Stephan Kadauke, M.D., Ph.D.
Associate Professor of Clinical Pathology and Laboratory Medicine
Attending Physician, Division of Transfusion Medicine, Children's Hospital of Philadelphia
Faculty Member, Division of Pathology Informatics, Children's Hospital of Philadelphia
Faculty Member, Department of Biomedical Health Informatics
Medical Director, Cell and Gene Therapy Informatics, Children's Hospital of Philadelphia
Associate Director, Cell Based Therapy Laboratory, Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Contact information
Children's Hospital of Philadelphia
CTRB, Fourth Floor, Room 4022
3501 Civic Center Blvd
Philadelphia, PA 19104
CTRB, Fourth Floor, Room 4022
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-616-9737
Publications
Links
Search PubMed for articles
CHOP Cell and Gene Therapy Informatics Blog
Stephan Kadauke's LinkedIn
CHOP Cell and Gene Therapy Laboratory
Search PubMed for articles
CHOP Cell and Gene Therapy Informatics Blog
Stephan Kadauke's LinkedIn
CHOP Cell and Gene Therapy Laboratory
Education:
BA (Biochemistry, summa cum laude)
Columbia University, 2005.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2012.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2014.
Permanent linkBA (Biochemistry, summa cum laude)
Columbia University, 2005.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2012.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2014.
Description of Clinical Expertise
Cellular therapy, cGMP, stem cells, bone marrow transplant, chimeric antigen receptor, CAR-T cells, virus-specific cytotoxic T lymphocytes, T/B cell depletion, cell manufacturing, graft manipulation, CliniMACS Prodigy, transfusion medicine, apheresis, red blood cell exchange, plasma exchange, thalassemia, sickle cell disease, thrombosis and hemostasis, coagulation, utilization management, laboratory information systems, healthcare analytics, clinical informatics, pathology informatics, datamart, enterprise data warehouseDescription of Research Expertise
Reproducible research, tidyverse, R, RStudio, R Markdown, Quarto, clinical data science, machine learning, tidymodels, GitHub, gene therapy, erythropoiesis, epigenetics, chromatin, CAR-T cells, immunotherapy, virus-specific cytotoxic T lymphocytes, GMP manufacturingSelected Publications
Burke R, Devassy R, Kadauke S: Collaborating for Success: A Nurse and Systems Analyst Perspective on Implementing the Epic Cell Therapy Module at CHOP. Cellicon Valley Conference May 2025 Notes: Oral presentation at Cellicon Valley.Gibson N, Al Riyami A, Peedin A, Kadauke S, Grupp S, Olson T, Wang Y: Challenging immunophenotyping of sickle cell patients adversely affects gene therapy product manufacturing – case reports. Cytotherapy May 2025 Notes: Platform presentation at ISCT 2025, New Orleans, LA.
Cotteta S, Banda O, Wang Y, Alameh MG, Khandros E, Kadauke S: Preclinical development of a cost-efficient sickle cell disease base editor gene therapy via lipid nanoparticle delivery. CHOP Research Day May 2025.
Devassy R, Peters AJ, Porter E, Hanna RS, Atkinson M, Vernau L, Machietto R, Giacobbe NJ, Wilson BE Jr, Phillips CA, Blythe A, Phillips J, Potter J, Gray K, Molitoris K, Precourt M, Collier V, Hankins P, Grupp SA, Olson TS, Kadauke S: Implementing the Epic Cell Therapy Module: Lessons from a Comprehensive Digital Transformation. Transplantation and Cellular Therapy 31(2): S91, February 2025 Notes: Platform presentation at ASTCT 2025, Honolulu, HI.
Porter E, Grupp SA, Hanna R, Olson TS, Phillips C, Kadauke S: Predictive Modeling for Bone Marrow Transplant Inpatient Census: A 15- to 60-Day Forecasting Approach. Transplantation and Cellular Therapy 31(2): S526-S527, February 2025 Notes: Poster presentation at ASTCT 2025, Honolulu, HI.
Frangoul H, Wang Y, McManus M, Kadauke S, Grupp SA, Evans M: Unmet Need in Stem Cell Mobilization for Gene Therapy in Patients with Sickle Cell Disease (SCD): A Multicenter Review. Transplantation and Cellular Therapy 31(2): S255, February 2025 Notes: Poster presentation at ASTCT 2025.
Burke R, Atkinson M, Choudhari SS, Collier V, Giacobbe N, Gonnella K, Gray K, Kadauke S, Machietto R, Molitoris K, Olson TS, Phillips J, Potter J, Roth E, Smith K: Cellular Therapy Infusion Flowsheets: Epic Integration. Transplantation and Cellular Therapy 31(2): S462-S463, February 2025 Notes: Poster presentation at ASTCT 2025 in Honolulu, HI.
Lescoat A, Ghosh M, Kadauke S, Khanna D: Innovative cell therapies for systemic sclerosis: available evidence and new perspectives. Expert Review of Clinical Immunology 21(1): 29-43, January 2025.
Grzywa T, Mehta N, Cossette B, Romanov A, Paruzzo L, Ramasubramanian R, Cozzone A, Morgan D, Sukaj I, Bergaggio E, Tannir R, Kadauke S, Myers R, Yousefpour P, Ghilardi G, Schuster S, Neeser A, Frey M, Goncalves B, Zhang L, Abraham W, Suh H, Ruella M, Grupp SA, Chiarle R, Wittrup KD, Ma L, Irvine DJ : Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells. bioRxiv (Preprint) October 2024.
Wyatt KD, Alexander N, Hills GD, Liang WH, Kadauke S, Volchenboum SL, Mian A, Phillips CA: Making sense of artificial intelligence and large language models—including ChatGPT—in pediatric hematology/oncology. Pediatric Blood & Cancer 71(9): e31143, September 2024.