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Gregory E. Supple, MD

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Associate Professor of Clinical Medicine (Cardiovascular Medicine)
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Director, Inpatient EP Services, Hospital of the University of Pennsylvania
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Associate Director, Electrophysiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA
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Director, Cardiac Electrophysiology Fellowship Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
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Department: Medicine
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46 Contact information
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Hospital of the University of Pennsylvania
43 Cardiovascular Medicine Division, Electrophysiology Section
1c Pavilion 2 City Side
34 1 Convention Ave.
Philadelphia, PA 19104
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2e Office: 215-615-3811
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Email: gregory.supple@pennmedicine.upenn.edu
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18 Publications
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Links
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13 Education:
21 8 B.A 16 (Chemistry) c
2c Wesleyan University, 2000.
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46 University of Pennsylvania School of Medicine, 2005.
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Description of Clinical Expertise

40 ablation - Wolff-Parkinson-White syndrome (WPW)
1b atrial fibrillation
36 atrial fibrillation - pulmonary vein isolation
1f atrial flutter ablation
29 biventricular device optimization
13 bradycardia
18 cardiac ablation
22 defibrillator implantation
21 ECG - electrocardiography
19 electrocardiogram
19 electrophysiology
1b epicardial ablation
21 heart rhythms - slow/fast
27 idiopathic tachycardia ablation
2e implantable cardioverter-defibrillator
25 intracardiac echocardiography
25 ischemic tachycardia ablation
1e pacemaker implantation
12 pacemakers
1f radiofrequency ablation
2a supraventricular tachycardia (SVT)
13 tachycardia
1f ventricular tachycardia
28 ventricular tachycardia ablations
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Selected Publications

200 Shivamurthy P, Cevasco M, Supple GE, Hanumanthu BK, Markman TM, Guandalini G, Hyman MC, Enriquez A, Kumareswaran R, Fradley MG, Deo R, See VY, Riley M, Garcia F, Nazarian S, Lin D, Frankel DS, Dixit S, Epstein AE, Callans DJ, Marchlinski FE, Schaller RD.: Epicardial placement of implantable cardioverter-defibrillators in adults: Technical considerations, system performance, and clinical outcomes. Heart Rhythm Page: e908-e918, Oct 2025.

 153 Zghaib T, Enriquez A, Schaller RD, Dixit S, Supple GE, Garcia FC, Callans DJ, Hyman MC, Frankel DS, Marchlinski FE, Nazarian S, Markman TM.: Coronary venous ethanol infusion for treatment of refractory ventricular arrhythmias. Heart Rhythm Page: e682-e690, Sep 2025.

 1eb Chaumont C, Oraii A, Rodriguez-Queralto O, Petzl A, Zado E, Hanumanthu BKJ, Markman TM, Hyman MC, Tschabrunn CM, Enriquez A, Shivamurthy P, Kumareswaran R, Riley MP, Lin D, Schaller RD, Nazarian S, Callans DJ, Supple GE, Garcia FC, Frankel DS, Dixit S, Anselme F, Marchlinski FE.: Sex-Related Differences in Non-Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation. JAMA Netw Open 8: e2529527, Aug 2025.

 1d6 Chaumont C, Petzl AM, Tschabrunn CM, Oraii A, Rodriguez-Queralto O, Sugrue AM, Mirwais M, Markman TM, Supple GE, Hyman MC, Nazarian S, Callans DJ, Garcia FC, Frankel DS, Anselme F, Marchlinski FE.: Ablation of ventricular tachycardia from right ventricular aneurysms in patients with arrhythmogenic cardiomyopathy guided by intracardiac echocardiography. Heart Rhythm Page: 1969-1974, August 2025.

 cb Peters CJ, Supple GE.: Step-by-Step Approach to Phrenic Nerve Displacement. J Cardiovasc Electrophysiol Page: 1201-1212, Jun 2025.

 11b Austin MA, Supple GE, Carrell S, Quinn C, Elman L, Nazarian S.: Reply: Extended Cardiac Rhythm Monitoring Detects More Arrhythmias in Myotonic Dystrophy Patients. JACC Clin Electrophysiol 11(6): 1348, Jun 2025.

 22f Oraii A, Hanumanthu BKJ, Petzl A, Liao TW, Afzalian A, Rodriguez-Queralto O, Chaumont C, Spears J, Markman TM, Hyman MC, Tschabrunn CM, Guandalini G, Enriquez A, Shivamurthy P, Kumareswaran R, Deo R, Ferrari VA, Riley MP, Lin D, Callans DJ, Supple GE, Schaller RD, Frankel DS, Garcia FC, Nazarian S, Dixit S, Marchlinski FE.: Catheter ablation of atrial fibrillation in patients with cardiac amyloidosis and sarcoidosis: procedural findings and outcomes. Europace 27: euaf100, Jun 2025.

 132 Austin MA, Supple GE, Carrell S, Quinn C, Elman L, Nazarian S.: Reply: Advancing Risk Assessment in Myotonic Muscular Dystrophy Through Translational Research and Personalized Medicine. JACC Clin Electrophysiol 11(5): 1040, May 2025.

 121 Austin MA, Supple GE, Carrell S, Quinn C, Elman L, Nazarian S.: Atrial Fibrillation and Flutter in a Contemporary Cohort of Patients With Myotonic Muscular Dystrophy. JACC Clin Electrophysiol Page: 933-941, May 2025.

 1a9 Petzl AM, Oranefo J, Oraii A, Riley M, Lin D, Kumareswaran R, Schaller RD, Supple GE, Markman TM, Guandalini G, Hyman MC, Frankel DS, Epstein AE, Nazarian S, Garcia FC, Deo R, Callans DJ, Marchlinski FE, Dixit S.: Outcomes in patients with cardiac amyloidosis undergoing catheter ablation for atrial arrhythmias. Heart Rhythm O2 6: 1088-1096, May 2025.

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