Stephan Kadauke, M.D., Ph.D.
Associate Professor of Clinical Pathology and Laboratory Medicine
Attending Physician, Division of Transfusion Medicine, Children's Hospital of Philadelphia
Faculty Member, Division of Pathology Informatics, Children's Hospital of Philadelphia
Faculty Member, Department of Biomedical Health Informatics
Medical Director, Cell and Gene Therapy Informatics, Children's Hospital of Philadelphia
Associate Director, Cell Based Therapy Laboratory, Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Contact information
Children's Hospital of Philadelphia
CTRB, Fourth Floor, Room 4022
3501 Civic Center Blvd
Philadelphia, PA 19104
CTRB, Fourth Floor, Room 4022
3501 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-616-9737
Publications
Links
Search PubMed for articles
Stephan Kadauke's LinkedIn
CHOP Cell and Gene Therapy Laboratory
CHOP Cell and Gene Therapy Informatics Blog
Search PubMed for articles
Stephan Kadauke's LinkedIn
CHOP Cell and Gene Therapy Laboratory
CHOP Cell and Gene Therapy Informatics Blog
Education:
BA (Biochemistry, summa cum laude)
Columbia University, 2005.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2012.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2014.
Permanent linkBA (Biochemistry, summa cum laude)
Columbia University, 2005.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2012.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2014.
Description of Clinical Expertise
Cellular therapy, cGMP, stem cells, bone marrow transplant, chimeric antigen receptor, CAR-T cells, virus-specific cytotoxic T lymphocytes, T/B cell depletion, cell manufacturing, graft manipulation, CliniMACS Prodigy, transfusion medicine, apheresis, red blood cell exchange, plasma exchange, thalassemia, sickle cell disease, thrombosis and hemostasis, coagulation, utilization management, laboratory information systems, healthcare analytics, clinical informatics, pathology informatics, datamart, enterprise data warehouseDescription of Research Expertise
Reproducible research, tidyverse, R, RStudio, R Markdown, Quarto, clinical data science, machine learning, tidymodels, GitHub, gene therapy, erythropoiesis, epigenetics, chromatin, CAR-T cells, immunotherapy, virus-specific cytotoxic T lymphocytes, GMP manufacturingSelected Publications
Porter E, Hanna RS, Grupp SA, Kadauke S: Operational and Data Quality Alerting in a Cell Therapy Laboratory. Transplantation and Cellular Therapy 32(2): S566, February 2026 Notes: Poster presentation at ASTCT 2026.Porter E, Hanna RS, Olson TS, Grupp SA, Phillips CA, Kadauke S: Multi-Week Forecasting of Pediatric BMT Census: Deployment and Operationalization. Transplantation and Cellular Therapy 32(2): S565, February 2026 Notes: Poster at ASTCT 2026.
Elgarten CW, Oved JH, Wray L, Venella K, Nicholas P, Kadauke S, Wang Y, Grupp S, Olson TS: Alternative Donor Peripheral Stem Cell Transplantation With TCRαβ/CD19 Depletion for Pediatric Patients With Bone Marrow Failure. EJC Paediatric Oncology 6(Supplement 1), December 2025.
Cotteta S, Banda O, Herbst-Nowrouzi F, McDonald B, Wang Y, Alameh MG, Bushman F, Grupp SA, Khandros E, Kadauke S: Toward ‘n of one’ gene therapies: Scalable ex vivo adenine base editing via lipid nanoparticles in a sickle cell disease model. Blood 146(Supp 1): 7835, November 2025.
Grzywa T, Mehta N, Cossette B, Romanov A, Paruzzo L, Ramasubramanian R, Cozzone A, Morgan D, Sukaj I, Bergaggio E, Tannir R, Kadauke S, Myers R, Yousefpour P, Ghilardi G, Schuster S, Neeser A, Frey M, Goncalves B, Zhang L, Abraham W, Suh H, Ruella M, Grupp SA, Chiarle R, Wittrup KD, Ma L, Irvine DJ : Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells. Nature Biomedical Engineering August 2025.
Gibson NM, Elgarten CW, Oved JH, Wray L, Freedman J, Khandros E, Worster E, Nicholas P, Kadauke S, Wang Y, Grupp S, Kwiatkowski JL, Olson TS: Outcomes of Unrelated Donor Stem Cell Transplantation with Partial T Cell Depletion for Pediatric Patients with Hemoglobinopathies. Transplantation and Cellular Therapy 31(10): 828.e1-8282.e14, July 2025.
Burke R, Devassy R, Kadauke S: Collaborating for Success: A Nurse and Systems Analyst Perspective on Implementing the Epic Cell Therapy Module at CHOP. Cellicon Valley Conference May 2025 Notes: Oral presentation at Cellicon Valley.
Gibson N, Al-Riyami AZ, Peedin A, Kadauke S, Grupp SA, Olson T, Wang Y: Challenging immunophenotyping of patients with sickle cell disease adversely affects gene therapy product manufacturing – case reports. Cytotherapy 27(5): S39, May 2025 Notes: Platform presentation at ISCT 2025, New Orleans, LA.
Cotteta S, Banda O, Wang Y, Alameh MG, Khandros E, Kadauke S: Preclinical development of a cost-efficient sickle cell disease base editor gene therapy via lipid nanoparticle delivery. CHOP Research Day May 2025.
Devassy R, Peters AJ, Porter E, Hanna RS, Atkinson M, Vernau L, Machietto R, Giacobbe NJ, Wilson BE Jr, Phillips CA, Blythe A, Phillips J, Potter J, Gray K, Molitoris K, Precourt M, Collier V, Hankins P, Grupp SA, Olson TS, Kadauke S: Implementing the Epic Cell Therapy Module: Lessons from a Comprehensive Digital Transformation. Transplantation and Cellular Therapy 31(2): S91, February 2025 Notes: Platform presentation at ASTCT 2025, Honolulu, HI.