Kristopher R. Bosse, MD

faculty photo
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104
Office: 651-492-6726
Fax: 267-426-0685
Education:
BA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
University of Pennsylvania Perelman School of Medicine, 2010.
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Selected Publications

Buongervino S, Lane M, Martinez D, Zhelev DV, Maris J, Dimitrov DS, Bosse KR : Elucidation of the mechanisms of cytotoxicity of the GPC2-targeting antibody-drug conjugate D3-GPC2-PBD in high-risk neuroblastoma. Presented at the Children’s Hospital of Philadelphia Research Poster Day, Philadelphia, PA USA May 2019 Notes: poster.

Foster J, Griffin C, Stern A, Brimley C, Lane M, Buongervino S, Dimitrov DS, Barrett D, Resnick A, Maris J, Bosse K : Development of GPC2-directed chimeric antigen receptor therapy for pediatric brain tumors with in vitro transcribed mRNA Presented at the Society for Neuro-Oncology (SNO) Annual Meeting, San Francisco, CA USA May 2019 Notes: poster.

Bosse KR, Hunger SP: Molecular and Cellular Biology of Cancer. Nelson Textbook of Pediatrics 21st Edition April 2019.

Bosse KR, Buongervino S, Lane M, Hyman A, Gemino-Borromeo M, Saggio S, Fitzsimmons A, Forcier B, Murphy A, Cooke M, Wick J, Webster J, Madison R, Welsh A, Miller VA, Ali SM, Maris J, Mosse Y: Serial Profiling of ctDNA reveals clinically actionable genomic evolution in high-rise neuroblastoma. Presented at the American Association for Cancer Research Annual Meeting, Atlanta, GA USA April 2019 Notes: poster.

Bosse KR, Lane M, Buongervino S, Metzger S, Martinez D, Zhelev DV, Feng Y, Wang Y, Hwang J, Mackall C, Dimitrov D, Maris JM: The antibody-drug conjugate D3-GPC2-PBD potently eradicates neuroblastoma patient-derived xenografts Presented at the ASCI’s Food & Science Evening at the AAP/ASCI/APSA Joint Meeting, Chicago, IL USA April 2019 Notes: poster.

Bosse KR : From common to rare variation in cancer predisposition: BARD1 in neuroblastoma as an example Presented at the Forbeck Focus Meeting: Cancer Predisposition, Lake Geneva, WI USA November 2018.

Randall M, Bosse KR, Vaksman Z, Evans P, Diskin SJ, Maris JM: Neuroblastoma-associated BARD1 germline mutations are associated with somatic defects in DNA double-strand break (DSB) repair. Presented at the Advances in Neuroblastoma Research Congress, San Francisco, CA USA May 2018 Notes: poster.

Bosse KR, Zhu Z, Lane M, Martinez D, Zhelev DV, Feng Y, Wang Y, Hwang J, Mackall C, Dimitrov D, Maris J: The antibody-drug conjugate D3-GPC2-PBD potently eradicates neuroblastoma patient-derived xenografts. Presented at the Advances in Neuroblastoma Research Congress, San Francisco, CA USA May 2018 Notes: oral/podium.

Bosse KR, Lane M, Hyman A, Gemino-Borromeo M, Saggio S, Fitzsimmons A, Guerra A, Forcier B, Cooke C, Webster J, Welsh A, Miller VA, Ali SM, Maris J, Mosse Y: Serial profiling of neuroblastoma ctDNA reveals potentially actionable tumor genetic heterogeneity and evolution. Presented at the Advances in Neuroblastoma Research Congress, San Francisco, CA USA May 2018 Notes: oral/podium.

Ritenour L, Randall M, Bosse KR, Diskin, S. : Genetic predisposition to neuroblastoma: current knowledge and future directions. Cell & Tissue Research May 2018.

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Last updated: 05/22/2019
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