Gregory E. Supple, MD
Professor of Clinical Medicine (Cardiovascular Medicine)
Director, Inpatient EP Services, Hospital of the University of Pennsylvania
Associate Director, Electrophysiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA
Director, Cardiac Electrophysiology Fellowship Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Department: Medicine
Contact information
Hospital of the University of Pennsylvania
Cardiovascular Medicine Division, Electrophysiology Section
Pavilion 2 City Side
1 Convention Ave.
Philadelphia, PA 19104
Cardiovascular Medicine Division, Electrophysiology Section
Pavilion 2 City Side
1 Convention Ave.
Philadelphia, PA 19104
Office: 215-615-3811
Publications
Education
B.A (Chemistry)
Wesleyan University, 2000.
M.D.
University of Pennsylvania School of Medicine, 2005.
Permanent linkB.A (Chemistry)
Wesleyan University, 2000.
M.D.
University of Pennsylvania School of Medicine, 2005.
Description of Clinical Expertise
ablation - Wolff-Parkinson-White syndrome (WPW)atrial fibrillation
atrial fibrillation - pulmonary vein isolation
atrial flutter ablation
biventricular device optimization
bradycardia
cardiac ablation
defibrillator implantation
ECG - electrocardiography
electrocardiogram
electrophysiology
epicardial ablation
heart rhythms - slow/fast
idiopathic tachycardia ablation
implantable cardioverter-defibrillator
intracardiac echocardiography
ischemic tachycardia ablation
pacemaker implantation
pacemakers
radiofrequency ablation
supraventricular tachycardia (SVT)
tachycardia
ventricular tachycardia
ventricular tachycardia ablations
Description of Research Expertise
Ventricular arrhythmia ablationSelected Publications
Tan JL, Chirinos J, Patel D, Jagasia D, Hyman MC, Guandalini GS, Nazarian S, Lin D, Supple G, Frankel DS, Callans DJ, Marchlinski FE, Ren JF, Markman TM.: Intracardiac echocardiography for left ventricular diastolic function assessment during atrial fibrillation ablation. J Interv Card Electrophysiol Aug 2026.Litt MJ, Gad MM, Heravi A, Supple GE, Markman TM, DePietro D, Dixit S.: Transhepatic Access for Pulsed Field Ablation of Atrial Fibrillation Using a Dual-Energy Lattice-Tip Catheter. JACC Case Rep Jul 2026.
Yogasundaram H, Petzl AM, Chaumont C, Keane S, Oranefo J, Hanumanthu BK, Supple GE, Markman TM, Hyman M, Stuckey M, Shivamurthy P, Callans DJ, Dixit S, Schaller RD, Nazarian S, Lin D, Frankel DS, Guandalini G, Marchlinski FE, Enriquez A, Garcia FC.: Intraseptal Mapping of Premature Ventricular Complexes Using Multipolar Catheters. JACC Clin Electrophysiol May 2026.
Oraii A, Afzalian A, Chaumont C, Rodriguez-Queralto O, Liao TE, Gad MM, Zaidi SMM, Zado E, Tschabrunn CM, Hanumanthu BKJ, Hyman MC, Markman TM, Guandalini G, Kumareswaran R, Deo R, Riley MP, Lin D, Garcia FC, Nazarian S, Supple GE, Schaller RD, Frankel DS, Callans DJ, Dixit S, Marchlinski FE.: Role of Non-Pulmonary Vein Triggers in Outcomes of First-Time Atrial Fibrillation Ablation. JACC Clin Electrophysiol May 2026.
Boyle TA, Callans DC, Deo R, Dixit S, Enriquez A, Epstein AE, Garcia F, Guandalini G, Hanumanthu BK, Hyman MC, Kumareswaran R, Lin D, Marchlinski FE, Markman TM, Mirwais M, Nazarian S, Riley M, See V, Shivamurthy P, Supple GE, Schaller R, Frankel DS.: Quantitative Vector Screening to Improve Sensing and Reduce Inappropriate Shocks With the Subcutaneous Implantable Cardioverter Defibrillator. Circ Arrhythm Electrophysiol May 2026.
Supple GE.: AF Ablation and Autonomic Provocation: A New Type of Holiday Heart? JACC Clin Electrophysiol Apr 2026.
Patel D, Vardar U, Mai W, Grubb A, van Niekerk CJ, Sugrue A, Garg L, Pothenini NVK, Supple GE, Nazarian S, Deo R, Enriquez A, Callans DJ, Schaller RD, Hyman MC, Frankel DS, Marchlinski FE, Markman TM.: Predicting Survival in Ventricular Tachycardia Storm: The CHAMPS Risk Score and Implications for Ablation Timing. JACC Clin Electrophysiol Apr 2026.
Guandalini GS, Riley M, Supple GE, Hyman MC, Lin D, Marchlinski FE.: Recurrent Malignant Ventricular Arrhythmias Due to Coronary Vasospasm: A Case for Secondary Prevention ICD Implantation. JACC Clin Electrophysiol Apr 2026.
van Niekerk CJ, Cerantola M, Sugrue A, Mirwais M, Hyman MC, Frankel DS, Supple G, Marchlinski F, Schaller RD.: Retained Wire Lead Extraction Techniques in Patients With Venous Occlusion. JACC Clin Electrophysiol Mar 2026.
Austin MA, Spears J, Supple GE, Carrell S, Elman L, Nazarian S.: Atrial arrhythmia ablation in myotonic muscular dystrophy patients: a single institution experience. J Interv Card Electrophysiol Mar 2026.