Kristopher R. Bosse, MD
Assistant Professor of Pediatrics (Oncology)
Attending Physician, Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania
Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104
3501 Civic Center Boulevard, CTRB 3050
Philadelphia, PA 19104
Office: 651-492-6726
Fax: 267-426-0685
Fax: 267-426-0685
Email:
bossek@chop.edu
bossek@chop.edu
Education:
BA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania , 2010.
Permanent linkBA (Biochemistry )
Bowdoin College, 2002.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania , 2010.
Selected Publications
Guerra AD, Matkar S, Acholla C, Casey C, Li G, Mazzeschi M, Patel K, Krytska K, Chen C, Balyasny S, Kalna J, Kamitsuka P, Gerelus M, Polkosnik1 G, Groff D, Mukherje A, Adams A, Witek G, Hamilton AK, Martinez D, Pogoriler J, Spear TT, Li Y, Jung P, Alvarado D, Lauriola M, Maris JM, Wolpaw AJ, Bosse KR, Dimitrov D, Mir M, Jelev DV, Mossé YP: A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate CDX0239-PBD demonstrates potent efficacy in ALK-expressing cancers. Nature Communications August 2025, in press.Bosse KR, Wray L, Varghese M, Giudice A, Roth S, Matlaga S, Gladney W, Nguyen Mau S-M, Vultur A, McIntyre B, Martinez D, Sparrow A, Dinofia A, Gallagher D, Pogoriler J, Kreiger P, Takeda M, Barrett D, Davis JC, States LJ, Mosse Y, Gonzales V, Fraietta JA, Grupp S, Maris JM: Safety and efficacy in a first-in-human GPC2 CAR T cell phase 1 trial for neuroblastoma. Plenary talk presented at the Advances in Neuroblastoma Research Congress May 2025.
Giudice AM, Roth S, Matlaga S, Cresswell-clay E, Mishra P, Schürch PM, Samanta M, Pascual-Pasto G, Spear TT, McIntyre B, Chada N, Wang T, Liu L, Wang R, Wilson JT, Wolpaw AJ, Bosse KR: Reprogramming the neuroblastoma tumor immune microenvironment to enhance GPC2 CAR T cells. Molecular Therapy May 2025.
Pan H, Nelson B, Joshi N, Harvey K, Pascual-Pasto G, Schuerch PM, Zecchino VP, Madsen PJ, Bosse KR, Foster JB: Locoregional delivery of GPC2 CAR T cells is safe and effective in preclinical models of pediatric central nervous system tumors. Presented at the SNO Pediatric Neuro-Oncology Research Conference May 2025.
Spear TT, Samata M, Pastor S, Patel K, Farrel A, Posthill E, Groff D, Giudice AM, Bosse KR, Wang T, Liu L, Wang R, Maris JM: A tractable immune competent neuroblastoma murine model for immunoncology (IO) preclinical studies. Presented at the Advances in Neuroblastoma Research Congress May 2025.
Narch A, Shapiro M, Mishra P, Jung P, Bayingana K, Dessau JL, Dong MM, Patel A, Bosse KR, Dang CV, Wolpaw AJ: Targeting lineage heterogeneity in neuroblastoma via cGAS-STING. Parallel talk presented at the Advances in Neuroblastoma Research Congress May 2025.
Giudice AM, Roth S, Matlaga A, Cresswell-clay E, Schürch PM, Samanta M, Pascual-Pasto G, Spear T, McIntyre B, Mishra P, Chada N, Wang R, Wilson JT, Wolpaw AJ, Bosse KR: Reprogramming the immunosuppressive tumor microenvironment by armoring GPC2 CAR T cells with CXCR2. Presented at the Advances in Neuroblastoma Research Congress May 2025.
Shapiro M, Narch A, Mishra P, Jung P, Bayingana K, Bosse KR, Wolpaw AJ: A CRISPR-Cas9 screen uncovers lineage state-specific regulation of inflammatory signaling. Presented at the Advances in Neuroblastoma Research Congress May 2025.
Schürch PM, Zecchino VP, Giudice AM, Mcintyre BC, Roth S, Kaufman R, Shraim R, Hamilton AK, Pascual-Pasto G, Mishra P, Groff D, Martinez D, Li W, Diskin SJ, Bosse K: The super-enhancer driven nicotinic acetylcholine α3β4 receptor complex as an immunotherapeutic target in high-risk neuroblastoma. Plenary talk presented at the Advances in Neuroblastoma Research Congress May 2025.
Strijker JGM*, Pascual-Pasto G*, Grothusen GP, Kalmeijer YJ, Kalaitsidou E, Zhao C, McIntyre B, Matlaga S, Visser LL, Barisa M, Himsworth C, Shah R, Muller H, Schild LG, Hains PG, Zhong Q, Reddel R, Robinson PJ, Catena X, Soengas MS, Margaritis T, Dekker FJ, Anderson J, Molenaar JJ, Bosse KR*, Wu W*, Wienke J*. *, these authors contributed equally: Blocking MIF secretion enhances CAR T cell efficacy against neuroblastoma. European Journal of Cancer January 2025.