Kristopher R. Bosse, MD
Assistant Professor of Pediatrics (Oncology)
Attending Physician, Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine
Member, Abramson Cancer Center, University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104
Office: 651-492-6726
Fax: 267-426-0685
Fax: 267-426-0685
Email:
bossek@chop.edu
bossek@chop.edu
Education:
BA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
University of Pennsylvania School of Medicine, 2010.
Permanent linkBA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
University of Pennsylvania School of Medicine, 2010.
Selected Publications
Turn, C, Wolpaw A, Bosse KR: Neuroblastoma. Ferri’s Clinical Advisor In press 2025.Shraim R, Schuerch PM, Giudice AM, Conkrite KL, Weiner AK, Radaoui AB, Mooney B, Kurmasheva RT, Houghton PJ, Morin GB, Mosse YP, Sorensen PH, Garcia BA, Sacan A, Maris JM, Bosse KR, Diskin SJ. : GPC2-directed CAR T cells are efficacious against fusion-positive and fusion-negative rhabdomyosarcomas. Presented at the AACR Annual Meeting April 2024.
Strijker JGM*, Pascual-Pasto G*, Kalmeijer YJ, Kalaitsidou E, Zhao C, McIntyre B, Matlaga S, Visser LL, Barisa M, Himsworth C, Shah R, Muller H, Schild LG, Hains PG, Zhong Q, Reddel R, Robinson PJ, Catena X, Soengas MS, Margaritis T, Dekker FJ, Anderson J, Molenaar JJ, Bosse KR*, Wu W*, Wienke J*. *these authors contributed equally. : Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma. BioRxiv April 2024 Notes: doi: https://doi.org/10.1101/2024.04.05.588098 *these authors contributed equally.
Spear TT, Posthill E, Groff D, Giudice AM, Bosse KR, Ma L, Schoenberger AP, Maris JM.: Next-generation immunocompetent and humanized neuroblastoma murine models for the discovery and validation of novel immunotherapies. Presented at the AACR Annual Meeting April 2024.
Giudice AM, Matlaga S, Pascual-Pasto G, Rouin G, McIntyre B, Schuerch P, Bosse KR.: Neuroblastoma extracellular vesicles expose GPC2 and activate GPC2 CAR T cells in an antigen-dependent manner. Presented at the AACR Annual Meeting April 2024.
Randall MP, Egolf LE, Vaksman Z, Samanta M, Tsang M, Groff D, Evans JP, Rokita JL, Layeghifard M, Shlien A, Maris JM, Diskin SJ, Bosse KR. : BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma. Journal of the National Cancer Institute 1: 138-148, January 2024.
Kim J, Vaksman Z, Egolf LE, Kaufman R, Evans JP, Conkrite KL, Danesh A, Lopez G, Randall MP, Dent MH, Farra LM, Menghani N, Dymek M, Desai H, Hausler R, Penn Medicine BioBank, Regeneron Genetics Center, Cancer Genomics Research Laboratory, Auvil JG, Gerhard DS, Hakonarson H, Maxwell KN, Cole KA, Pugh TJ, Bosse KR, Khan J, Wei JS, Maris JM, Stewart DR, Diskin SJ.: Germline pathogenic variants in 786 neuroblastoma patients. Journal of the National Cancer Institute 1: 149-159, January 2024.
Pascual-Pasto G, McIntyre B, Giudice AM, Alikarami F, Morrissey A, Matlaga S, Hofmann TJ, Burgueño V, Harvey K,cMartinez D, Shah AC, Foster JB, Pogoriler J, Eagle RC, Carcaboso AM, Shields CL, Leahey AM, Bosse KR. : Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T-cells. Clinical Cancer Research In press 2024 Notes: In press.
Wolpaw A, Bosse KR. : Neuroblastoma. Ferri’s Clinical Advisor 2024.
Weiner AK, Radaoui AB, Tsang M, Martinez D, Sidoli S, Conkrite KL, Delaidelli A, Modi A, Rokita JL, Patel K, Lane MV, Zhang B, Zhong C, Ennis B, Miller DP, Brown MA, Rathi KS, Raman P, Pogoriler J, Bhatti T, Pawel B, Glisovic-Aplenc T, Teicher B, Erickson SW, Earley EJ, Bosse KR, Sorensen PH, Krytska K, Mosse YP, Havenith KE, Zammarchi F, van Berkel PH, Smith MA, Garcia BA, Maris JM, Diskin SJ.: A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma. BioRxiv December 2023 Notes: doi: 10.1101/2023.12.06.570390.