1e
19
1
49
2
2
18
1b
1d
18
41
78
1d
2 29
1d
25
Emanuela Ricciotti, Pharm.D., Ph.D.
78
78
Research Associate Professor of Systems Pharmacology and Translational Therapeutics
7
8a
Department: Systems Pharmacology and Translational Therapeutics
4
1
b
1d
46
Contact information
56
4
3
3
1d
56
Smilow Center for Translational Research
4c 3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104
26
4c 3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104
2e
Office: 215-898-9391
32 Fax: 215-573-9135
24
9f
12
32 Fax: 215-573-9135
24
18
Publications
23 a
3
2
29
23 a
Links
a3 Search PubMed for articles
d
4
b
1f
a3 Search PubMed for articles
d
13
Education:
21 c Pharm.D c
42 "G. d`Annunzio" University, Chieti, Italy, 2001.
21 8 PhD 1d (Science of Aging) c
42 "G. d`Annunzio" University, Chieti, Italy, 2005.
c
3
3
3
3
8d
Permanent link21 c Pharm.D c
42 "G. d`Annunzio" University, Chieti, Italy, 2001.
21 8 PhD 1d (Science of Aging) c
42 "G. d`Annunzio" University, Chieti, Italy, 2005.
c
2 29
21
1e
1d
24
5e
9f I have contributed to understand the human pharmacology of non-steroidal anti-inflammatory drugs (NSAID)s and how they harm the cardiovascular system.
ee My current research focuses on defining the role and regulation of eicosanoids and other bioactive lipids in cardiovascular disease, aging, the response to checkpoint blockade in cancer, and viral infections, such as in COVID-19.
b1 I am also investigating the mechanisms underlying NSAID-induced enteropathy and the time-dependent effect of low-dose aspirin on platelet reactivity and blood pressure.
a8 For my research I integrate studies in model systems using multi-omic (lipidomics, single-cell transcriptomics, metagenomics) and immune profiling approaches.
1f Cyclooxygenase biology.
19 Vascular biology.
3d Pharmacology of nonsteroidal anti-inflammatory drugs.
1c System pharmacology.
10 Genomic.
15 Metabolomics.
13 Microbiome.
17 Rna-Sequencing.
18 Atherosclerosis.
16 Heart Failure.
1e Myocardial infarction.
13 Thrombosis.
1d Platelet Aggregation.
21 NSAID-induced enteropathy.
26 7 1d 1f
27
Description of Research Expertise
cf I have been investigating the biochemistry and pharmacology of the cyclooxygenase (COX) pathway and its role in inflammation and cardiovascular disease since I was an undergraduate student.9f I have contributed to understand the human pharmacology of non-steroidal anti-inflammatory drugs (NSAID)s and how they harm the cardiovascular system.
ee My current research focuses on defining the role and regulation of eicosanoids and other bioactive lipids in cardiovascular disease, aging, the response to checkpoint blockade in cancer, and viral infections, such as in COVID-19.
b1 I am also investigating the mechanisms underlying NSAID-induced enteropathy and the time-dependent effect of low-dose aspirin on platelet reactivity and blood pressure.
a8 For my research I integrate studies in model systems using multi-omic (lipidomics, single-cell transcriptomics, metagenomics) and immune profiling approaches.
1f Cyclooxygenase biology.
19 Vascular biology.
3d Pharmacology of nonsteroidal anti-inflammatory drugs.
1c System pharmacology.
10 Genomic.
15 Metabolomics.
13 Microbiome.
17 Rna-Sequencing.
18 Atherosclerosis.
16 Heart Failure.
1e Myocardial infarction.
13 Thrombosis.
1d Platelet Aggregation.
21 NSAID-induced enteropathy.
26 7 1d 1f