal Life Support Organization (ELSO) joint consensus conference. Intensive Care Med 52(6): 1175-1195, June 2026 Notes: doi: 10.1007/s00134-026-08440-3. Epub 2026 May 6.
Johng S, Goncalves FG, DeMauro SB, Hsu JY, Licht DJ, Rintoul N, Hedrick HL, Hoffman C, Vossough A: A Novel Neonatal Brain Injury Score for Infants With Congenital Diaphragmatic Hernia. Pediatr Neurol 182: 11-20, June 2026 Notes: doi: 10.1016/j.pediatrneurol.2026.05.017. Epub ahead of print.
Ahmed S, Mahmood B, Daniel J, Johng S, Strong A, Ibrahim J, Hu J, Short K, Montgomery K, Drake K, Bhakta K, Lusk L, Revenis M, Thakkar P, Seabrook R, Pandya S, Keene S, Gowda S, Hoffman S, Mohamed T, Beck T, Najaf T, DiGeronimo R, Rintoul N, Makkar A: Use of extracorporeal membrane oxygenation in neonates with congenital anomalies of the kidney and urinary tract: a multicenter survey of current practices across CHNC and Pedi-ECMO centers. Pediatr Nephrol May 2026 Notes: doi: 10.1007/s00467-026-07301-x. Epub ahead of print.
Wild KT, Rintoul NE, Ades AM, Khalek N, Gebb JS, Oliver ER, Reynolds T, Mathew L, Herrick HM, Matthews K, Heimall L, Nelson O, Bruins BB, Rychik J, Partridge EA, Flake AW, Hedrick HL: Delivery room resuscitation of conjoined twins. J Perinatol May 2026 Notes: doi: 10.1038/s41372-026-02735-5. Epub ahead of print.
Carr NR, Fulmer ML, Rumpel J, Makkar A, Mahmood B, Keene S, Rintoul N, Taylor Wild K, Ashrafi A, Gogcu S, Rau C, Pattison D, Best H, Boyden SE, Mao R, Brunelli L: Efficacy of universal genome sequencing in infant extracorporeal membrane oxygenation. J Perinatol May 2026 Notes: doi: 10.1038/s41372-026-02716-8. Epub ahead of print.
Bostwick A, Foglia E, Mathew L, Wild T, Ades A, Rintoul N, Reynolds T, Gresh L, Lee S, Gebb J, Hedrick H: "Defining Peripheral Oxygen Saturation Reference Ranges After Birth for Newborns with Congenital Diaphragmatic Hernia" 97th Pediatric Academic Societies (PAS), Boston, MA April 2026 Notes: Oral presentation.
Chandhoke S, Zaniletti I, DiGeronimo R, Hamrick SEG, Murthy K, Padula MA, Rintoul NE, Grover TR, Levy PT, Moynihan KM; CHNC ECMO Focus Group: Neonatal extracorporeal membrane oxygenation outcomes according to social determinants of health. J Perinatol April 2026 Notes: doi: 10.1038/s41372-026-02668-z. Epub ahead of print.
Simpao AF, Chou ST, Soni S, Mesaros, AC, Capers S, Mewha J, Thom CS, Rintoul NE, Hawkins J, Nelson O: "Lead Contamination in Donated Packed Red Blood Cells: Implications for intrauterine transfusions and neonates receiving transfusions" Society of Obstetric Anesthesia and Perinatology, 58th Annual Meeting, Montreal, Quebec, Canada April 2026 Notes: Oral Presentation by Olivia Nelson.
Ibrahim J, Carr N, Verges FM, Rintoul N, DiGeronimo R, Daniel J, Keene S, Mahmood B: ECMO use in infants with bronchopulmonary dysplasia: a literature review. J Perinatol March 2026 Notes: doi: 10.1038/s41372-025-02506-8. Epub ahead of print.