Gregory E. Supple, MD
Associate Professor of Clinical Medicine (Cardiovascular Medicine)
Director, Inpatient EP Services, Hospital of the University of Pennsylvania
Associate Director, Electrophysiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA
Director, Cardiac Electrophysiology Fellowship Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Department: Medicine
Contact information
Hospital of the University of Pennsylvania
Cardiovascular Medicine Division, Electrophysiology Section
Pavilion 2 City Side
1 Convention Ave.
Philadelphia, PA 19104
Cardiovascular Medicine Division, Electrophysiology Section
Pavilion 2 City Side
1 Convention Ave.
Philadelphia, PA 19104
Office: 215-615-3811
Publications
Education:
B.A (Chemistry)
Wesleyan University, 2000.
M.D.
University of Pennsylvania School of Medicine, 2005.
Permanent linkB.A (Chemistry)
Wesleyan University, 2000.
M.D.
University of Pennsylvania School of Medicine, 2005.
Description of Clinical Expertise
ablation - Wolff-Parkinson-White syndrome (WPW)atrial fibrillation
atrial fibrillation - pulmonary vein isolation
atrial flutter ablation
biventricular device optimization
bradycardia
cardiac ablation
defibrillator implantation
ECG - electrocardiography
electrocardiogram
electrophysiology
epicardial ablation
heart rhythms - slow/fast
idiopathic tachycardia ablation
implantable cardioverter-defibrillator
intracardiac echocardiography
ischemic tachycardia ablation
pacemaker implantation
pacemakers
radiofrequency ablation
supraventricular tachycardia (SVT)
tachycardia
ventricular tachycardia
ventricular tachycardia ablations
Selected Publications
Shivamurthy P, Cevasco M, Supple GE, Hanumanthu BK, Markman TM, Guandalini G, Hyman MC, Enriquez A, Kumareswaran R, Fradley MG, Deo R, See VY, Riley M, Garcia F, Nazarian S, Lin D, Frankel DS, Dixit S, Epstein AE, Callans DJ, Marchlinski FE, Schaller RD.: Epicardial placement of implantable cardioverter-defibrillators in adults: Technical considerations, system performance, and clinical outcomes. Heart Rhythm Page: e908-e918, Oct 2025.Zghaib T, Enriquez A, Schaller RD, Dixit S, Supple GE, Garcia FC, Callans DJ, Hyman MC, Frankel DS, Marchlinski FE, Nazarian S, Markman TM.: Coronary venous ethanol infusion for treatment of refractory ventricular arrhythmias. Heart Rhythm Page: e682-e690, Sep 2025.
Chaumont C, Oraii A, Rodriguez-Queralto O, Petzl A, Zado E, Hanumanthu BKJ, Markman TM, Hyman MC, Tschabrunn CM, Enriquez A, Shivamurthy P, Kumareswaran R, Riley MP, Lin D, Schaller RD, Nazarian S, Callans DJ, Supple GE, Garcia FC, Frankel DS, Dixit S, Anselme F, Marchlinski FE.: Sex-Related Differences in Non-Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation. JAMA Netw Open 8: e2529527, Aug 2025.
Chaumont C, Petzl AM, Tschabrunn CM, Oraii A, Rodriguez-Queralto O, Sugrue AM, Mirwais M, Markman TM, Supple GE, Hyman MC, Nazarian S, Callans DJ, Garcia FC, Frankel DS, Anselme F, Marchlinski FE.: Ablation of ventricular tachycardia from right ventricular aneurysms in patients with arrhythmogenic cardiomyopathy guided by intracardiac echocardiography. Heart Rhythm Page: 1969-1974, August 2025.
Peters CJ, Supple GE.: Step-by-Step Approach to Phrenic Nerve Displacement. J Cardiovasc Electrophysiol Page: 1201-1212, Jun 2025.
Austin MA, Supple GE, Carrell S, Quinn C, Elman L, Nazarian S.: Reply: Extended Cardiac Rhythm Monitoring Detects More Arrhythmias in Myotonic Dystrophy Patients. JACC Clin Electrophysiol Jun 2025.
Oraii A, Hanumanthu BKJ, Petzl A, Liao TW, Afzalian A, Rodriguez-Queralto O, Chaumont C, Spears J, Markman TM, Hyman MC, Tschabrunn CM, Guandalini G, Enriquez A, Shivamurthy P, Kumareswaran R, Deo R, Ferrari VA, Riley MP, Lin D, Callans DJ, Supple GE, Schaller RD, Frankel DS, Garcia FC, Nazarian S, Dixit S, Marchlinski FE.: Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes. Europace 27: euaf100, Jun 2025.
Austin MA, Supple GE, Carrell S, Quinn C, Elman L, Nazarian S.: Reply: Advancing Risk Assessment in Myotonic Muscular Dystrophy Through Translational Research and Personalized Medicine. JACC Clin Electrophysiol May 2025.
Austin MA, Supple GE, Carrell S, Quinn C, Elman L, Nazarian S.: Atrial Fibrillation and Flutter in a Contemporary Cohort of Patients With Myotonic Muscular Dystrophy. JACC Clin Electrophysiol Page: 933-941, May 2025.
Petzl AM, Oranefo J, Oraii A, Riley M, Lin D, Kumareswaran R, Schaller RD, Supple GE, Markman TM, Guandalini G, Hyman MC, Frankel DS, Epstein AE, Nazarian S, Garcia FC, Deo R, Callans DJ, Marchlinski FE, Dixit S.: Outcomes in patients with cardiac amyloidosis undergoing catheter ablation for atrial arrhythmias. Heart Rhythm O2 6: 1088-1096, May 2025.