Description of Research Expertise

I have been investigating the biochemistry and pharmacology of the cyclooxygenase (COX) pathway and its role in inflammation and cardiovascular disease since I was an undergraduate student.
I have contributed to understand the human pharmacology of non-steroidal anti-inflammatory drugs (NSAID)s and how they harm the cardiovascular system.
My current research focuses on defining the role and regulation of eicosanoids and other bioactive lipids in cardiovascular disease, aging, the response to checkpoint blockade in cancer, and viral infections, such as in COVID-19.
I am also investigating the mechanisms underlying NSAID-induced enteropathy and the time-dependent effect of low-dose aspirin on platelet reactivity and blood pressure.
For my research I integrate studies in model systems using multi-omic (lipidomics, single-cell transcriptomics, metagenomics) and immune profiling approaches.
Cyclooxygenase biology.
Vascular biology.
Pharmacology of nonsteroidal anti-inflammatory drugs.
System pharmacology.
Genomic.
Metabolomics.
Microbiome.
Rna-Sequencing.
Atherosclerosis.
Heart Failure.
Myocardial infarction.
Thrombosis.
Platelet Aggregation.
NSAID-induced enteropathy.